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151.
Some mixed ligand complexes of the type [M(L)(en or phen)(X)2]; where M = Mn(II), Co(II) or Ni(II); L = 2-phenyl-3-(benzylamino)-1,2-dihydroquinazolin-4(3H)-one; en = ethylenediamine, phen = 1,10-phenanthroline; X = N3
− or NCS− have been prepared. All the complexes were characterized by physico-chemical, spectroscopic and thermal studies. On the basis
of electronic spectra and magnetic susceptibility measurements, an octahedral geometry has been proposed for all the complexes.
The phen complexes are thermally more stable than the en complexes. The electrochemical behavior of the Ni(II) complexes showed that the complexes of phen are reduced at more positive potential compared to the corresponding en complexes. 相似文献
152.
The temperature autostabilizing nonlinear dielectric element (TANDEL) effect and second harmonic generation have been studied
in the ferroelectric solid solutions of (Pb
x
-Ba1−x
)TiO3 and (Pb
x
-Sr1−x
)TiO3 near the Curie temperature used as TANDEL. The generated second harmonics are linear for low d.c. biasing fields with zero
off-set while they decrease sharply at higher d.c. biasing fields. The results show that these solid solutions might be used
as TANDEL elements. 相似文献
153.
An Efficient Synthesis of 4‐Arylmethylidene‐3‐substituted‐Isoxazol‐5(4H)‐ones in Aqueous Medium
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Abhijit P. Chavan Avinash B. Pinjari Pravin C. Mhaske 《Journal of heterocyclic chemistry》2015,52(6):1911-1915
A series of 4‐arylmethylidene‐3‐substituted‐isoxazol‐5(4H)‐ones were efficiently synthesized by eco‐benign, one pot uncatalyzed reaction of β‐keto‐ester, hydroxylamine hydrochloride, and aromatic aldehyde with electron donating substituent in water. 相似文献
154.
Parthraj Kshirsagar Jaykumar Chavan Mansingraj Nimbalkar Shrirang Yadav Ghansham Dixit 《Natural product research》2015,29(8):780-784
Swertia chirayita is one of the potential medicinal plants of the family Gentianaceae in traditional medicine. Due to its high demand and scarcity, trade of chirayita is affected by adulterants. Swertia species from Western Ghats were compared with S. chirayita for phytochemical characterisation and antioxidant activities by using different extracts. This study revealed that acetone is the best extraction solvent of phenolic and flavonoid compounds with antioxidant properties as compared with other extracts. S. chirayita showed better antioxidant activity than other species with highest content of phenolics and flavonoids. Among the species from Western Ghats, Swertia minor has better antioxidant properties with higher content of phenolics and flavonoids when compared with S. chirayita. Gallic acid was detected in all species under study by using HPLC analysis. The Swertia species under study showed similar phytochemical properties and antioxidant potential and hence their use as substitute to S. chirayita needs to be further investigated. 相似文献
155.
A novel and highly enantioselective method for the synthesis of gamma-amino-alpha,beta-unsaturated esters via tandem alpha-amination-Horner-Wadsworth-Emmons (HWE) olefination of aldehydes is described. The one-pot assembly has been demonstrated for the construction of functionalized chiral 2-pyrrolidones, subunits present in several alkaloids. [structure: see text] 相似文献
156.
In this study, we have focused on the implication of a multiscreening approach in the evaluation of Pseudomonas aeruginosa deacetylase LpxC inhibitory activity of dual PDE4-TNFalpha inhibitors. A genetic function approximation (GFA) directed quantitative structure-activity relationship (QSAR) model was developed for LpxC inhibition on the basis of reported biological activity (Kline and Andersen, J. Med. Chem. 2002, 45, 3112-3129). Subsequently, reported PDE4-TNFalpha inhibitors (Klienman and Campbell, J. Med. Chem. 1998, 41, 266-270) were screened using the QSAR model. Whereby, the compounds were predicted to have equipotent activity with the most potent compound in reported LpxC inhibitor series. A docking analysis of these compounds carried out on the LpxC homology model corroborated the initial results. The compounds were then validated using surface electronic properties analysis and subjected to an adsorption, distribution, metabolism, excretion, and toxicity filter. Taken together, a multiscreening strategy was used to validate potential leads for LpxC inhibition. 相似文献
157.
