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41.
The dose-dependent lipid accumulation caused by fenitrothion administration is associated with alteration of the ratio of various components of phospholipids and neutral lipids in various organs of rats up to 48 h. The concentration of triacylglycerol, phosphatidyl choline, phosphatidyl ethanolamine and phosphatidyl glycerol increased in liver, kidney and brain in treated rats whereas phosphatidyl serine was greatly reduced. High-performance liquid chromatography and gas-liquid chromatography were used for quantiative analysis of phospholipids and triacylglycerol. The changes in relative composition of various lipids by fenitrothion administration may lead to malfunctioning and alteration of biological properties. 相似文献
42.
We report a detailed theoretical calculation of the electronic band structure of CeO2 in cubic and orthorhombic phases under pressure using a tight-binding linear muffin-tin orbital method (TB-LMTO) within local density approximation (LDA). The compressibility behavior of this compound was discussed in the light of the changes occurring in the electronic structure. Apart from the electronic band structure and structural stability calculations, the density of states (DOS) and Fermi energies (Ef) at various pressures are calculated. The calculated lattice parameter, transition pressure, bulk modulus and the pressure-volume relation are found out to be in good agreement with experimental results. 相似文献
43.
Ganeshpurkar Ankit Singh Ravi Shivhare Shalini Divya Kumar Devendra Gutti Gopichand Singh Ravibhushan Kumar Ashok Singh Sushil Kumar 《Molecular diversity》2022,26(3):1455-1479
Molecular Diversity - Structure-based drug design (SBDD) is an important in silico technique, used for the identification of enzyme inhibitors. Acetylcholinesterase (AChE), obtained from... 相似文献
44.
Souvik Guha Ibrahim Yussif El-Deeb Shalini Yadav Ranajit Das Dr. Kshatresh Dutta Dubey Mousumi Baruah Dr. Ludovic Gremaud Prof. Dr. Subhabrata Sen 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(63):e202202405
Herein we have reported the discovery of a pentacyclic building block comprised of fused indole-quinoline and piperidinone from the natural product perophoramidine as a formidable anticancer agent. The compounds were synthesized in six steps where the key steps involved a blue LED mediated intramolecular cyclopropanation of the indole intermediates and concomitant reduction of the associated aryl nitro moiety to nitroso in the molecule. Cytotoxicity screening of the compounds against an array of cancer cells that is, MCF7, HCT116 and A549 demonstrated 0.6 to 9 μM IC50s by few of the compounds. γH2AX immunofluorescence assay of the two most potent molecules from the phenotypic screening with anti-γ-H2AX Alexa Fluor 488 antibody revealed extensive DNA damage of the A549 cells which indicated probable PARP inhibition (similar to Perophoramidine). Through molecular docking and molecular dynamic (MD) simulation studies the binding efficiency of our compounds with poly(ADP-ribose)polymerase 1 (PARP 1) enzyme was determined. Chemiluminescent PARP Assay with Histone-coated strips indicated that the most active compounds from the phenotypic screening induced PARP-1 inhibition with IC50s of 1.3→1.5 μM. 相似文献
45.
Kumar Rohit Raj Abhishek Kardam Jyoti Kumar Arora Shalini Srivastava 《Journal of Radioanalytical and Nuclear Chemistry》2010,283(3):797-801
The tendency of selenium to interact with heavy metals in presence of naturally occurring species has been exploited for the
development of green bioremediation of toxic metals from soil using Artificial Neural Network (ANN) modeling. The cross validation
of the data for the reduction in uptake of Hg(II) ions in the plant R. sativus grown in soil and sand culture in presence of selenium has been used for ANN modeling. ANN model based on the combination
of back propagation and principal component analysis was able to predict the reduction in Hg uptake with a sigmoid axon transfer
function. The data of fifty laboratory experimental sets were used for structuring single layer ANN model. Series of experiments
resulted into the performance evaluation based on considering 20% data for testing and 20% data for cross validation at 1,500
Epoch with 0.70 momentums The Levenberg–Marquardt algorithm (LMA) was found as the best of BP algorithms with a minimum mean
squared error at the eighth place of the decimal for training (MSE) and cross validation. 相似文献
46.
