Reported is the first method to prepare a new class of thienopyrazole thioglycosides via a one‐pot reaction of the sodium thienopyrazolthiolate salts with 2,3,4,6‐tetra‐O‐acetyl‐α‐D‐gluco‐and galactopyranosyl bromides. The sodium thienopyrazolthiolate salts are prepared using pyrazoldithioic acids and their corresponding mono ‐ and dithiolate salts. 相似文献
JPC – Journal of Planar Chromatography – Modern TLC - A novel HPTLC method has been developed for the estimation of glabridin in Licorice rhizome and its Unani polyherbal formulation... 相似文献
Naringenin (Nar) is an important bioactive flavonoid with poor organic solubility and oral bioavailability. It is highly promising for treatment of conditions including diabetes, hyperlipidemia, and hepatitis C infection. Amorphous solid dispersion (ASD) of Nar is an appealing way to enhance its solubility, and carboxylated cellulose esters are attractive polymers for this purpose because of their ability to stabilize drugs against crystallization in both solid and solution phases, while restricting drug release to the pH of the small intestine (ca. 6.8). We demonstrate that ASDs of Nar can be formed using such carboxylated cellulose derivatives as cellulose acetate adipate propionate (CAAdP), carboxymethylcellulose acetate butyrate (CMCAB) and hydroxypropylmethylcellulose acetate succinate (HPMCAS). We compare Nar solution concentrations and release profiles from these cellulosic ASDs to those from pure crystalline Nar, and to Nar ASD in poly(vinylpyrrolidinone) (PVP). We show that all polymers in this study form ASDs with Nar, that the PVP ASDs release Nar at both gastric (1.2) and small intestine (6.8) pH, and that the cellulosic polymers release Nar selectively at neutral pH. Solution concentrations of Nar are significantly enhanced from these ASDs. These preliminary studies indicate that HPMCAS, CAAdP, and CMCAB are practical ASD polymers for Nar due to their ability to generate and stabilize high solution concentrations, and their pH-triggered drug release. 相似文献
Organotin complexes have been synthesized by refluxing 2-mercapto-5-methyl benzimidazole with R2SnCl2/R3SnCl (R = Me, n-Bu, Ph) in 1:1 molar ratio in the first step. In the second step, synthesized organotin(IV) complexes were treated with CS2 and R2SnCl2/R3SnCl/PdCl2 to yield homo- and heterobimetallic complexes. The composition of the synthesized complexes, the bonding behavior of the donor groups, and structural assignments were studied by elemental analysis and different spectral techniques, including IR and multinuclear NMR (1H, 13C). The IR data shows bidentate nature of the ligand which is also confirmed by semiempirical study, while NMR data confirms the four-coordinated geometry in solution. The free ligand and its respective homo- and heterobimetallic complexes were screened in vitro against a number of microorganisms to assess their biocidal properties. The biological activity data show that complexes exhibits significant antibacterial and antifungal activities as compared to ligand with few exceptions. 相似文献
Copolymers of N‐isopropylacrylamide (NIPAM) and dopamine methacrylate can establish a reversible, self‐healing 3D network in aprotic solvents based on hydrogen bonding. The reactivity and hydrogen bonding formation of catechol groups in copolymer chains are studied by UV–vis and 1H NMR spectroscopy, while reversibility from sol to gel and inverse as well as self‐healing properties are tested rheologically. The produced reversible organogel can self‐encapsulate physically interacting or chemically bonded solutes such as drugs due to thermosensitivity of the used copolymer. This system offers dual‐targeted and controlled drug delivery and release—by slowing down release kinetics by supramolecular bonding of the drug and by reducing diffusion rates due to modulus increase.
Journal of Thermal Analysis and Calorimetry - Nanofluids have recently attracted attention of many researchers due to their growing potential applications in heat transfer devices. They possess... 相似文献
Journal of Thermal Analysis and Calorimetry - The ultimate goal of the present review paper is to summarize and discuss the findings of the most recently published literature on natural convection... 相似文献
Russian Journal of General Chemistry - A highly efficient synthetic methodology for the preparation of 2-thioxocytosine was achieved by the nucleophilic addition of thiourea to... 相似文献
Journal of Thermal Analysis and Calorimetry - The selective drug delivery system could be an excellent alternative to fight cancer and pathogens, due to its minimized negative consequences.... 相似文献
We consider a model for magnetic memory that consists of strongly coupled dipolar or antiferromagnetic (AF) pairs with inequivalent perpendicular anisotropy K1 and K2. For appropriate parameter values, determined in this work, they have two inequivalent storage states with zero net magnetic moment. Both analytical and numerical calculations are performed, in some cases yielding different results because of relaxation effects (i.e., a dependence on the damping parameter α). Hysteresis loops for a wide variety of parameter values are obtained, both for the AF case and the dipole case. An Appendix gives analytic results for slightly non-collinear spins in an applied field, which were used to test the numerical results. 相似文献