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91.
Coclite Giuseppe Maria Dipierro Serena Maddalena Francesco Valdinoci Enrico 《Journal of Nonlinear Science》2020,30(4):1285-1305
The formation of singularities in finite time in nonlocal Burgers’ equations, with time-fractional derivative, is studied in detail. The occurrence of finite-time singularity is proved, revealing the underlying mechanism, and precise estimates on the blowup time are provided. The employment of the present equation to model a problem arising in job market is also analyzed.
相似文献92.
Margadonna S Takabayashi Y McDonald MT Kasperkiewicz K Mizuguchi Y Takano Y Fitch AN Suard E Prassides K 《Chemical communications (Cambridge, England)》2008,(43):5607-5609
The newly discovered superconductor FeSe(1-x) (x approximately 0.08, T(c)(onset) approximately 13.5 K at ambient pressure rising to 27 K at 1.48 GPa) exhibits a structural phase transition from tetragonal to orthorhombic below 70 K at ambient pressure-the crystal structure in the superconducting state shows remarkable similarities to that of the REFeAsO(1-x)F(x) (RE = rare earth) superconductors. 相似文献
93.
Rapid microchip-based electrophoretic immunoassays for the detection of swine influenza virus 总被引:1,自引:0,他引:1
Reichmuth DS Wang SK Barrett LM Throckmorton DJ Einfeld W Singh AK 《Lab on a chip》2008,8(8):1319-1324
Towards developing rapid and portable diagnostics for detecting zoonotic diseases, we have developed microchip-based electrophoretic immunoassays for sensitive and rapid detection of viruses. Two types of microchip-based electrophoretic immunoassays were developed. The initial assay used open channel electrophoresis and laser-induced fluorescence detection with a labeled antibody to detect influenza virus. However, this assay did not have adequate sensitivity to detect viruses at relevant concentrations for diagnostic applications. Hence, a novel assay was developed that allows simultaneous concentration and detection of viruses using a microfluidic chip with an integrated nanoporous membrane. The size-exclusion properties of the in situ polymerized polyacrylamide membrane are exploited to simultaneously concentrate viral particles and separate the virus/fluorescent antibody complex from the unbound antibody. The assay is performed in two simple steps--addition of fluorescently labeled antibodies to the sample, followed by concentration of antibody-virus complexes on a porous membrane. Excess antibodies are removed by electrophoresis through the membrane and the complex is then detected downstream of the membrane. This new assay detected inactivated swine influenza virus at a concentration four times lower than that of the open-channel electrophoresis assay. The total assay time, including device regeneration, is six minutes and requires <50 microl of sample. The filtration effect of the polymer membrane eliminates the need for washing, commonly required with surface-based immunoassays, increasing the speed of the assay. This assay is intended to form the core of a portable device for the diagnosis of high-consequence animal pathogens such as foot-and-mouth disease. The electrophoretic immunoassay format is rapid and simple while providing the necessary sensitivity for diagnosis of the illness state. This would allow the development of a portable, cost-effective, on-site diagnostic system for rapid screening of large populations of livestock, including sheep, pigs, cattle, and potentially birds. 相似文献
94.
Garramone G Pietrangeli D Ricciardi G Conoci S Guascito MR Malitesta C Cesari D Casilli S Giotta L Giancane G Valli L 《The journal of physical chemistry. B》2008,112(37):11517-11528
Thin films of a newly synthesized iron(III) porphyrazine, LFeOESPz ( L = ClEtO, OESPz = ethylsulfanylporphyrazine), have been deposited by the Langmuir-Schafer (LS) technique (horizontal lifting) on ITO or gold substrates. Before deposition, the floating films have been investigated at the air-water interface by pressure/area per molecule (pi/ A) experiments, Brewster angle microscopy (BAM) and UV-vis reflection spectroscopy (RefSpec). The complex reacts with water subphase (pH 6.2) forming the mu-oxo dimer, which becomes the predominant component of the LS films ( LS-Fe) as indicated by optical, IR, XPS, and electrochemical data. LS-Fe multilayers exhibit, between open circuit potential (OCP) and +0.90 V (vs SCE), two independent peak pairs with formal potentials, E surf (I) and E surf(II) of +0.56 V and +0.78 V, respectively. According to dynamic voltammetric and coulometric experiments the peak pair at +0.56 V is attributed to one-electron process at the iron(III) centers on the monomer, while the peak pair at +0.78 V is associated to a four-electron process involving mu-oxo-dimer oligomers. LS-Fe films prove to be quite stable electrochemically between OCP and +0.90 V. The electrochemical stability decreases, however, when the potential range is extended both anodically and cathodically outside these limits, due to formation of new species. Upon incubation with TCA solutions, LS-Fe films show remarkable changes in the UV-vis spectra, which are consistent with a significant mu-oxo dimer --> monomer conversion. Addition of TCA to the electrochemical cell using a LS-Fe film as working electrode, results in a linear increase of a cathodic current peak near -0.40 V as the TCA concentration varies in the 0.1-2.0 mM range. This behavior is interpreted in terms of TCA inducing a progressive change in the composition of the LS-Fe films in favor of the monomeric iron(III) porphyrazine, which is responsible for the observed increase in the cathodic current near -0.40 V. 相似文献
95.
