排序方式: 共有179条查询结果,搜索用时 15 毫秒
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Yushi Futamura Makoto Kawatani Sayaka Kazami Kenichi Tanaka Makoto Muroi Takeshi Shimizu Koji Tomita Nobumoto Watanabe Hiroyuki Osada 《Chemistry & biology》2012,19(12):1620-1630
Highlights? Development of an encyclopedia of cell morphology, Morphobase ? Small molecules classified by mode of action with Morphobase ? Morphobase system rapidly predicts molecular targets of compounds ? NPD6689 targets tubulin and is a lead for a class of antitubulin drugs 相似文献
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Atsushi Shoji Erika Sugimoto Sayaka Orita Keiichiro Nozawa Akio Yanagida Yoichi Shibusawa Masao Sugawara 《Analytical and bioanalytical chemistry》2010,397(3):1377-1381
We describe a reusable liposome array based on the formation of cleavable disulfide cross-links between liposomes and the
surface of a glass slip. The N-succinimidyl 3-(2-pyridyldithio)-propionate (SPDP)-modified liposomes encapsulating a pH-sensitive fluorescence dye were
immobilized on a 3-mercaptopropyltrimethoxysilane (MTS)-modified glass slip through the formation of disulfide bonds. The
regeneration of a used slip was performed by the lysis of immobilized liposomes with Triton X-100 and the cleavage of disulfide
bonds by reduction with TCEP, followed by immobilization of SPDP-modified liposomes. The regeneration steps did not affect
the fluorescence intensity of re-immobilized liposomes. The liposome array was applied to simultaneous quantification of growth
hormone related peptides, i.e., GHRF and somatostatin, in a mixture. After optimizing the assay condition, the method allowed
quantification of GHRF and somatostatin in concentration ranges from 0.5 × 10−9 to 0.5 × 10−7 g/mL with detection limits of 2 × 10−10 and 3 × 10−10 g/mL, respectively. 相似文献
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Shinji Nishikawa Sayaka Kami Nurul Ashikin Badrul Haswan Takahiro Uno Takahito Itoh Masataka Kubo 《Journal of polymer science. Part A, Polymer chemistry》2015,53(5):622-628
Polyfluorenes with pendant allyl groups were prepared by terpolymerization of 9,9‐dihexylfluorene‐2,7‐bis(trimethyleneborate), 2,7‐dibromo‐9,9‐bis(2‐allyloxyethyl)fluorene, and 4,7‐dibromo‐2,1,3‐benzothiazole, or 4,7‐dibromo‐2,1,3‐naphthoselenadiazole using Suzuki coupling reaction. The subsequent hydrosilylation reaction of these precursor polymers with ethoxydimethylsilane quantitatively converted the allyl groups to ethoxysilyl groups. Hybridization of the emitting polyfluorenes with silicone was successfully achieved by the solvent‐free sol–gel reaction of tetraethoxysilane and silanol‐terminated polydimethylsiloxane in the presence of the ethoxysilyl‐functionalized polyfluorenes. Fluorescence spectra of these luminescent silicones revealed that emitting polyfluorenes were dispersed homogeneously in the matrix of silicone without aggregation. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53, 622–628 相似文献
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Ishida Y Sakata H Achalkumar AS Yamada K Matsuoka Y Iwahashi N Amano S Saigo K 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(52):14752-14762
Cross-linked polymers prepared by the in-situ polymerization of liquid-crystalline salts were found to work as solid-state hosts with a flexible framework. As a component of such hosts, four kinds of polymerizable amphiphilic carboxylic acids bearing alkyl chains with acryloyloxy (A), dienyl (D), and/or nonreactive (N) chain ends (monomeric carboxylic acids; M(AAA), M(ANA), M(DDD), and M(DND)) were used. The carboxylic acids were mixed with an equimolar amount of a template unit, (1R,2S)-norephedrine (guest amine; G(RS)), to form the corresponding salts. Every salt exhibited a rectangular columnar LC phase at room temperature, which was successfully polymerized by (60)Co γ-ray-induced polymerization without serious structural disordering to afford the salt of cross-linked carboxylic acid (polymeric carboxylic acid; P(AAA), P(ANA), P(DDD), and P(DND)) with G(RS) . Owing to the noncovalency of the interactions between the polymer framework P and the template G(RS), the cross-linked polymers could reversibly release and capture a meaningful amount of G(RS). In response to the desorption and adsorption of G(RS), the cross-linked polymers dramatically switched their nanoscale structural order. A systematic comparison of the polymers revealed that the choice of polymerizable groups has a significant influence on the properties of the resultant polymer frameworks as solid-state hosts. Among these polymers, P(DDD) was found to be an excellent solid-state host, in terms of guest-releasing/capturing ability, guest-recognition ability, durability to repetitive usage, and unique structural switching mode. 相似文献
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The helical tetranuclear complex [LZn(3)La(OAc)(3)] having two benzocrown moieties was designed and synthesized as a novel molecular leverage for helicity control and helix inversion. Short alkanediammonium guests H(3)N(+)(CH(2))(n)NH(3)(+) (n = 4, 6, 8) preferentially stabilized the P-helical isomer of [LZn(3)La(OAc)(3)], while the longer guest H(3)N(+)(CH(2))(12)NH(3)(+) caused a helix inversion to give the M-helical isomer as the major isomer. The differences in the molecular lengths were efficiently translated into helical handedness via the novel molecular leverage mechanism using the gauche/anti conversion of the trans-1,2-disubstituted ethylenediamine unit. 相似文献