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941.
A liquid chromatographic chiral stationary phase (CSP) based on (3,3'-diphenyl-1,1'-binaphthyl)-20-crown-6, which has been utilized in the resolution of alpha-amino acids, amines and amino alcohols, was treated with excess of n-octyltriethoxysilane to prepare a new improved CSP. The residual silanol groups of the original CSP were protected by n-octyl groups in the new CSP. The chiral recognition ability of the new CSP was superior to that of the original CSP in the resolution of alpha-amino acids, amines and amino alcohols. Retention factors (k1) for the resolution of alpha-amino acids were lower on the new CSP than on the original CSP while those for the resolution of amines and amino alcohols were higher on the new CSP than on the original CSP. The improved chiral recognition ability of the new CSP and the retention behaviors of the two enantiomers on the new CSP have been rationalized to stem from the removal of the non-enantioselective interactions between the analytes and the residual silanol groups of the original CSP and the improved lipophilicity of the CSP. 相似文献
942.
Schmitt M Wagner J Jung G Hempelmann R 《Journal of colloid and interface science》2007,311(2):425-429
Polymer colloids are prepared via radicalic emulsion polymerisation of butylacrylate. Functionalization with amino groups is achieved by copolymerisation of 2-amino-ethylmethacrylates. In order to over-compensate the positive surface charges resulting from the amino groups additionally vinylbenzenesulfonic acid is copolymerized. The size of the resulting particles is controlled by the molar ratio of amino to sulfonic acid groups. The suitability of amino groups for coupling reactions is demonstrated by electrophilic addition of fluorescein-5-isothiocyanate. The resulting particles are characterized by dynamic light scattering and zeta potential measurements as well as by optical spectroscopy. The suitability of labelled particles for optical tracer experiments is demonstrated by fluorescence correlation spectroscopy. 相似文献
943.
The distinct signaling mechanisms of microbial sensory rhodopsins in Archaea, Eubacteria and Eukarya
Jung KH 《Photochemistry and photobiology》2007,83(1):63-69
Most of the known archaeal-type microbial rhodopsins are retinal-binding ion transporters, such as bacteriorhodopsin (BR) and proteorhodopsin (PR). Their identification is the result of extensive studies of their photochemical and biophysical properties. The cells containing these pigments, however, use other microbial rhodopsins as photosensors to monitor environmental light signals. From the early studies of sensory rhodopsin I (HsSRI) in Halobacterium salinarum and sensory rhodopsin II (NpSRII) in Natronomonas pharaonis, we now know that several microbial sensory rhodopsins in the other major domain of life relay information on light intensity and quality to the cell. Three of the most studied photosensory transduction mechanisms of these microbial rhodopsins are dealt with in this review. We discuss recent progress in the understanding of genomic organization, photochemical properties and photosignaling mechanisms with respect to biological function. 相似文献
944.
Seo SY Jung JW Jung JK Kim NJ Chin YW Kim J Suh YG 《The Journal of organic chemistry》2007,72(2):666-668
Rodgersinol was synthesized via seven linear steps in 31% overall yield, and the absolute configuration of the C-10 stereogenic center was elucidated. The key feature of the synthesis involves the efficient Cu(II)-mediated coupling of two aromatic moieties for the diaryl ether intermediate and the enantioselective construction of the hydroxypropyl substituent by a regio- and stereoselective methyl addition to the chiral aryloxiranes in an inversion manner. 相似文献
945.
A new efficient method for the synthesis of geometrically pure (E)-alkenes from (Z)-alkenes is described. The reaction of aryl- or alkyl-substituted (Z)-alkenes with tributyltin hydride and triethylamine in the presence of a catalytic amount of palladium acetate afforded the corresponding (E)-alkenes in good yields. 相似文献
946.
D. Hofmann K. Jung H.-J. Segschneider M. Gehre G. Schüürmann 《Isotopes in environmental and health studies》2013,49(3-4):367-375
Abstract In order to perform the 15N/14N analysis of amino acids using a gas chromatograph and isotope ratio mass spectrometer linked up via a combustion interface (GC-C-IRMS), the amino acids must be derivatized. Tert-butyldimethylsilylation is examined using various techniques (direct conversion to nitrogen gas, ConFlo-IRMS [1], GC-C-IRMS [2]) and subsequently applied to isotopic characterization of amino acids from wheat protein hydrolyzate obtained from plants exposed to ozone. The method provides a reliable tool for studying ecotoxicological effects on plants at a molecular level in addition to the investigation of the natural variations of different N fractions. 相似文献
947.
We have recently developed a new type of liquid junction-free reference electrode that is suited for fabrication of miniature ion sensor devices. The proposed reference electrode system employs a solvent-processible polymer membrane, and the best performance membrane so far is formulated with an aromatic type polyurethane,synthesized with 4,4'- methylenebis(phenyl isocyanate) and poly(tetramethylene ether glycol). 相似文献
948.
Young-Dae Jung 《The European Physical Journal D - Atomic, Molecular, Optical and Plasma Physics》2000,11(2):291-294
The classical electron-ion Coulomb Bremsstrahlung process is investigated in nonideal plasmas. An effective pseudopotential
model taking into account the plasma screening and collective effects is applied to describe the electron-ion interaction
potential in a classical nonideal plasma. The classical straight-line trajectory method is applied to the motion of the projectile
electron in order to visualize the variation of the differential Bremsstrahlung radiation cross-section (DBRCS) as a function
of the scaled impact parameter, nonideal plasma parameter, projectile energy, photon energy, and Debye length. The results
show that the DBRCS in ideal plasmas described by the Debye-Hückel potential is always greater than that in nonideal plasmas,
i.e., the collective effects reduce the DBRCS for both the soft and hard photon cases. For large impact parameters, the DBRCS
for the soft photon case is found to be always greater than that for the hard photon case.
Received 1st December 1999 相似文献
949.
Jürgen M. Kolos Sebastian Pomplun Sascha Jung Benedikt Rieß Patrick L. Purder Andreas M. Voll Stephanie Merz Monika Gnatzy Thomas M. Geiger Ingrid Quist-Lkken Jerome Jatzlau Petra Knaus Toril Holien Andreas Bracher Christian Meyners Paul Czodrowski Vera Krewald Felix Hausch 《Chemical science》2021,12(44):14758
Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic [4.3.1] aza-amides, robustly leading to a 2 to 10-fold increase in binding affinity for FK506-binding proteins (FKBPs). This resulted in the most potent and efficient FKBP ligands known to date. By a combination of co-crystal structures, isothermal titration calorimetry (ITC), density-functional theory (DFT), and 3D reference interaction site model (3D-RISM) calculations we elucidated the origin of the observed affinity boost, which was purely entropically driven and relied on the displacement of a water molecule at the protein–ligand–bulk solvent interface. The best compounds potently occupied FKBPs in cells and enhanced bone morphogenic protein (BMP) signaling. Our results show how subtle manipulation of the solvent network can be used to design atom-efficient ligands for difficult, solvent-exposed binding pockets.Enhancement by displacement. A single methyl group displaces a water molecule from the binding site of FKBPs, resulting in the most potent binders known, outperforming the natural products FK506 and rapamycin in biochemical and cellular assays. 相似文献
950.