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961.
S Rosselli M Bruno FM Raimondo V Spadaro M Varol AT Koparal A Maggio 《Molecules (Basel, Switzerland)》2012,17(7):8186-8195
A phytochemical analysis of the dichloromethane extract from the flowers of a subspecies of Tanacetum vulgare growing in Sicily was carried out. Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. All of tested compounds induced high time- and concentration-dependent cytotoxic effects. 相似文献
962.
The photostability of quercetin in alcoholic solutions was studied. Both UVA and UVB light induced degradation of quercetin, yielding a single product 1 deriving from oxidation and addition of an alcohol molecule to the 2,3 double bond. The same mechanism operated when quercetin was dissolved in alkaline solutions, and again a product 2 due to oxidation and addition of water was characterized. Comparison with quercetin analogs confirmed that, despite the presence of five hydroxy groups in quercetin, those in positions 3, 3', and 4' are mainly involved in the antioxidant activity of the compound , as well as in its photolability. 相似文献
963.
Ferrer S Martí S Moliner V Tuñón I Bertrán J 《Physical chemistry chemical physics : PCCP》2012,14(10):3482-3489
Salicylate synthase from Mycobacterium tuberculosis, MbtI, is a highly promiscuous Mg(2+) dependent enzyme with up to four distinct activities detected in vitro: isochorismate synthase (IS), isochorismate pyruvate lyase (IPL), salicylate synthase (SS) and chorismate mutase (CM). In this paper, Molecular Dynamic (MD) simulations employing hybrid quantum mechanics/molecular mechanics (QM/MM) potentials have been carried out to get a detailed knowledge of the IS and the IPL activities at the molecular level. According to our simulations, the architecture of the MbtI active site allows catalyzing the two reactions: the isochorismate formation, by means of a stepwise mechanism, and the salicylate production from isochorismate, that appears to be pericyclic in nature. Findings also explain the role of the magnesium cation and the pH dependence activity experimentally observed in MbtI. Mg(2+) would be polarizing and pre-organizing the substrate and active site, as well as shifting the pK(a) values of key active site residues. 相似文献
964.
Ojo WS Jacob K Despagnet-Ayoub E Muñoz BK Gonell S Vendier L Nguyen VH Etienne M 《Inorganic chemistry》2012,51(5):2893-2901
The synthesis and characterization (mainly by (19)F NMR and X-ray diffraction) of highly fluorinated aryl-4,5,6,7-tetrafluoroindazoles and their corresponding thallium hydrotris(indazolyl)borate complexes are reported [aryl = phenyl, pentafluorophenyl, 3,5-dimethylphenyl, 3,5-bis(trifluoromethyl)phenyl]. Thanks to N-H···N hydrogen bonds, the indazoles crystallize as dimers that pack differently depending on the nature of the aryl group. The thallium hydrotris(indazolyl)borate complexes Tl[Fn-Tp(4Bo,3aryl)] resulting from the reaction of aryl-4,5,6,7-tetrafluoroindazoles [aryl = phenyl, 3,5-dimethylphenyl, 3,5-bis(trifluoromethyl)phenyl] with thallium borohydride adopt overall C(3v) symmetry with the indazolyl groups bound to boron via their N-1 nitrogen in a conventional manner. When the perfluorinated pentaphenyl-4,5,6,7-tetrafluoroindazole is reacted with thallium borohydride, a single regioisomer of C(s) symmetry having one indazolyl ring bound to boron via its N-2 nitrogen, TlHB(3-pentafluorophenyl-4,5,6,7-tetrafluoroindazol-1-yl)(2)(3-pentafluorophenyl-4,5,6,7-tetrafluoroindazol-2-yl) Tl[F27-Tp((4Bo,3C6F5)*)], is obtained for the first time. Surprisingly, the perfluorinated dihydrobis(indazolyl)borate complex Tl[F(18)-Bp(3Bo,3C6F5)], an intermediate on the way to the hydrotris(indazolyl)borate complex, has C(s) symmetry with two indazolyl rings bound to boron via N-2. The distortion of the coordination sphere around Tl and the arrangement of the complexes in the crystal are discussed. 相似文献
965.
