Hyaluronan: from biomimetic to industrial business strategy

Hyaluronan (hyaluronic acid) is a naturally occurring polysaccharide of a linear repeating disaccharide unit consisting of beta-(1-->4)-linked D-glucopyranuronic acid and beta-(1-->3)-linked 2-acetamido-2-deoxy-D-glucopyranose, which is present in extracellular matrices, the synovial fluid of joints, and scaffolding that comprises cartilage. In its mechanism of synthesis, its size, and its physico-chemical properties, hyaluronan is unique amongst other glycosaminoglycans. The network-forming, viscoelastic and its charge characteristics are important to many biochemical properties of living tissues. It is an important pericellular and cell surface constituent; its interaction with other macromolecules such as proteins, participates in regulating cell behavior during numerous morphogenic, restorative, and pathological processes in the body. The knowledge of HA in diseases such as various forms of cancers, arthritis and osteoporosis has led to new impetus in research and development in the preparation of biomaterials for surgical implants and drug conjugates for targeted delivery. A concise and focused review on hyaluronan is timely. This review will cover the following important aspects of hyaluronan: (i) biological functions and synthesis in nature; (ii) current industrial production and potential biosynthetic processes of hyaluronan; (iii) chemical modifications of hyaluronan leading to products of commercial significance; and (iv) and the global market position and manufacturers of hyaluronan.     

Mixed mode axisymmetric annular cracks in a finite layer: Off angle crack initiation

The solutions of axisymmetric Volterra type climb and glide edge dislocations are obtained in a layer by means of the Hankel transforms. Utilizing the same procedure, Green’s function solution is obtained for a layer under self-equilibration normal ring traction. The distributed dislocation technique is used to construct integral equations for a system of co-axial annular cracks where the layer is under axisymmetric normal loads. These equations are solved numerically to obtain dislocation density on the cracks surfaces. The results are employed to determine stress intensity factors for annular and penny-shaped cracks and the interaction between two co-axial penny-shaped cracks is studied. Moreover, the stress intensity factors of the interacting cracks are determined such that they can be further used in conjunction with strain energy density (SED) failure criterion to obtain the possible direction of crack initiation that may not be apparent under mixed mode conditions.     

Investigation of three dimensional air flow characteristic and effect of heated obstruction within room

This study reports the results of a numerical investigation of three-dimensional turbulent buoyant recirculating flow within rooms with heated obstruction. The study involves the solution of partial differential equations for the conservation of mass, momentum, energy, concentration, turbulent energy and its dissipation rate. These equations were solved together with algebraic expressions for the turbulent viscosity and heat diffusivity using k-ε turbulence model by performing simulations on FLUENT 6.3. The CFD method was validated via comparing with the available experimental data. A comparison with experimental results shows good agreement. This means that the present computer code has a good capability to simulate 3D airflow and effect of obstruction within room. The present study demonstrates the flow behavior, thermal distribution and CO₂ concentration inside the room in the presence of heat flux obstruction. Two different configurations of ventilation system have been studied. Mixing and Displacement ventilation system have been used in two geometries depending on location of opening inlet. The ventilation effectiveness for heat removal (E_T) is used to evaluate the indoor climate and average temperature is an important parameter in designs the ventilation systems. Two notable points are presented; first, mixing ventilation is depending on throw of jet. CO₂ concentration and temperature distribution have been effected in upper zone more than occupied zone with presence the obstruction. Second notable points are presented; in displacement ventilation buoyancy effect is considerable. Vertical temperature gradient above the obstruction implies that both fresh air and CO₂ concentration.     

Expectation identities of lower generalized order statistics from generalized exponential distribution and a characterization

In this paper, we study the explicit expressions and some recurrence relations for single and product moments of lower generalized order statistics from generalized exponential distribution. The results include as particular cases the above relations for moments of order statistics and lower records. Further, using a recurrence relation for single moments we obtain a characterization of generalized exponential distribution.     

Proximal-type algorithms for split minimization problem in P-uniformly convex metric spaces

Numerical Algorithms - In this paper, we study strong convergence of some proximal-type algorithms to a solution of split minimization problem in complete p-uniformly convex metric spaces. We also...     

Tensile Properties of Graphene-Based Nanocomposites: a Comparative Study of Ultrasonication and Microcompounding Processing Methods

Mechanics of Composite Materials - Two methods are commonly used to disperse graphene nanoplatelets (GNPs) in a polymer matrix system (PMS) — microcompounding and ultrasonication. In this...     

On contact graphs of totally separable domains

Aequationes mathematicae - Contact graphs have emerged as an important tool in the study of translative packings of convex bodies. The contact number of a packing of translates of a convex body is...     

Minimal-speed selection of traveling waves to the Lotka–Volterra competition model

In this paper the minimal-speed determinacy of traveling wave fronts of a two-species competition model of diffusive Lotka–Volterra type is investigated. First, a cooperative system is obtained from the classical Lotka–Volterra competition model. Then, we apply the upper-lower solution technique on the cooperative system to study the traveling waves as well as its minimal-speed selection mechanisms: linear or nonlinear. New types of upper and lower solutions are established. Previous results for the linear speed selection are extended, and novel results on both linear and nonlinear selections are derived.     

On virtual pathwidth of virtual graphs of a virtual link

The geometric representation of a knot is not too dissimilar from a graph and this interaction has helped mathematicians to solve many problems. In this paper, we apply graph theory tools to study the classification of virtual knots and links. We define virtual planar graphs and compute virtual path width of an associated graph of a virtual link. We show that the virtual path width of an associated graph is equal to the virtual bridge number of a pseudo prime knot.     

Boundary element method for wave trapping by a multi-layered trapezoidal breakwater near a sloping rigid wall

This study examines the multiple layers in a rubble mound breakwater and their effect on reflection and dissipation of incoming ocean waves. The numerical model is developed using multi-domain boundary element method for oblique water wave trapping near a sloping wall by a multi-layered trapezoidal porous structure, which is utilized to model armour, filter and core layers while examining the hydrodynamics in different configurations. Both, the constant element and linear element approaches to boundary element method are discussed. The cases of bottom-standing porous structures as being submerged and fully extended are considered. The wave hydrodynamics over the structure is described by the reflection and dissipation coefficients along with the forces acting on the sloping wall, and is influenced by wave and structural parametrics of the system. The influence of armour layer in different configurations is highlighted for various structural and wave parameters.