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991.
If G is a finite abelian group and k > 1 is an integer, we say that G has the Hajós k-property, if from each factorization G = A 1 A 2···A k of G into direct product of subsets, it follows that at least one of the subsets A i is periodic, in the sense that there exists x ∊ G − {e} such that xA i = A i . In this paper, we shall study 2-groups with respect to this property.  相似文献   
992.
Solid formulas obtained between furosemide and two β-cyclodextrin derivatives (HP-β-CD and RAMEB) were prepared by different methods and in various ratios (1:1 and 1:2). The inclusion complex formation between the drug and the β-CDs of 1:1 ratio was evaluated by mean of thermal analysis (DSC, TG and EGD). Supplementary techniques, such as X-ray diffraction, were also applied to interpret the results of the thermal study of physically mixed and kneaded products. Both studies demonstrated the formation of inclusion complexes in all samples except the physical mix samples; formation of true inclusion complexes was then possible only when the components were in melted form. The complexation increased the solubility and the rate of dissolution of the drug. RAMEB was found to be a better complexing agent than HP-β-CD; in both ratios it can be selected as a vehicle in furosemide tablet preparations. This revised version was published online in August 2006 with corrections to the Cover Date.  相似文献   
993.
 A simple, rapid, accurate and sensitive spectrophotometric method for the determination of norfloxacin (NRF), ofloxacin (OFL) and ciprofloxacin (CPF) is described. This method is based on the formation of an ion pair with sudan III in aqueous-acetone medium [40% (v/v) acetone]. The coloured products are measured at 567, 565 and 566 nm for NRF, OFL and CPF, respectively. The optimization of various experimental conditions is described. Beer’s law is obeyed in the range 0.4–12.0, 0.4–8.8 and 0.4–10.4  ;μg mL−1 of NRF, OFL and CPF, respectively. For more accurate results, Ringbom optimum concentration ranges were 0.8–11.2, 0.6–8.5 and 0.8–10.0 μg mL−1, respectively. The results obtained showed good recoveries of ±1.2, ±1.5 and ±1.7% with relative standard deviations of 0.67, 0.83 and 1.08% for NRF, OFL, and CPF, respectively. The molar absorptivity and Sandell sensitivity were also calculated. Applications of the proposed method to representative pharmaceutical formulations are successfully presented. Received April 30, 1999. Revision November 25, 1999.  相似文献   
994.
S-(–)-1-phenylethylamide of 6-bromo-4-hydroxy-1-isoamyl-2-oxo-3-quinolinecarboxylic acid was synthesized. X-ray diffraction investigation of this product was carried out to determine its absolute configuration.For communication 38, see ref. [1].National Pharmaceutical Academy of Ukraine, 310002 Kharkov, Ukraine Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 64–69, January, 2000.  相似文献   
995.
The crystal structure of the title compound, [Sn4(C4H9)8(C10H6NO4)4O2], contains centrosymmetric dimers. It contains a central Sn2O2 core with the O atoms bonded to two di­butyl­bis(N‐phthaloyl­glycinato)­tin units. The Sn atoms of the core are six‐coordinate in a skew trapezoidal bipyramidal geometry, while the exocyclic Sn atoms are essentially five‐coordinate in a distorted trigonal geometry. The Sn—C distances lie in a narrow range of 2.120 (5)–2.138 (4) Å.  相似文献   
996.
A small series of nitro group-bearing enamides was designed, synthesized (NEA1–NEA5), and evaluated for their inhibitory profiles of monoamine oxidases (MAOs) and β-site amyloid precursor protein cleaving enzyme 1 (β-secretase, BACE1). Compounds NEA3 and NEA1 exhibited a more potent MAO-B inhibition (IC50 value = 0.0092 and 0.016 µM, respectively) than the standards (IC50 value = 0.11 and 0.14 µM, respectively, for lazabemide and pargyline). Moreover, NEA3 and NEA1 showed greater selectivity index (SI) values toward MAO-B over MAO-A (SI of >1652.2 and >2500.0, respectively). The inhibition and kinetics studies suggested that NEA3 and NEA1 are reversible and competitive inhibitors with Ki values of 0.013 ± 0.005 and 0.0049 ± 0.0002 µM, respectively, for MAO-B. In addition, both NEA3 and NEA1 showed efficient BACE1 inhibitions with IC50 values of 8.02 ± 0.13 and 8.21 ± 0.03 µM better than the standard quercetin value (13.40 ± 0.04 µM). The parallel artificial membrane permeability assay (PAMPA) method demonstrated that all the synthesized derivatives can cross the blood–brain barrier (BBB) successfully. Docking analyses were performed by employing an induced-fit docking approach in the GLIDE module of Schrodinger, and the results were in agreement with their in vitro inhibitory activities. The present study resulted in the discovery of potent dual inhibitors toward MAO-B and BACE1, and these lead compounds can be fruitfully explored for the generation of newer, clinically active agents for the treatment of neurodegenerative disorders.  相似文献   
997.
Access to asymmetrically functionalized polyoxometalates is a grand challenge as it could lead to new molecular nanomaterials with multiple or modular functionality. Now, a simple one‐pot synthetic approach to the isolation of an asymmetrically functionalized organic–inorganic hybrid Wells–Dawson polyoxometalate in good yield is presented. The cluster bears two organophosphonate moieties with contrasting physical properties: a chelating metal‐binding group, and a long aliphatic chain that facilitates solvent‐dependent self‐assembly into soft nanostructures. The orthogonal properties of the modular system are effectively demonstrated by controlled assembly of POM‐based redox‐active nanoparticles. This simple, high‐yielding synthetic method is a promising new approach to the preparation of multi‐functional hybrid metal oxide clusters, supermolecular systems, and soft‐nanomaterials.  相似文献   
998.
Journal of Radioanalytical and Nuclear Chemistry - Although the coral island ‘St. Martin’s’ serves as the most attractive place for leisure and tourism, but no data on...  相似文献   
999.

Various composite adsorbents based on sulfonated poly(ether ether ketone)/manganese dioxide were prepared for the removal of stable and radioactive ions from contaminated aqueous solution. Batch adsorption experiments revealed superior adsorption capacities of the composite using very low initial concentration of studied elements. Starting with 1000 µg L−1 contaminated solution, the maximum equilibrium metal uptake capacity reached 2.0 mg g−1 for Pb2+, 1.9 mg g−1 for Cd2+, Cu2+ and Zn2+, and 3.7 mg g−1 for Co2+. In addition, the distribution coefficient reached 11,600 mL g−1 for 137Cs and 70,000 mL g−1 for 210Pb.

  相似文献   
1000.
Paul  A.  Mandal  G.  Mamun  A. A.  Amin  M. R. 《Physics of Wave Phenomena》2019,27(4):261-267

A self-gravitating opposite polarity dust plasma (SGOPDP) medium (containing both positively and negatively charged dust, vortex-like distributed ions and Maxwellian electrons) has been considered in order to examine the effect of vortex-like (trapped) ion distribution on dust-acoustic (DA) solitary waves (SWs) propagating in SGOPDP medium. The reductive perturbation method, which is valid for small but finite amplitude SWs, is employed to derive a modified Korteweg-de Vries equation having stronger nonlinearity. The basic features of the DA SWs in SGOPDP medium are found to be significantly modified by the combined effect of self-gravitational field and vortex-like ion distribution. The results of this paper have many implications in space and laboratory dusty plasmas.

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