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131.
Ali Altharawi Khalid M. Alharthy Hassan N. Althurwi Faisal F. Albaqami Sami I. Alzarea Fahad A. Al-Abbasi Muhammad Shahid Nadeem Imran Kazmi 《Molecules (Basel, Switzerland)》2022,27(21)
Background: Europinidin is a derivative of delphinidin obtained from the plants Plumbago Europea and Ceratostigma plumbaginoides. This herb has wide medicinal applications in treating various diseases but there are very few studies available on this bioactive compound. Considering this background, the present study is designed for the evaluation of Europinidin against Parkinson’s disease. Aim: The investigation aims to assess the effect of Europinidin in the rotenone-activated Parkinson’s paradigm. Methods: To evaluate neuroprotective activity, rotenone (1.5 mg/kg s.c) and europinidin (10 mg/kg and 20 mg/kg) was administered in rats for 21 days. The behavioural parameters were performed before sacrificing the rats. On the 22nd day, all the rats were assessed for biochemical markers (SOD, GSH, MDA, Catalase), neurotransmitter levels (Dopamine, 5-HIAA, DOPAC, and HVA levels), and neuroinflammatory markers (IL-6, IL-1β and TNF-α). Results: It was found that rotenone produced significant (p < 0.001) oxidative damage, a cholinergic deficit, dopaminergic loss, and a rise in neuroinflammatory markers in rats. Conclusion: The study concludes that europinidin possesses anti-oxidant and anti-inflammatory properties. The results suggest the therapeutic role of europinidin against rotenone-activated behavioural, biochemical, and neuroinflammatory alterations in rats. 相似文献
132.
Shahid Ali Khurshid Ahmad Sibhghatulla Shaikh Jeong Ho Lim Hee Jin Chun Syed Sayeed Ahmad Eun Ju Lee Inho Choi 《Molecules (Basel, Switzerland)》2022,27(13)
Myostatin (MSTN), a negative regulator of muscle mass, is reported to be increased in conditions linked with muscle atrophy, sarcopenia, and other muscle-related diseases. Most pharmacologic approaches that treat muscle disorders are ineffective, emphasizing the emergence of MSTN inhibition. In this study, we used computational screening to uncover natural small bioactive inhibitors from the Traditional Chinese Medicine database (~38,000 compounds) for the MSTN protein. Potential ligands were screened, based on binding affinity (150), physicochemical (53) and ADMET properties (17). We found two hits (ZINC85592908 and ZINC85511481) with high binding affinity and specificity, and their binding patterns with MSTN protein. In addition, molecular dynamic simulations were run on each complex to better understand the interaction mechanism of MSTN with the control (curcumin) and the hit compounds (ZINC85592908 and ZINC85511481). We determined that the hits bind to the active pocket site (Helix region) and trigger conformational changes in the MSTN protein. Since the stability of the ZINC85592908 compound was greater than the MSTN control, we believe that ZINC85592908 has therapeutic potential against the MSTN protein and may hinder downstream singling by inhibiting the MSTN protein and increasing myogenesis in the skeletal muscle tissues. 相似文献
133.
Nida Iftikhar Ammara Saleem Muhammad Furqan Akhtar Ghulam Abbas Shahid Shah Shabana Bibi Ghulam Md Ashraf Badrah S. Alghamdi Turki S. Abujamel 《Molecules (Basel, Switzerland)》2022,27(19)
Present research was planned to assess the in vitro and in vivo anti-arthritic potential of Caralluma tuberculata N. E. Brown. methanolic (CTME) and aqueous (CTAQ) extracts. Chemical characterization was done by high-performance liquid chromatography and gas chromatography–mass spectrometry analysis. The Complete Freund’s Adjuvant (CFA) was injected in left hind paw of rat at day 1 and dosing at 150, 300 and 600 mg/kg was started on the 8th day via oral gavage in all groups except normal and disease control rats (which were given distilled water), whereas methotrexate (intraperitoneal; 1 mg/kg/mL) was administered to standard control. The CTME and CTAQ exerted significant (p < 0.01–0.0001) in vitro anti-arthritic action. Both extracts notably reduced paw edema, and restored weight loss, immune organs weight, arthritic score, RBCs, ESR, platelet count, rheumatoid factor (RF), C-reactive protein, and WBCs in treated rats. The plant extracts showed significant (p < 0.05–0.0001) downregulation of tumor necrosis factor-α, Interleukin-6, -1β, NF-κB, and cyclooxygenase-2, while notably upregulated IL-4, IL-10, I-κBα in contrast to disease control rats. The plant extracts noticeably (p < 0.001–0.0001) restored the superoxide dismutase and catalase activities and MDA levels in treated rats. Both extracts exhibited significant anti-arthritic potential. The promising potential was exhibited by both extracts probably due to phenolic, and flavonoids compounds. 相似文献
134.