Simone Brannetti Serena Gentile Dr. Alejandro Chamorro-Garcia Luca Barbero Dr. Erica Del Grosso Prof. Francesco Ricci 《Angewandte Chemie (International ed. in English)》2023,62(47):e202313243
Here we develop Lateral Flow Assays (LFAs) that employ as functional elements DNA-based structures decorated with reporter tags and recognition elements. We have rationally re-engineered tile-based DNA tubular structures that can act as scaffolds and can be decorated with recognition elements of different nature (i.e. antigens, aptamers or proteins) and with orthogonal fluorescent dyes. As a proof-of-principle we have developed sandwich and competitive multiplex lateral flow platforms for the detection of several targets, ranging from small molecules (digoxigenin, Dig and dinitrophenol, DNP), to antibodies (Anti-Dig, Anti-DNP and Anti-MUC1/EGFR bispecific antibodies) and proteins (thrombin). Coupling the advantages of functional DNA-based scaffolds together with the simplicity of LFAs, our approach offers the opportunity to detect a wide range of targets with nanomolar sensitivity and high specificity. 相似文献
96.
Takabayashi Y McDonald MT Papanikolaou D Margadonna S Wu G Liu RH Chen XH Prassides K 《Journal of the American Chemical Society》2008,130(29):9242-9243
The superconducting transition temperature of the high-Tc SmO1-xFxFeAs superconductors increases monotonically as the F-doping level x increases to 0.20. High-pressure magnetization experiments reveal a strong sensitivity of Tc to interatomic distances in the underdoped regime (x = 0.12) with the pressure coefficient of Tc, d(ln Tc)/dP being strongly positive. However, as the doping level increases further to x = 0.15, we find that this sensitivity is strongly suppressed and at the same time, d(ln Tc)/dP sharply switches over to assume negative values with Tc decreasing with increasing applied pressure. The abrupt change in the pressure response of the superconducting properties of the SmO1-xFxFeAs phases coincides with the putative existence of a quantum critical point (QCP) near x approximately 0.14, as proposed by resistivity and Hall effect measurements. 相似文献
97.
Natalini B Sardella R Macchiarulo A Natalini S Pellicciari R 《Journal of separation science》2007,30(1):21-27
A dynamic coating of the RP-18 carbon chain layers with the new chiral selector (S)-(-)-alpha,alpha-di(2-naphthyl)-2-pyrrolidinemethanol allowed the formation of a mixed chiral stationary phase that has been used in the separation of a selected set of amino acid racemates. Both a representative model and classification structure-property relationship studies have been performed in order to study the contribution of hydrophobic, bulky and electron-donating groups in the side chain of the chiral selector to the mechanism of chiral recognition. 相似文献
98.
Aragoni MC Arca M Devillanova FA Hursthouse MB Huth SL Isaia F Lippolis V Mancini A Soddu S Verani G 《Dalton transactions (Cambridge, England : 2003)》2007,(21):2127-2134
The reaction between the coordinatively unsaturated phosphonodithioato complex [Ni(MeOpdt)2] (1) [MeOpdt = (MeO)(4-MeOC(6)H(4))PS2-] and tptz [2,4,6-tris(2-pyridyl)-1,3,5-triazine] has been investigated. Spectrophotometric and conductometric titrations showed the formation of a neutral and an ionic species, i.e. [Ni(MeOdtp)2(tptz)] (2) and [Ni(tptz)2](MeOdtp)2 (3), in correspondence to 1 : 1 and 2 : 1 tptz : ratios, respectively. XRD studies confirmed the formation of both complexes isolated in the compounds 2.MeOH and 3.4H(2)O. In the neutral complex 2 the central Ni(II) ion features a distorted octahedral coordination, achieved through three N-atoms of tptz and three S-atoms belonging to two MeOpdt anions, one of which unexpectedly acts as a monodentate S-donor. In 3.4H(2)O, the two phosphonodithioato anions are non-coordinating and counterbalance the charge of the [Ni(tptz)2](2+) distorted octahedral complex. From the reaction 2 of with I2 and Br2, crystals of [Ni(tptz)2](I3)2 (5) and [Ni(tptz)Br(micro-Br)]2 (6) have been obtained. The dinuclear complex 6 features a structure showing tubular canals with openings of about 6 x 6 A. 相似文献
99.
100.
Orlandini S Giannini I Gotti R Pinzauti S La Porta E Furlanetto S 《Electrophoresis》2007,28(3):395-405
A fast and selective CZE method for the determination of mizolastine and related impurities is described. Response surface methodology was applied to study the influence of phosphate/triethanolamine (TEA) buffer concentration, heptakis(2,3,6-tri-O-methyl)-beta-CD (TMbetaCD) concentration, voltage and temperature. The optimum conditions were: 105 mM phosphate/TEA buffer (pH 3.0) containing 10 mM TMbetaCD, temperature 19 degrees C and voltage 30 kV. Validation of the method was performed in drug substance and drug product. Robustness was evaluated using a Plackett-Burman design, including pH among the considered factors. Applying the optimal conditions, the nine peaks were baseline separated in about 10 min. The method was applied to the quality control of mizolastine in controlled-release tablets. 相似文献