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61.
Schroeder M Hogwood J Gray E Mulloy B Hackett AM Johansen KB 《Analytical and bioanalytical chemistry》2011,399(2):763-771
Protamine sulphate is an effective inhibitor of heparin and is used clinically to neutralise both low molecular weight heparins
(LMWH) and unfractionated heparin (UFH). However, protamine sulphate does not fully counter the anti-Xa effect of LMWH, even
in excess (>40 μg to 1 IU/ml). To investigate the molecular basis for this observation, the residual potencies in the presence
and absence of plasma as well as the molecular weight profiles of commercial LMWH neutralised with increasing amounts of protamine
were measured. Materials over 5000 Da are preferentially neutralised by protamine. To further investigate this molecular weight
dependence, monodisperse oligosaccharides were prepared from three commercial LMWHs. The specific anti-Xa activity for the
fractions increased with molecular weight, and was found to vary between the three preparations for oligosaccharides of the
same molecular weight. Our results indicate that protamine sulphate neutralisation is largely dependent on molecular weight,
leading to the implication that LMWHs containing a larger proportion of small oligosaccharides will not be as effectively
neutralised. Protamine sulphate neutralisation of any given LMWH is also affected by the specific anticoagulant activities
of its low molecular weight components, which varies between LMWH products, presumably with the method of manufacture. 相似文献
62.
N. Ahmad C. Nanjundayya W. G. Chace M. A. Ssobolew M. M. Tschilikin A. T. Iwanowa F. Kalmanowitsch A. Kolotyrewa C. F. Cross E. J. Bevan A. Eavenson J. W. Creely J. H. Skinkle O. Viertel A. J. Hall W. N. Udalskaja D. A. Clibbens A. H. Little Karin Schulze S. M. Edelstein E. Lindemann F. Schütz W. Klauditz P. Winterfeld F. H. Guernsay L. T. Howells F. Schroeder R. Finlay G. Hasse Niederhauser H. Ris R. D. Nutting W. Lesnianski F. Fabrowicz und Coch 《Fresenius' Journal of Analytical Chemistry》1938,115(1-2):51-57
Ohne Zusammenfassung 相似文献
63.
64.
E. Carriére R. Liauté P. F. Nichols H. M. Reed J. S. Mitchell G. A. Pitman B. I. Leonow und W. C. Schroeder 《Fresenius' Journal of Analytical Chemistry》1934,98(7-8):280-283
Ohne Zusammenfassung 相似文献
65.
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67.
Udo Feldkamp Ron Wacker Hendrik Schroeder Wolfgang Banzhaf Christof M Niemeyer 《Chemphyschem》2004,5(3):367-372
We report on the microarray-based in vitro evaluation of two libraries of DNA oligonucleotide sequences, designed in silico for applications in supramolecular self-assembly, such as DNA computing and DNA-based nanosciences. In this first study which is devoted to the comparison of sequence motif properties theoretically predicted with their performance in real-life, the DNA-directed immobilization (DDI) of proteins was used as an example of DNA-based self-assembly. Since DDI technologies, DNA computing, and DNA nanoconstruction essentially depend on similar prereguisites, in particular, large and uniform hybridization efficiencies combined with low nonspecific cross-reactivity between individual sequences, we anticipate that the microarray approach demonstrated here will enable rapid evaluation of other DNA sequence libraries. 相似文献
68.
Möbius structure (on a set \(X\) ) is a class of metrics having the same cross-ratios. A Möbius structure is Ptolemaic if it is invariant under inversion operations. The boundary at infinity of a \(\mathrm{CAT }(-1)\) space is in a natural way a Möbius space, which is Ptolemaic. We give a free of classification proof of the following result that characterizes the rank one symmetric spaces of noncompact type purely in terms of their Möbius geometry: Let \(X\) be a compact Ptolemy space which contains a Ptolemy circle and allows many space inversions. Then \(X\) is Möbius equivalent to the boundary at infinity of a rank one symmetric space. 相似文献
69.
Aubert B Bona M Boutigny D Karyotakis Y Lees JP Poireau V Prudent X Tisserand V Zghiche A Garra Tico J Grauges E Lopez L Palano A Eigen G Stugu B Sun L Abrams GS Battaglia M Brown DN Button-Shafer J Cahn RN Groysman Y Jacobsen RG Kadyk JA Kerth LT Kolomensky YG Kukartsev G Lopes Pegna D Lynch G Mir LM Orimoto TJ Ronan MT Tackmann K Wenzel WA del Amo Sanchez P Hawkes CM Watson AT Held T Koch H Lewandowski B Pelizaeus M Schroeder T Steinke M Walker D Asgeirsson DJ Cuhadar-Donszelmann T Fulsom BG 《Physical review letters》2007,99(20):201802
We perform an amplitude analysis of B+/--->phi(1020)K*(892)+/- decay with a sample of about 384 x 10(6) BB[over ] pairs recorded with the BABAR detector. Overall, twelve parameters are measured, including the fractions of longitudinal fL and parity-odd transverse f perpendicular amplitudes, branching fraction, strong phases, and six parameters sensitive to CP violation. We use the dependence on the Kpi invariant mass of the interference between the JP=1(-) and 0+ Kpi components to resolve the discrete ambiguity in the determination of the strong and weak phases. Our measurements of fL=0.49+/-0.05+/-0.03, f perpendicular=0.21+/-0.05+/-0.02, and the strong phases point to the presence of a substantial helicity-plus amplitude from a presently unknown source. 相似文献
70.
del Amo Sanchez P Lees JP Poireau V Prencipe E Tisserand V Garra Tico J Grauges E Martinelli M Palano A Pappagallo M Eigen G Stugu B Sun L Battaglia M Brown DN Hooberman B Kerth LT Kolomensky YG Lynch G Osipenkov IL Tanabe T Hawkes CM Watson AT Koch H Schroeder T Asgeirsson DJ Hearty C Mattison TS McKenna JA Khan A Randle-Conde A Blinov VE Buzykaev AR Druzhinin VP Golubev VB Onuchin AP Serednyakov SI Skovpen YI Solodov EP Todyshev KY Yushkov AN Bondioli M Curry S Kirkby D Lankford AJ 《Physical review letters》2010,105(17):172001
We present a search for f(J)(2220) production in radiative J/ψ→γf(J)(2220) decays using 460 fb?1 of data collected with the BABAR detector at the SLAC PEP-II e(+)e? collider. The f(J)(2220) is searched for in the decays to K(+)K? and K(S)?K(S)?. No evidence of this resonance is observed, and 90% confidence level upper limits on the product of the branching fractions for J/ψ→γf(J)(2220) and f(J)(2220)→K(+)K?(K(S)?K(S)?) as a function of spin and helicity are set at the level of 10??, below the central values reported by the Mark III experiment. 相似文献