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71.
A novel one-pot pseudo five-component reaction of isocyanides with 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione and various aliphatic and aromatic aldehydes in ethanol at room temperature has been studied. 2,6-Bis(alkylamino)-benzofuro[5,6-b]furan-4,8-dione derivatives were isolated as the products in good yields after 24 h. 相似文献
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Andersen NH Olsen KA Fesinmeyer RM Tan X Hudson FM Eidenschink LA Farazi SR 《Journal of the American Chemical Society》2006,128(18):6101-6110
Minimized beta hairpins have provided additional data on the geometric preferences of Trp interactions in TW-loop-WT motifs. This motif imparts significant fold stability to peptides as short as 8 residues. High-resolution NMR structures of a 16- (KKWTWNPATGKWTWQE, DeltaG(U)(298) >or= +7 kJ/mol) and 12-residue (KTWNPATGKWTE, DeltaG(U)(298) = +5.05 kJ/mol) hairpin reveal a common turn geometry and edge-to-face (EtF) packing motif and a cation-pi interaction between Lys(1) and the Trp residue nearest the C-terminus. The magnitude of a CD exciton couplet (due to the two Trp residues) and the chemical shifts of a Trp Hepsilon3 site (shifted upfield by 2.4 ppm due to the EtF stacking geometry) provided near-identical measures of folding. CD melts of representative peptides with the -TW-loop-WT- motif provided the thermodynamic parameters for folding, which reflect enthalpically driven folding at laboratory temperatures with a small DeltaC(p) for unfolding (+420 J K(-)(1)/mol). In the case of Asx-Pro-Xaa-Thr-Gly-Xaa loops, mutations established that the two most important residues in this class of direction-reversing loops are Asx and Gly: mutation to alanine is destabilizing by about 6 and 2 kJ/mol, respectively. All indicators of structuring are retained in a minimized 8-residue construct (Ac-WNPATGKW-NH(2)) with the fold stability reduced to DeltaG(U)(278) = -0.7 kJ/mol. NMR and CD comparisons indicate that -TWXNGKWT- (X = S, I) sequences also form the same hairpin-stabilizing W/W interaction. 相似文献
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Shabnam Saberi Biroon Nahid Shajari Hooriye Yahyaei 《Journal of heterocyclic chemistry》2020,57(6):2433-2445
The one-pot three-component synthesis for the preparation of 1H-indazolo[1,2-b] phthalazine-1,6,11(13H)-triones through condensation of phthalimide, hydrazine monohydrate, dimedone, and aromatic aldehydes in the presence of a novel catalytic amount of ZrO(NO3)2.2H2O at reflux conditions in water has been reported. Quantum theoretical calculations for the three structures of compounds ( 5a , 5b , and 5c ) were performed using the G3MP2, LC-ωPBE, MP2, and B3LYP methods with the 6-311 + G** basis set. After optimizing the structures, geometric parameters were obtained and experimental measurements were compared with the calculated data. The structures of the products were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. IR spectra data and 1H NMR and 13C NMR chemical shifts computations of the 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives in the ground state were calculated. Frontier molecular orbitals, total density of states, thermodynamic parameters, and molecular electrostatic potentials of the title compounds were investigated by theoretical calculations. Molecular properties such as the ionization potential (I), electron affinity (A), chemical hardness (η), electronic chemical potential (μ), and electrophilicity (ω) were investigated for the structures. Consequently, there was an excellent agreement between experimental and theoretical results. 相似文献
75.