CuII/RuII and CdII/RuII hybrid complexes [Cu(L1–3)(NC5H4C≡CRu(dppe)2Cl)] (1a-3a) and [Cd(L1-3)(NC5H4C≡CRu(dppe)2Cl)] (1b–3b) have been prepared by reaction of trans-[RuCl(dppe)2(C≡C-py-3)] (1) with copper or cadmium acetate in the presence of Schiff base ligands LH1–3 (where LH = 2-(pyrrole-2-yl-methylidine)aminophenol (LH1), 5-bromo-2-(pyrrole-2-yl-methylidine)aminophenol (LH2) and 5-nitro-2-(pyrrole-2-yl-methylidine)aminophenol (LH3)). The hybrid materials were characterized on the basis of elemental analyses, TEM, IR, UV–visible, 1H NMR, and 31P NMR spectral studies. TEM overview observations revealed well-dispersed spherical nanoparticles of ~60 nm are formed. Quasireversible redox behavior is observed for CuII/RuII complexes corresponding to CuI/CuII and RuII/RuIII couples. All the complexes exhibit blue-green emission as a result of fluorescence from the intraligand (π → π*) emission excited state with good quantum yield. The second-order nonlinear optical (NLO) properties of CuII/RuII and CdII/RuII complexes have been investigated by the Kurtz-powder method. The second harmonic generation efficiency of these complexes show that these complexes are NLO active and display good second-order nonlinear optical activity. 相似文献
158.
For improved stability of fluid-conveying pipes operating under the thermal environment, functionally graded materials (FGMs) are recommended in a few recent studies. Besides this advantage, the nonlinear dynamics of fluid-conveying FG pipes is an important concern for their engineering applications. The present study is carried out in this direction, where the nonlinear dynamics of a vertical FG pipe conveying hot fluid is studied thoroughly. The FG pipe is considered with pinned ends while the internal hot fluid flows with the steady or pulsatile flow velocity. Based on the Euler–Bernoulli beam theory and the plug-flow model, the nonlinear governing equation of motion of the fluid-conveying FG pipe is derived in the form of the nonlinear integro-partial-differential equation that is subsequently reduced as the nonlinear temporal differential equation using Galerkin method. The solutions in the time or frequency domain are obtained by implementing the adaptive Runge–Kutta method or harmonic balance method. First, the divergence characteristics of the FG pipe are investigated and it is found that buckling of the FG pipe arises mainly because of temperature of the internal fluid. Next, the dynamic characteristics of the FG pipe corresponding to its pre- and post-buckled equilibrium states are studied. In the pre-buckled equilibrium state, higher-order parametric resonances are observed in addition to the principal primary and secondary parametric resonances, and thus the usual shape of the parametric instability region deviates. However, in the post-buckled equilibrium state of the FG pipe, its chaotic oscillations may arise through the intermittent transition route, cyclic-fold bifurcation, period-doubling bifurcation and subcritical bifurcation. The overall study reveals complex dynamics of the FG pipe with respect to some system parameters like temperature of fluid, material properties of FGM and fluid flow velocity. 相似文献
159.
Motlalepula Gilbert Matsabisa Asis Bala Satyajit Tripathy Michelle Mogomane Digashu Fanie Rautenbach Barsha Dassarma Joseph Omorogiuwa Erhabor Fernao Castro Braga Pulok Kumar Mukherjee Minke Tang Youngmin Kang 《Molecules (Basel, Switzerland)》2022,27(11)
Background: This study comparatively assessed seven indigenous traditional tea plants on several attributes that included antioxidant, nutritional, caffeine contents, and cyclooxygenase activity. Methodology: Nutritional content of all tea plants were determined for energy, fat, carbohydrates, total sugars, dietary fiber and amino acids. Antioxidant potential and the antioxidant potentiating secondary metabolites were also measured and compared. Further, we investigated the tea plants for any role they would have on cyclooxygenase (COX) activity on cobalt chloride (CoCl2) induced human glioma cell lines (U87MG). Results: The tea plants were found non-cytotoxic at concentrations tested against the human Chang liver and HeK 293 kidney cells and were found to be naturally caffeine free. The lowest and highest extraction yield among the tea plants was 7.1% for B. saligna and 15.48% for L. scaberrimma respectively. On average, the flavonol content was 12 to 8 QE/g, ORAC 800 µmol TE/g, TEAC 150 µmol TE/g, FRAP 155 µmol AAE/g, polyphenols 40 mg GAE/g, flavanols 0.35 mg CE/g, flavonols 12 mg QE/g and total flavonoid content (TFC) 180 µg QE/mg. The COX activity has been found to be inhibited by a dose-dependent manner by L. scaberrimma, B. saligna and L. javanica. Conclusion: The results further support competitive value of tea plants and need for improved and further development. 相似文献
160.
Niteen B. Patil Ranjit S. Atapalkar Dr. Subhash P. Chavan Dr. Amol A. Kulkarni 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(70):17695-17699
Herein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3rd step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 % overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day. 相似文献