Polyphenolics with Strong Antioxidant Activity from Acacia nilotica Ameliorate Some Biochemical Signs of Arsenic-Induced Neurotoxicity and Oxidative Stress in Mice

Neurotoxicity is a serious health problem of patients chronically exposed to arsenic. There is no specific treatment of this problem. Oxidative stress has been implicated in the pathological process of neurotoxicity. Polyphenolics have proven antioxidant activity, thereby offering protection against oxidative stress. In this study, we have isolated the polyphenolics from Acacia nilotica and investigated its effect against arsenic-induced neurotoxicity and oxidative stress in mice. Acacia nilotica polyphenolics prepared from column chromatography of the crude methanol extract using diaion resin contained a phenolic content of 452.185 ± 7.879 mg gallic acid equivalent/gm of sample and flavonoid content of 200.075 ± 0.755 mg catechin equivalent/gm of sample. The polyphenolics exhibited potent antioxidant activity with respect to free radical scavenging ability, total antioxidant activity and inhibition of lipid peroxidation. Administration of arsenic in mice showed a reduction of acetylcholinesterase activity in the brain which was counteracted by Acacia nilotica polyphenolics. Similarly, elevation of lipid peroxidation and depletion of glutathione in the brain of mice was effectively restored to normal level by Acacia nilotica polyphenolics. Gallic acid methyl ester, catechin and catechin-7-gallate were identified in the polyphenolics as the major active compounds. These results suggest that Acacia nilotica polyphenolics due to its strong antioxidant potential might be effective in the management of arsenic induced neurotoxicity.     

Transfer measurements for the Ti+Ni systems at near barrier energies

Large enhancements have been observed in the sub-barrier fusion cross sections for Ti+Ni systems in our previous studies. Coupled channel calculations incorporating couplings to 2⁺ and 3⁻ states failed to explain these enhancements completely. A possibilty of transfer channels contributing to the residual enhancements had been suggested. In order to investigate the role of relevant transfer channels, measurements of one- and two-nucleon transfer were carried out for ^46,48Ti+⁶¹Ni systems. The present paper gives the results of these studies.     

Neue Erzeugungen der Minimalflächen von G. Thomsen

Ohne ZusammenfassungHerrn Josef L. Krames zum 75. Geburtstag am 7. Oktober 1972 gewidmet     

Die Ennepersche Minimalfläche als Grenzfall der Minimalfläche von G. Thomsen

Ohne Zusammenfassung     

Übertragung des Kreisproblems auf reell-quadratische Zahlkörper

Ohne ZusammenfassungDiese Arbeit wurde von der Mathematisch-Naturwissenschaftlichen Fakultät der Georg-August-Universität zu Göttingen als Dissertation angenommen. Herrn Prof. Dr.C. L. Siegel, der die Arbeit anregte, bin ich zu großem Dank verpflichtet. Auch Herrn Prof. Dr.H.-E. Richert danke ich für Ratschläge und Hinweise.     

Fragmentation sous Impact Electronique du Phényl-2 Oxétanne

The mass spectral fragmentation processes of 2-phenyloxetane have been studied by means of isotopic labelling. The origin of the benzoyl ion, which is the base peak, is discused     

The effects of solvation upon the acidities of nitroaromatics

Specific solvation of nitrated phenoxide, anilide and benzyl anions is shown to decrease in that order, with concomitant increases in substituent salvation assisted resonance effects — the nitrobenzyl anions are suggested to be essentially charge-delocalized.