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排序方式: 共有1067条查询结果,搜索用时 31 毫秒
991.
992.
993.
Ali H. Abu Almaaty Nermeen A. Elgrahy Eman Fayad Ola A. Abu Ali Ahmed R. E. Mahdy Lamiaa A. A. Barakat Mohammed El Behery 《Molecules (Basel, Switzerland)》2021,26(16)
A new series of hybrid molecules containing cinnamic acid and 2-quinolinone derivatives were designed and synthesized. Their structures were confirmed by 1H-NMR, 13C-NMR and mass analyses. All the synthesized hybrid molecules were assessed for their in vitro antiproliferative activity against more than one cancer cell lines. Compound 3-(3,5-dibromo-7,8-dihydroxy-4-methyl-2-oxoquinolin-1(2H)-ylamino)-3-phenylacrylic acid (5a) with IC50 = 1.89 μM against HCT-116 was proved to the most potent compound in this study, as compared to standard drug staurosporin. DNA flow cytometry assay of compound 5a revealed G2/M phase arrest and pre-G1 apoptosis. Annexin V-FITC showed that the percentage of early and late apoptosis was increased. The results of topoisomerase enzyme inhibition activity showed that the hybrid molecule 5a displays potent inhibitory activity compared with control. 相似文献
994.
Abu Bakr El‐Bediwi 《Crystal Research and Technology》2005,40(7):688-691
Using x‐ray diffractometry, double bridge method and dynamic resonance technique structure, electrical resistivity, elastic modulus, internal friction and thermal diffusivity of Pb63‐xSn30Sb7Cux [x=0 or x≤2.5] quaternary melt spun alloys have been investigated. Adding Cu to PbSn30Sb7 decreases electrical resistivity, elastic modulus and internal friction. The PbSn30Sb7Cu1 melt spun alloy has better properties as bearing alloy, such as low electrical resistivity, high elastic modulus and adequate internal friction, compared with the Pb88Sn10Cu2 alloy used for automotive applications (FIAT Normalizzazione). That means, it has good properties as lead free (non‐toxic) bearing alloy. (© 2005 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
995.
Somayeh Soleimani‐Amiri Zinatossadat Hossaini Maryam Arabkhazaeli Hossein Karami Saeid Afshari Sharif Abad 《中国化学会会志》2019,66(4):438-445
In this paper, we report the synthesis of pyrimido[2,1‐a] isoquinoline and pyrimido[1,2‐a]quinoline derivatives in high yields from the reaction of isoquinoline or quinoline, activated acetylenic compounds, and amides in the presence of ZnO nanorods (ZnO‐NRs) as catalyst under solvent‐free conditions at room temperature. ZnO‐NRs show good improvement in the yield of the product and significant reusability. Also, the antioxidant activities of the some of the newly synthesized compounds were carried out by 1,1‐diphenyl‐2‐picrylhydrazyl (PDDH) radical trapping and ferric ion reducing potential tests and compared with those of the synthetic antioxidants 2‐tert‐butylhydroquinone (TBHQ) and butylated hydroxytoluene (BHT). These compounds do not show good DPPH radical scavenging but display good ferric ion reducing power. 相似文献
996.
Islam H. El Azab Ola A. Abu Ali Aishah H. El‐Zahrani Adil A. Gobouri Tariq A. Altalhi 《Journal of heterocyclic chemistry》2019,56(1):18-31
Herein, we reported the efficient synthesis of new azoles as bio‐functional analogs, employing the easily obtainable N‐acetyl‐3,5‐diphenyl‐4,5‐dihydro‐1H‐pyrazole‐1‐carbothioamide ( 1 ), as a versatile precursor. The structures of the newly synthesized compounds were elucidated based on their IR, 1H NMR, and 13C NMR mass spectral and elemental analysis. Furthermore, some selected compounds were evaluated in vitro for their antimicrobial activities. The preliminary bioassay results indicate that the majority of the tested compounds exhibited significant antimicrobial activity. Compounds 12 , 11 , 18 , 30 , 22 , 3 , and 2 were found to be the most potent against the tested microorganisms with minimum inhibitory concentration ≤ (12.25 μg/mL), indicating that conjugates bearing thiazole moiety, as well as those with N‐substituted electron‐withdrawing groups, exhibited higher potency than the rest of other compounds. 相似文献
997.
Yasmeen M. Ali Mahmoud F. Ismail Fatma S. M. Abu El‐Azm Magda I. Marzouk 《Journal of heterocyclic chemistry》2019,56(9):2580-2591
In an endeavor to develop antitumor agents, we made a credible survey regarding synthesis, structure, and pharmacological assay of novel pyridazine derivatives, so that 2‐((6‐(4‐chloro‐3‐methylphenyl)pyridazin‐3‐yl)oxy)acetohydrazide 3 was utilized as scaffold to build novel compounds 4 – 19 by reaction with various electrophilic reagents, followed by determination and explanation atropisomerism phenomena and tauomerism ratio such as keto‐enol and lactam–lactim tautomers for some synthesized compounds. In vitro, these compounds were screened for antitumor efficacy versus two cell lines, namely, hepatocellular carcinoma and mammary gland breast cancer, by using MTT assay. Among the examined compounds, compound 16 was exhibited promising potent activity (IC50 = 8.67 ± 0.7 μM) versus HepG2 cell line. Meanwhile, compounds 3 and 16 were manifested the very highest efficacy (IC50 = 5.68 ± 0.6 and 9.41 ± 0.9 μM) versus MCF‐7 cell line. 相似文献
998.
Sharif M. Z. Azmi W. H. Redhwan A. A. M. Mamat R. Najafi G. 《Journal of Thermal Analysis and Calorimetry》2019,135(2):1285-1297
Journal of Thermal Analysis and Calorimetry - The use of automotive air conditioning (AAC) nowadays is essential because of the hot climate and global warming. The AAC increases the overall fuel... 相似文献
999.
Earth-abundant transition metal-based catalysts have been extensively investigated for their applicability in water electrolysers to enable overall water splitting to produce clean hydrogen and oxygen. In this study a Fe−Co based catalyst is electrodeposited in 30 seconds under vigorous hydrogen evolution conditions to produce a high surface area material that is active for both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER). This catalyst can achieve high current densities of 600 mAcm−2 at an applied potential of 1.6 V (vs RHE) in 1 M NaOH with a Tafel slope value of 48 mV dec−1 for the OER. In addition, the HER can be facilitated at current densities as high as 400 mA cm−2 due to the large surface area of the material. The materials were found to be predominantly amorphous but did contain crystalline regions of CoFe2O4 which became more evident after the OER indicating interesting compositional and structural changes that occur to the catalyst after an electrocatalytic reaction. This rapid method of creating a bimetallic oxide electrode for both the HER and OER could possibly be adopted to other bimetallic oxide systems suitable for electrochemical water splitting. 相似文献
1000.
Md. Sharif Hossain Shota Inoue Mohammad Shahabuddin Takao Kimura Michinori Karikomi 《Tetrahedron letters》2019,60(25):1682-1685
The thermal rearrangement reaction of helical-shaped quinone (benzofused-2,2′-diphenoquinone derivative) afforded three types of poly-condensed oxygen-containing heterocyclic compounds. One type of them was spiro compound which is consisting of cyclopentadiene and γ-butyrolactone. The other two compounds were helically condensed compounds, one of them containing as cyclopentadiene and pyranone ring and the other consists of fused furan and oxepin ring. These products were could be selectively synthesized by the choosing modification of reaction conditions. Moreover, the mechanistic aspects of these reactions are also discussed. 相似文献