Modifications to antibody affinity electrophoresis for improved detection of proteins have been developed. The bifunctional linker glutaraldehyde is added to the polyacrylamide gel solution for better incorporation of the bait antibody into a distinct region of a 10% w/v polyacrylamide gel. The addition of glutaraldehyde alleviates the need of an electrophoresis buffer with a specific pH. The protein sample to be analyzed is treated with 2% w/v sodium dodecyl sulfate (SDS) to ensure that they carry a negative charge. The negative charge will allow the proteins to migrate towards the cathode and hence pass through the area embedded with the bait antibody. It is observed that electrophoretic migration of bovine serum albumin (BSA) or protein G ceases upon encounter with anti-BSA whereas proteins ovalbumin, beta-lactoglobulin A, and myoglobin migrate freely. However, the addition of 0.1% w/v SDS in the native gel running buffer disrupts the antibody-antigen bond and neither BSA nor protein G can be captured by anti-BSA. 相似文献
47.
48.
S. K. Chatterjee Mamta Chhabra Shalini Johri 《Journal of polymer science. Part A, Polymer chemistry》1994,32(6):1169-1174
Interpolymer complexes of methacrylic acid-acrylamide copolymer have been prepared by the interaction of its comonomer units with two different homopolymers, and also with a single homopolymer. The stability constants and related thermodynamic parameters (e.g., ΔH0 and ΔS0) of the mixed complex were found to be significantly different from the single homopolymer complexes. This has been attributed to neighboring group influence and destabilization of various interacting forces at different temperatures. © 1994 John Wiley & Sons, Inc. 相似文献
49.
P. Delphia Shalini Rosalyn P. Kannan G. Vinitha 《Journal of Physics and Chemistry of Solids》2007,68(9):1812-1820
A novel structurally isomeric and free-radically polymerizable methacrylates bearing azo-naphthol group in the side chain spaced away from the backbone by a hexamethylene spacer and substituted in 4-position with electron-withdrawing and donating substituent were synthesized for NLO applications. These polymers were characterized by UV, IR, 1H-NMR and 13C-NMR spectroscopy. The photoisomerization properties of all the polymers were studied. The glass transition temperature and thermal stability of the polymers were investigated by DSC and TGA, respectively. The third-order nonlinear optical properties of the polymer film were measured by the Z-scan technique using Ar-ion laser and exhibits negative optical nonlinearity. The results revealed that these polymers possess potential applications in nonlinear optics. 相似文献
50.
Lee BS Krisnanchettiar S Lateef SS Gupta S 《Rapid communications in mass spectrometry : RCM》2005,19(7):886-892
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to detect biotinylated peptides captured by avidin functional affinity electrophoresis (AFAEP). Peptide samples loaded onto AFAEP were heated with sodium dodecyl sulfate to ensure that the peptides are negatively charged, and thus migrate electrophoretically toward the cathode through the embedded avidin zone in the middle of the gel. To detect the biotinylated peptides, the band containing the avidin-biotinylated peptide complexes was excised from a 7.5% w/v native polyacrylamide gel, and biotinylated peptides were extracted with aqueous 95% v/v formamide (pH 8.2), aqueous 6 M guanidine HCl (pH 1.5), or water, at temperatures from 4 to 95 degrees C for periods from 5 min to 24 h. It was observed that all three solvents are capable of extracting biotinylated peptides and avidin from the gel, but the best results were obtained with aqueous 95% v/v formamide (pH 8.2) at 65 degrees C for 20 min. However, some AFAEP-captured biotinylated peptides are not stable and are extensively modified by formamide during extraction at too high a temperature or too long an extraction time. 相似文献