Reflection and refraction of attenuated waves in semi-infinite elastic solid media

In earthquakes it is known that waves of one type starting from the origin inside the earth produce waves of other types after impact at the free surface of the earth. A theoretical discussion is given here dealing with reflection and refraction of waves which have their amplitudes increasing with depth similar in nature to the initial diverging earthquake waves which after reflection produce the apparent surface waves in which the displacement decreases with depth. In one case it has been found that at a free surface a plane wave of SV type, travelling parallel to the surface, is capable of generating surface waves after internal reflection which under a certain state of attenuation are identical with the Rayleigh Waves.     

Highly selective colorimetric fluorescence sensor for Cu: cation-induced ‘switching on’ of fluorescence due to excited state internal charge transfer in the red/near-infrared region of emission spectra

A 1,8-naphthalimide-based colorimetric fluorescence perinone dye, receptor 1 is reported herein for the selective detection of Cu²⁺ over the other heavy and transition metal ions. Receptor 1 shows a strong colorimetric change from orange to purple and a dramatic enhancement of fluorescence intensity due to cation-induced excited state internal charge transfer during the sensing event, that is, a dual optical response that would facilitate naked-eye detection of Cu²⁺.     

Developing conceptions of statistics by designing measures of distribution

Students often learn procedures for measuring, but rarely do they grapple with the foundational conceptual problem of generating and validating coordination between a measure and the phenomenon being measured. Coordinating measures with phenomenon involves developing an appreciation of the objects and relations in each as well as establishing their mutual correspondence. We supported students?? developing conceptions of statistics by positioning them to design measures of center and of variability for distributions that they had generated through repeated measure of a length. After students invented and explored the viability of their measures individually, they participated in a public (whole-class conversation) forum featuring justification and reflection about the viability of their designed measures. We illustrate how individual invention enticed students to attend to, and to make explicit, characteristics of distribution not initially noticed or known only tacitly. Conceptions of statistics and of relevant characteristics of distribution were further expanded as students justified and argued about the utility and prospective generalization of particular inventions. Teachers supported student learning by highlighting prospective relations between characteristics of measures and characteristics of distribution as they emerged during the course of activity in each setting.     

Directed evolution of cyclic peptides for inhibition of autophagy

In recent decades it has become increasingly clear that induction of autophagy plays an important role in the development of treatment resistance and dormancy in many cancer types. Unfortunately, chloroquine (CQ) and hydroxychloroquine (HCQ), two autophagy inhibitors in clinical trials, suffer from poor pharmacokinetics and high toxicity at therapeutic dosages. This has prompted intense interest in the development of targeted autophagy inhibitors to re-sensitize disease to treatment with minimal impact on normal tissue. We utilized Scanning Unnatural Protease Resistant (SUPR) mRNA display to develop macrocyclic peptides targeting the autophagy protein LC3. The resulting peptides bound LC3A and LC3B—two essential components of the autophagosome maturation machinery—with mid-nanomolar affinities and disrupted protein–protein interactions (PPIs) between LC3 and its binding partners in vitro. The most promising LC3-binding SUPR peptide accessed the cytosol at low micromolar concentrations as measured by chloroalkane penetration assay (CAPA) and inhibited starvation-mediated GFP-LC3 puncta formation in a concentration-dependent manner. LC3-binding SUPR peptides re-sensitized platinum-resistant ovarian cancer cells to cisplatin treatment and triggered accumulation of the adapter protein p62 suggesting decreased autophagic flux through successful disruption of LC3 PPIs in cell culture. In mouse models of metastatic ovarian cancer, treatment with LC3-binding SUPR peptides and carboplatin resulted in almost complete inhibition of tumor growth after four weeks of treatment. These results indicate that SUPR peptide mRNA display can be used to develop cell-penetrating macrocyclic peptides that target and disrupt the autophagic machinery in vitro and in vivo.

SUPR peptide mRNA display was used to evolve a cell-permeable, macrocyclic peptide for autophagy inhibition.     

Colloidal Microcapsules: Self‐Assembly of Nanoparticles at the Liquid–Liquid Interface

Colloidal microcapsules (MCs) are highly modular, inherently multiscale constructs of capsules stabilized by nano‐/microparticle shells, with applications in many areas of materials and biological sciences, such as drug delivery, encapsulation, and microreactors. Until recently, fabrication of colloidal MCs focused on the use of submicron‐sized particles because the smaller nanoparticles (NPs) are inherently unstable at the interface owing to thermal disorder. However, stable microcapsules can now be obtained by tuning the interactions between the nanometer‐sized building blocks at the liquid–liquid interface. This Review highlights recent developments in the fabrication of colloidal MCs using NPs.     

MHD natural convection flow with radiative heat transfer past an impulsively moving plate with ramped wall temperature

Influence of radiation on unsteady hydromagnetic natural convection transient flow near an impulsively moving vertical flat plate with ramped wall temperature in a porous medium is studied. Exact solution of momentum and energy equations, under Boussinesq approximation, is obtained in closed form by Laplace transform technique. The variations in fluid velocity and temperature are shown graphically whereas numerical values of skin friction and Nusselt number are presented in tabular form.