Emanuele Pace Giovanni Salmè Sergio Scopetta Alessio Del Dotto Matteo Rinaldi 《Few-Body Systems》2013,54(7-10):1079-1082
The possibility to extract the quark transverse-momentum distributions in the neutron from semi-inclusive deep inelastic electron scattering off polarized 3He is illustrated through an impulse approximation analysis in the Bjorken limit. The generalization of the analysis at finite momentum transfers in a Poincaré covariant framework is outlined. The definition of the light-front spin-dependent spectral function of a J = 1/2 system allows us to show that within the light-front dynamics only three of the six leading twist T-even transverse-momentum distributions are independent. 相似文献
966.
Jorge Francés Sergio Bleda Sergi Gallego Cristian Neipp Andrés Márquez Inmaculada Pascual Augusto Beléndez 《Physics letters. A》2013,377(34-36):2245-2250
A set of simplified and rigorous electromagnetic vector theories is used for analyzing the transmittance characteristics of diffraction phase gratings. The scalar diffraction theory and the effective medium theory are validated with the exact results obtained via the rigorous coupled-wave theory and the finite-difference time-domain method. The effects of surface profile parameters and also the angle of incidence is demonstrated to be a limiting factor in the accuracy of these theories. Therefore, the error of both simplified theories is also analyzed in non-paraxial domain with the intention of establishing a specific range of validity for both simplified theories. 相似文献
967.
Murad Alim Sergio Cecotti Clay Córdova Sam Espahbodi Ashwin Rastogi Cumrun Vafa 《Communications in Mathematical Physics》2013,323(3):1185-1227
We study the BPS spectra of ${\mathcal{N}=2}$ N = 2 complete quantum field theories in four dimensions. For examples that can be described by a pair of M5 branes on a punctured Riemann surface we explain how triangulations of the surface fix a BPS quiver and superpotential for the theory. The BPS spectrum can then be determined by solving the quantum mechanics problem encoded by the quiver. By analyzing the structure of this quantum mechanics we show that all asymptotically free examples, Argyres-Douglas models, and theories defined by punctured spheres and tori have a chamber with finitely many BPS states. In all such cases we determine the spectrum. 相似文献
968.
Sergio Luis Costa Ferreira Maria das Graças Andrade Korn Hadla Sousa Ferreira Erik Galvao Paranhos da Silva Rennan Geovanny Oliveira Araújo Anderson Santos Souza 《应用光谱学评论》2013,48(5):475-491
Abstract The present article describes fundamentals and applications of multivariate techniques used for the optimization of analytical procedures and systems involving spectroanalytical methods such as flame atomic absorption spectrometry (FAAS), electrothermal atomic absorption spectrometry (ETAAS), inductively coupled plasma optical emission spectrometry (ICP OES), and inductively coupled plasma mass spectrometry (ICP‐MS), considering the main steps of a chemical analysis. This way, applications of experimental designs in optimization of sampling systems, digestion procedures, preconcentration procedures, instrumental parameters of quantification steps of analytical methods, and robustness tests have been summarized in this work. 相似文献
969.
The propagation of analyticity for sufficiently smooth solutions to either strictly hyperbolic, or smoothly symmetrizable nonlinear systems, dates back to Lax [14] and Alinhac and Métivier [2]. Here we consider the general case of a system with real, possibly multiple, characteristics, and we ask which regularity should be a priori required of a given solution in order that it enjoys the propagation of analyticity. By using the technique of the quasi-symmetrizer of a hyperbolic matrix, we prove, in the one-dimensional case, the propagation of analyticity for those solutions which are Gevrey functions of order s for some s < m/(m ? 1), m being the maximum multiplicity of the characteristics. 相似文献
970.
Sergio Galván Carlos Rubio Jesús Pacheco Crisanto Mendoza Miguel Toledo 《Journal of Global Optimization》2013,55(1):53-72
In recent years, numerical and experimental investigations on the draft tube performance have confirmed the importance of the inlet swirling flow created by the runner vanes. The results indicate that it is still a challenge to get the optimal flow distribution at the draft tube inlet which gives the best machine performance over a range of operation points. Consequently, there is a need to adjust the runner-draft tube coupling to minimize the losses arising from the inlet flow distribution. This paper focus on establishing an optimization methodology for maximizing the draft tube performance as a function of the inlet velocity profile. The overall work is divides into two parts: The part one establish the inlet velocity parametrization, the numerical optimization set-up and the objective function definition. The part two validate the numerical CFD draft tube model. These steps are represented by the coupling of the commercial softwares MATLAB, FLUENT and iSIGHT. It is considered that this proved methodology will help to find a inlet velocity profile shape which will be able to suppress or mitigate the undesirable draft tube flow characteristics. 相似文献