全文获取类型
收费全文 | 223篇 |
免费 | 6篇 |
专业分类
化学 | 164篇 |
力学 | 5篇 |
数学 | 7篇 |
物理学 | 53篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 6篇 |
2018年 | 2篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 9篇 |
2013年 | 12篇 |
2012年 | 13篇 |
2011年 | 18篇 |
2010年 | 5篇 |
2009年 | 6篇 |
2008年 | 14篇 |
2007年 | 19篇 |
2006年 | 19篇 |
2005年 | 20篇 |
2004年 | 10篇 |
2003年 | 6篇 |
2002年 | 11篇 |
2001年 | 4篇 |
2000年 | 3篇 |
1999年 | 4篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1993年 | 6篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1989年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1937年 | 2篇 |
1936年 | 1篇 |
1935年 | 1篇 |
1925年 | 1篇 |
排序方式: 共有229条查询结果,搜索用时 31 毫秒
91.
Thalhammer A Mecinović J Loenarz C Tumber A Rose NR Heightman TD Schofield CJ 《Organic & biomolecular chemistry》2011,9(1):127-135
Based on structural analysis of the human 2-oxoglutarate (2OG) dependent JMJD2 histone N(ε)-methyl lysyl demethylase family, 3-substituted pyridine 2,4-dicarboxylic acids were identified as potential inhibitors with possible selectivity over other human 2OG oxygenases. Microwave-assisted palladium-catalysed cross coupling methodology was developed to install a diverse set of substituents on the sterically demanding C-3 position of a pyridine 2,4-dicarboxylate scaffold. The subsequently prepared di-acids were tested for in vitro inhibition of the histone demethylase JMJD2E and another human 2OG oxygenase, prolyl-hydroxylase domain isoform 2 (PHD2, EGLN1). A subset of substitution patterns yielded inhibitors with selectivity for JMJD2E over PHD2, demonstrating that structure-based inhibitor design can enable selective inhibition of histone demethylases over related human 2OG oxygenases. 相似文献
92.
93.
The effect of a high Reynold's number, pressure-driven flow of a compressible gas on the conformation of an oligomer tethered to the wall of a square channel is studied under both ideal solvent and poor solvent conditions using a hybrid multiparticle collision dynamics and molecular dynamics algorithm. Unlike previous studies, the flow field contains an elongational component in addition to a shear component as well as fluid slip near the walls and results in a Schmidt number for the polymer beads that is less than unity. In both solvent regimes the oligomer is found to extend in the direction of flow. Under the ideal solvent conditions, torsional twisting of the chain and aperiodic cyclical dynamics are observed for the end of the oligomer. Under poor solvent conditions, a metastable helix forms in the end of the chain despite the lack of any attractive potential between beads in the oligomeric chain. The formation of the helix is postulated to be the result of a solvent induced chain collapse that has been confined to a single dimension by a strong flow field. 相似文献
94.
The Harary‐Ross clique detection algorithm has often been neglected in analyses of symmetric graphs and tolerance relations because of presumed storage and computation problems. This paper presents a modification of the original algorithm which overcomes these difficulties. The modified algorithm is shown to perform as well as other recent structurally different algorithms. Indeed, for arc densities which might be expected in typical sociometric analyses, the modified algorithm has certain conceptual and operational advantages. The paper also indicates possible applications of the algorithm in the analysis of non‐symmetric functional relations and points out the conceptual similarity with simplicial connectivity analysis. 相似文献
95.
Hamed RB Henry L Gomez-Castellanos JR Mecinović J Ducho C Sorensen JL Claridge TD Schofield CJ 《Journal of the American Chemical Society》2012,134(1):471-479
The biocatalytic versatility of wildtype and engineered carboxymethylproline synthases (CMPSs) is demonstrated by the preparation of functionalized 5-carboxymethylproline derivatives methylated at C-2, C-3, C-4, or C-5 of the proline ring from appropriately substituted amino acid aldehydes and malonyl-coenzyme A. Notably, compounds with a quaternary center (at C-2 or C-5) were prepared in a stereoselective fashion by engineered CMPSs. The substituted-5-carboxymethyl-prolines were converted into the corresponding bicyclic β-lactams using a carbapenam synthetase. The results demonstrate the utility of the crotonase superfamily enzymes for stereoselective biocatalysis, the amenability of carbapenem biosynthesis pathways to engineering for the production of new bicyclic β-lactam derivatives, and the potential of engineered biocatalysts for the production of quaternary centers. 相似文献
96.