Dr. Shenghua Chen Dr. Chengliang Ye Dr. Ziwei Wang Dr. Peng Li Dr. Wenjun Jiang Dr. Zechao Zhuang Dr. Jiexin Zhu Dr. Xiaobo Zheng Dr. Shahid Zaman Dr. Honghui Ou Lei Lv Dr. Lin Tan Dr. Yaqiong Su Dr. Jiang Ouyang Prof. Dingsheng Wang 《Angewandte Chemie (International ed. in English)》2023,62(50):e202315621
Electrochemical CO2 reduction reaction (CO2RR) over Cu catalysts exhibits enormous potential for efficiently converting CO2 to ethylene (C2H4). However, achieving high C2H4 selectivity remains a considerable challenge due to the propensity of Cu catalysts to undergo structural reconstruction during CO2RR. Herein, we report an in situ molecule modification strategy that involves tannic acid (TA) molecules adaptive regulating the reconstruction of a Cu-based material to a pathway that facilitates CO2 reduction to C2H4 products. An excellent Faraday efficiency (FE) of 63.6 % on C2H4 with a current density of 497.2 mA cm−2 in flow cell was achieved, about 6.5 times higher than the pristine Cu catalyst which mainly produce CH4. The in situ X-ray absorption spectroscopy and Raman studies reveal that the hydroxyl group in TA stabilizes Cuδ+ during the CO2RR. Furthermore, theoretical calculations demonstrate that the Cuδ+/Cu0 interfaces lower the activation energy barrier for *CO dimerization, and hydroxyl species stabilize the *COH intermediate via hydrogen bonding, thereby promoting C2H4 production. Such molecule engineering modulated electronic structure provides a promising strategy to achieve highly selective CO2 reduction to value-added chemicals. 相似文献
135.
Mirza Nadeem Ahmad Sohail Nadeem Mohsin Javed Shahid Iqbal Sadaf ul Hassan Samar O. Aljazzar Eslam B. Elkaeed Rami Adel Pashameah Eman Alzahrani Abd-ElAziem Farouk Mohammed T. Alotaibi Hisham S. M. Abd-Rabboh 《Molecules (Basel, Switzerland)》2022,27(17)
The synthesis of MMT and poly(o-anisidine) (MMT/POA) clay nanocomposites was carried out by using the chemical oxidative polymerization of POA and MMT clay with POA, respectively. By maintaining the constant concentration of POA, different percentage loads of MMT clay were used to determine the effect of MMT clay on the properties of POA. The interaction between POA and MMT clay was investigated by FTIR spectroscopy, and, to reveal the complete compactness and homogeneous distribution of MMT clay in POA, were assessed by using scanning-electron-microscope (SEM) analysis. The UV–visible spectrum was studied for the optical and absorbance properties of MMT/POA ceramic nanocomposites. Furthermore, the horizontal burning test (HBT) demonstrated that clay nanofillers inhibit POA combustion. 相似文献
136.
137.
Nonlinear Dynamics - Middle East Respiratory Syndrome Coronavirus (MERS-CoV) can cause mild to severe acute respiratory illness with a high mortality rate. As of January 2020, more than 2500 cases... 相似文献
138.
Nasuha Siti Pershaanaa M. Bashir Shahid Ramesh K. Ramesh S. 《Journal of Solid State Electrochemistry》2022,26(8):1733-1746
Journal of Solid State Electrochemistry - Binary metal sulfide–based electrode materials with distinct nanoarchitecture, improved conductivities, and fascinating mechanical stabilities are... 相似文献
139.
M. Shahid Rafique Shazia Bashir Ali Ajami Wolfgang Husinsky 《Applied Physics A: Materials Science & Processing》2010,100(4):1183-1189
We have investigated femtosecond laser irradiation effects on the surface topography, structural changes and nonlinear absorption
properties of CR-39. For this purpose, a CR-39 target was exposed in air to 25 fs, 800 nm Ti: sapphire laser radiation at
fluences ranging from 0.25 J cm−2 to 3.6 J cm−2. The surface of irradiated CR-39 probed by an Atomic Force Microscope (AFM) exhibits the formation of several topographical
structures, like bumps, explosions and nano cavities. Raman spectroscopy is performed to explore chemical and structural modification
of the irradiated target. The spectroscopy reveals changes such as cross linking, bond breaking, formation of new bonds etc.
in the fundamental structure of the polymer after irradiation. In order to establish a correlation between morphological and
structural changes with the changes in the nonlinear absorption of the irradiated CR-39, a Z-scan technique was employed.
A comparison of experimentally obtained data from Z-scan measurements with our calculations predicts the dominance of three-photon
absorption in the case of pristine CR-39, whereas for irradiated targets concurrence of three- and two-photon absorption is
probable. Nonlinear absorption increases with increasing laser fluences and is well correlated by surface and structural changes
revealed by AFM and Raman spectroscopy. 相似文献
140.