Synthesis and Characterization of New Phthalocyanines Peripherally Fused to Four 21-Membered Dithiacrown Ether Macrocycles

Summary. A novel metal-free phthalocyanine and its nickel(II) and copper(II) phthalocyaninato complexes were prepared. The new compounds were characterized by elemental analyses, ¹H- and ¹³C-NMR, IR, UV-Vis, and mass spectral data. The NMR and/or UV-Vis spectra of these compounds showed extremely broad bands and/or peaks. This phenomenon seems to be related to the presence of the sulfur substituents, which is consistent with the data observed for similar compounds. The absorption spectra of these compounds were greatly affected by aggregation processes. Corresponding author. E-mail: dismail@ktu.edu.tr Received July 24, 2002; accepted August 2, 2002 Published online April 7, 2003     

Synthesis of Two Alnustone-Like Natural Diarylheptanoids via 4 + 3 Strategy

The first total synthesis of (4E,6E)-1,7-bis(3,4-dihydroxyphenyl)-hepta-4,6-dien-3-one and an alternative synthesis of (4E,6E)-1,7-bis(4-hydroxyphenyl)-hepta-4,6-dien-3-one, two natural diarylheptanoids, mainly based on Claisen–Schmidt condensation were described. The crucial steps of the syntheses were the condensation of OH-protected 4-aryl-2-butanones with OH-protected 3-aryl-acrylaldehydes by the in situ enamination and then deprotection of OH groups to give the corresponding natural diarylheptanoids.     

Complete monotonicity results for some functions involving the gamma and polygamma functions

In this paper we prove new complete monotonicity properties of some functions involving the gamma function. As consequences of them we establish various new upper and lower bounds for the gamma function and the harmonic numbers.     

A modulus gradient model for an axially loaded inhomogeneous elastic rod

A new gradient elasticity formulation is proposed for a one-dimensional linear elastic inhomogeneous rod. In the new formulation, similar to the differential relation between the local strain and the gradient enhanced strain in the classical models of gradient elasticity, a differential relation is proposed for the Young’s modulus. Analytical and finite element solutions of the proposed formulation are derived. Results of the proposed model are compared with a classical model of gradient elasticity for a model problem of carbon nanotube reinforced polymer composite.     

An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT<Subscript>1</Subscript> Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies

A new 1,5 disubstituted imidazole AT₁ Angiotensin II (AII) receptor antagonist related to losartan with reversion of butyl and hydroxymethyl groups at the 2-, 5-positions of the imidazole ring was synthesized and evaluated for its antagonist activity (V8). In vitro results indicated that the reorientation of butyl and hydroxymethyl groups on the imidazole template of losartan retained high binding affinity to the AT₁ receptor concluding that the spacing of the substituents at the 2,5- positions is of primary importance. The docking studies are confirmed by binding assay results which clearly show a comparable binding score of the designed compound V8 with that of the prototype losartan. An efficient, regioselective and cost effective synthesis renders the new compound as an attractive candidate for advanced toxicological evaluation and a drug against hypertension.     

Nanostructure‐Directed Physisorption vs Chemisorption at Semiconductor Interfaces: The Inverse of the HSAB Concept

A concept, complementary to that of hard and soft acid–base interactions (HSAB‐dominant chemisorption) and consistent with dominant physisorption to a semiconductor interface, is presented. We create a matrix of sensitivities and interactions with several basic gases. The concept, based on the reversible interaction of hard‐acid surfaces with soft bases, hard‐base surfaces with soft acids, or vice versa, corresponds 1) to the inverse of the HSAB concept and 2) to the selection of a combination of semiconductor interface and analyte materials, which can be used to direct a physisorbed vs chemisorbed interaction. The technology, implemented on nanopore coated porous silicon micropores, results in the coupling of acid–base chemistry with the depletion or enhancement of majority carriers in an extrinsic semiconductor. Using the inverse‐HSAB (IHSAB) concept, significant and predictable changes in interface sensitivity for a variety of gases can be implemented. Nanostructured metal oxide particle depositions provide selectivity and complement a highly efficient electrical contact to a porous silicon nanopore covered microporous interface. The application of small quantities (much less than a monolayer) of nanostructured metals, metal oxides, and catalysts which focus the physisorbtive and chemisorbtive interactions of the interface, can be made to create a range of notably higher sensitivities for reversible physisorption. This is exemplified by an approach to reversible, sensitive, and selective interface responses. Nanostructured metal oxides developed from electroless gold (Au_xO), tin (SnO₂), copper (Cu_xO), and nickel (NiO) depositions, nanoalumina, and nanotitania are used to demonstrate the IHSAB concept and provide for the detection of gases, including NH₃, PH₃, CO, NO, and H₂S, in an array‐based format to the sub‐ppm level.     

Gamow-Teller 1<Superscript>+</Superscript> states in <Superscript>112–124</Superscript>Sb isotopes

The violated supersymmetry property of the pairing interaction between nucleons were restored using the Pyatov method [Pyatov and Salamov, Nucleonica 22, 127 (1977)]. The eigenvalues and eigenfunctions of the restored Hamiltonian with the separable residual Gamow-Teller effective interactions in the particle-hole and particle-particle channels were solved within the framework of proton-neutron quasirandom phase approximation (pnQRPA). The Gamow-Teller resonance energies for ^112–124Sb isotopes and the differential cross-sections for Sn(³He, t)Sb reactions at E(³He) = 200 MeV occurring by the excitation of the Gamow-Teller resonance state were calculated. The calculated values were compared with other calculations and the corresponding experimental data.