The drying dynamics in three dimensional porous media are studied with confocal microscopy. We observe abrupt air invasions in size from single particle to hundreds of particles. We show that these result from the strong flow from menisci in large pores to menisci in small pores during drying. This flow causes air invasions to start in large menisci and subsequently spread throughout the entire system. We measure the size and structure of the air invasions and show that they are in accord with invasion percolation. By varying the particle size and contact angle we unambiguously demonstrate that capillary pressure dominates the drying process. 相似文献
97.
Peter Jackson Geoffrey Dent David Carter Deborah J. Schofield John M. Chalmers Tom Visser Marjo Vredenbregt 《Journal of separation science》1993,16(9):515-521
As part of a detailed investigation into the application of GC-FTIR in industrial and environmental analysis, representative sets of samples have been analyzed in parallel using commercial high-sensitivity instruments. Two of the instruments utilize low temperature storage of the GC eluate to extend the time available for FTIR analysis, yielding greater sensitivity than that possible by conventional ‘light-pipe’ GC-FTIR. In certain circumstances, instruments using both types of sample storage give rise to spectra exhibiting features characteristic of the interface used. Chromatographic resolution was found not to be significantly degraded by use of either sample storage interface. Particular advantages were found in having parallel flame ionization detection and mass spectrometry; this enabled the location of smaller components and gave greater certainty of identification. 相似文献
98.
M. Andrew I.M.V. Burholt N.J. Kernoghan T.P. Lynch R. Mackison D. Mealor J.A. Price P. Schofield 《Journal of chromatography. A》1993,640(1-2):111-125
A method for elemental analysis that employs a novel coupled combustion—ion chromatography (C---IC) apparatus is described in detail. The samples are combusted and the products collected in a dilute peroxide solution. This solution is loaded onto a concentrator column which is then introduced into the injection position of a suppressed conductivity anion chromatography system. The method is rapid, reliable, free from interferences and has the capacity for simultaneous determination of sulphur and chlorine in organic liquids at concentrations down to 0.03 mg/1. Provided that the capacity of the concentrator column is not exceeded, the recovery for organic standards of both chlorine and sulphur in a variety of organic solvents is greater than 93%, irrespective of the solvent and the sample volume and concentration. Repeatability is only slightly worse than that observed for conventional direct IC analysis of aqueous solutions. At concentrations of 0.4 mg/1 C1 and 0.5 mg/1 S, the % standard deviations (n = 10) were found to be 2.9 and 3.5% respectively. The results obtained with the C---IC analyser for both standards and petroleum-based samples are in good agreement with those obtained by microcoulometry. 相似文献
99.
The theoretical framework for higher-order correlation functions involving multiple times and multiple points in a classical, many-body system developed by Van Zon and Schofield [Phys. Rev. E 2002, 65, 011106] is extended here to include tagged particle densities. Such densities have found an intriguing application as proposed measures of dynamical heterogeneities in structural glasses. The theoretical formalism is based upon projection operator techniques which are used to isolate the slow time evolution of dynamical variables by expanding the slowly evolving component of arbitrary variables in an infinite basis composed of the products of slow variables of the system. The resulting formally exact mode-coupling expressions for multiple-point and multiple-time correlation functions are made tractable by applying the so-called N-ordering method. This theory is used to derive for moderate densities the leading mode coupling expressions for indicators of relaxation type and domain relaxation, which use dynamical filters that lead to multiple-time correlations of a tagged particle density. The mode coupling expressions for higher order correlation functions are also successfully tested against simulations of a hard sphere fluid at relatively low density. 相似文献
100.
Cation–π Interactions Contribute to Substrate Recognition in γ‐Butyrobetaine Hydroxylase Catalysis
下载免费PDF全文
![点击此处可从《Chemistry (Weinheim an der Bergstrasse, Germany)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Jos J. A. G. Kamps Amjad Khan Dr. Hwanho Choi Robert K. Lesniak Dr. Jürgen Brem Dr. Anna M. Rydzik Dr. Michael A. McDonough Prof. Christopher J. Schofield Prof. Timothy D. W. Claridge Dr. Jasmin Mecinović 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(4):1270-1276
γ‐Butyrobetaine hydroxylase (BBOX) is a non‐heme FeII‐ and 2‐oxoglutarate‐dependent oxygenase that catalyzes the stereoselective hydroxylation of an unactivated C?H bond of γ‐butyrobetaine (γBB) in the final step of carnitine biosynthesis. BBOX contains an aromatic cage for the recognition of the positively charged trimethylammonium group of the γBB substrate. Enzyme binding and kinetic analyses on substrate analogues with P and As substituting for N in the trimethylammonium group show that the analogues are good BBOX substrates, which follow the efficiency trend N+>P+>As+. The results reveal that an uncharged carbon analogue of γBB is not a BBOX substrate, thus highlighting the importance of the energetically favorable cation–π interactions in productive substrate recognition. 相似文献