Shabnam Shahida Akbar Ali Muhammad Haleem Khan 《Journal of the Iranian Chemical Society》2014,11(1):1-8
A very sensitive, selective and simple flow injection time-based method was developed for on-line preconcentration and determination of thorium(IV) at micro g L–1 levels in environmental samples. The system operation was based on thorium(IV) ion retention at pH 4.0 in the minicolumn at a flow rate of 15.2 mL min–1. The trapped complex was then eluted with 3.6 mol L–1 HCl at a flow rate of 4.9 mL min–1. The amount of thorium(IV) in the eluate was measured spectrophotometrically at 651 nm using arsenazo-III solution (0.05 % in 3.6 mol L–1 HCl stabilized with 1 % triton X-100, 4.9 mL min–1) as colorimetric reagent. All chemical, and flow injection variables were optimized for the quantitative preconcentration of metal and a study of interference level of various ions was also carried out. The system offered low backpressure and improved sensitivity and selectivity. At a preconcentration time of 60 s and a sample frequency of 40 h–1, the enhancement factor was 97, the detection limit was 0.25 μg L–1, and the precision expressed as relative standard deviation was 1.08 % (at 50 μg L–1), whereas for 300 s of the preconcentration time and a sample frequency of 10 h–1, the enhancement factor of 357, the detection limit (3σ) of 0.069 μg L–1 and the precision of 1.32 % (at 10 μg L–1) was reported. The accuracy of the developed method was sufficient and evaluated by the analysis of certified reference material IAEA-SL-1 (Lake Sediment) and spiked water samples. 相似文献
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Angelina Osipyan Shabnam Shaabani Robert Warmerdam Svitlana V. Shishkina Harry Boltz Alexander Dmling 《Angewandte Chemie (International ed. in English)》2020,59(30):12423-12427
Miniaturization and acceleration of synthetic chemistry is an emerging area in pharmaceutical, agrochemical, and materials research and development. Herein, we describe the synthesis of iminopyrrolidine‐2‐carboxylic acid derivatives using chiral glutamine, oxo components, and isocyanide building blocks in an unprecedented Ugi‐3‐component reaction. We used I‐DOT, a positive‐pressure‐based low‐volume and non‐contact dispensing technology to prepare more than 1000 different derivatives in a fully automated fashion. In general, the reaction is stereoselective, proceeds in good yields, and tolerates a wide variety of functional groups. We exemplify a pipeline of fast and efficient nanomole‐scale scouting to millimole‐scale synthesis for the discovery of a useful novel reaction with great scope. 相似文献
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We investigate the structure of singular Calabi–Yau varieties in moduli spaces that contain a Brieskorn–Pham point. Our main tool is a construction of families of deformed motives over the parameter space. We analyze these motives for general fibers and explicitly compute the L-series for singular fibers for several families. We find that the resulting motivic L-functions agree with the L-series of modular forms whose weight depends both on the rank of the motive and the degree of the degeneration of the variety. Surprisingly, these motivic L-functions are identical in several cases to L-series derived from weighted Fermat hypersurfaces. This shows that singular Calabi–Yau spaces of non-conifold type can admit a string worldsheet interpretation, much like rational theories, and that the corresponding irrational conformal field theories inherit information from the Gepner conformal field theory of the weighted Fermat fiber of the family. These results suggest that phase transitions via non-conifold configurations are physically plausible. In the case of severe degenerations we find a dimensional transmutation of the motives. This suggests further that singular configurations with non-conifold singularities may facilitate transitions between Calabi–Yau varieties of different dimensions. 相似文献
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Shabnam Fakhari Azita Nouri Mina Jamzad Samira Arab‐Salmanabadi Foujan Falaki 《中国化学会会志》2021,68(1):67-75
In this study, the density functional theory computational method is used to investigate the encapsulation process of metformin into three types of the cyclic peptides composed of eight serine (CP1), eight glycine (CP2), and four serine‐glycine (CP3) cyclic peptides as a new model in the process of drug delivery in the gas phase. The obtained results using the B3LYP/6‐31++G (d,p) method indicate that the complexes formed are energetically favored. Furthermore, results reveal that the drug encapsulation process is typically chemisorption. The natural bonding orbital analysis shows that the intermolecular interaction of the C2 complex (metformin/CP2) is stronger than the C1 (Metformin/CP1) and C3 (Metformin/CP3) complexes due to greater total charge transfer energy, and the C1 complex is found to be the most favored complex. The theory of atoms in molecule (AIM) method is used to analyze the nature of interactions in different molecular systems. The results show the investigated cyclic peptides as effective carriers of metformin in the nanomedicine field. 相似文献
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Russian Journal of Organic Chemistry - Two fluorescent heterocyclic ligands were obtained by reduction of imidazo[4,5-e][2,1]benzoxazole derivatives with Fe/HCl. New fluorescent nickel(II)... 相似文献