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81.
Rendle PM Seger A Rodrigues J Oldham NJ Bott RR Jones JB Cowan MM Davis BG 《Journal of the American Chemical Society》2004,126(15):4750-4751
The continuing ability of bacteria to resist current antibiotic treatments highlights the need for alternative strategies for inhibiting their pathogenicity. Bacterial attachment is a major factor in infectivity and virulence. This key binding phase of bacteria to any potential host is mediated by adhesin proteins and so these present an attractive therapeutic target for antiinfective blocking strategies. However, the natural ligands to adhesins are large, typically complex molecules that are difficult to mimic with small molecules. We describe here a method that creates precise synthetic mimics of glycoproteins that are designed to bind adhesins. By using protein-degrading enzymes as the basis for these mimics we have created large-molecule protein ligands that inhibit aggregation of pathogenic bacteria at levels greater than a million-fold higher than small-molecule inhibitors of adhesins. 相似文献
82.
Christoph Seger Thomas Pacher Harald Greger Ekarin Saifah Otmar Hofer 《Monatshefte für Chemie / Chemical Monthly》2002,133(1):97-100
Summary. The bisamide aglairubine was isolated from different Aglaia species. The original structure was revised on the basis of FDMS and 2D-NMR data. Since all isolates were obtained from species
belonging to the section Amoora of the genus Aglaia, aglairubine might serve as a taxonomic marker.
Received July 3, 2001. Accepted July 12, 2001 相似文献
83.
Measurements of the absorption coefficient and the refractive index of crystalline lithium fluoride have been carried out in the infrared region between 300 and 900 microns wavelength. The spectrometer which has been used was of the periodic interference-modulator type. Some general properties of this instrument are described. 相似文献
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86.
Niels Meiser Kai Seger Valdas Pasiskevicius Andrius Zukauskas Carlota Canalias Fredrik Laurell 《Applied physics. B, Lasers and optics》2014,116(2):493-499
Self-starting and stable mode-locking of an Yb:KYW laser in the picoseconds pulse regime has been achieved by exploiting a positive cascaded Kerr lens in periodically poled KTP. The use of a volume Bragg grating (VBG), for locking the output spectrum of the laser, was essential to achieve a stable mode-locked operation in this wide gain bandwidth laser material. The laser emitted stable, nearly transform-limited pulses with a duration of 16 ps, at a repetition rate of 210 MHz, and with an energy of 3.2 nJ. The mode-locked spectrum was centred at 1,029.1 nm and featured a FWHM bandwidth of 85 pm, which was effectively determined by the VBG. Combination of a large cascaded Kerr nonlinearity with spectral limiting by a VBG represents so far the best opportunity for stable mode-locking of a broadband laser to produce near-transform-limited picosecond pulses. 相似文献
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