Spectrophotometric variable‐concentration kinetic experiments applied to inorganic reactions

The dependence of the observed rate constant of inorganic substitution reactions on the concentration of nucleophilic reagents was obtained by single variable‐parameter kinetic runs. The experiments were carried out spectrophotometrically, varying the concentration of the nucleophile inside the reaction vessel. Software and apparatus were developed for an easy and rapid performance. The method gives accurate results and a saving in time by a factor of up to 100 compared to conventional methods. © 2003 Wiley Periodicals, Inc. Int J Chem Kinet 35: 497–502, 2003     

Errata: Statistical Entropy of a Lattice-Gas Model: Multiparticle Correlation Expansion

Journal of Statistical Physics -     

Electrochemical reduction and oxidation of nitrogen through low-current electrolysis

Dissolved nitrogen is reduced to ammonia at a platinum cathode enclosed in a cellophane membrane and is oxidised to nitric acid at a similarly enclosed anode at very low current density (～1 mA/cm²), the electrolyte being distilled water. This is attributed to highly active reducing and oxidising species formed near the cathode and anode respectively under such low-current low-concentration condition of electrolysis.     

Il problema di Cauchy-Dirichlet per una classe di sistemi parabolici a coefficienti misurabili

Riassunto Si dimostrano teoremi di esistenza, di unicità e di regolarizzazione per la soluzione del problema di Cauchy-Dirichlet per una classe di sistemi parabolici a coefficienti misurabili.

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Summary We show that the Cauchy-Dirichlet problem for a class of parabolic systems with measurable coefficients admits a unique solution. We show, also, regularity's properties for the solution.

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Lavoro eseguito nell'ambito del gruppo G.N.A.F.A. del C.N.R.     

Combined ultraviolet-fluorescence detection in high-pressure liquid chromatography of pharmaceuticals.

The use of combined UV-fluorescence detection for the evaluation of incompletely resolved compounds and trace components in the presence of large quantities of major components is described, analysis for thioridazine and some of its oxidation products by high-pressure liquid chromatography being chosen as a practical example. Mesoridazine and the ring oxide of thioridazine have been determined quantitatively with relative standard deviations (n = 6) of 2.0 and 3.6%, respectively, at concentrations below 0.1 mug per injection. Resolution of the two components is difficult and, in this instance, unnecessary. By a similar approach, it was possible to determine the highly fluoresecent sulforidazine at a concentration of 0.4% of the thioridazine with 6.2 mug of thioridazine injected. A relative standard deviation of 5% was attainable at this concentration. Fluorescence detection limits for mesoridazine and sulforidazine at a signal-to-noise ratio of 4:1 are between 5 and 10 ng per injection; this corresponds to about 0.1% of the active substance for the above example.     

Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation

Ebselen is the leader of selenorganic compounds, and starting from its identification as mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have appeared in literature claiming its biological activities. It was the subject of several clinical trials and it is currently in clinical evaluation for the treatment of COVID-19 patients. Given our interest in the synthesis and pharmacological evaluation of selenorganic derivatives with this review, we aimed to collect all the papers focused on the biological evaluation of ebselen and its close analogues, covering the timeline between 2016 and most of 2021. Our analysis evidences that, even if it lacks specificity when tested in vitro, being able to bind to every reactive cysteine, it proved to be always well tolerated in vivo, exerting no sign of toxicity whatever the administered doses. Besides, looking at the literature, we realized that no review article dealing with the synthetic approaches for the construction of the benzo[d][1,2]-selenazol-3(2H)-one scaffold is available; thus, a section of the present review article is completely devoted to this specific topic.     

A measure of multivariate mutual complete dependence

The authors propose a multivariate version of Siburg and Stoimenov’s measure of mutual complete dependence. This multivariate version is, however, not the distance between a copula and the product copula $C_I$ under the modified Sobolev norm since the set of mutual complete dependence copulas does not lie on the sphere centered at $C_I$. To overcome this difficulty, the authors choose another center and define measures of complete dependence based on the modified Sobolev norm and this center. The measure of multivariate mutual complete dependence is then defined as the summation of the (normalized) measures of complete dependence.     

A domino approach to pyrazino- indoles and pyrroles using vinyl selenones

Herein we disclose an efficient and flexible approach to biologically relevant 3,4-dihydropyrazino[1,2-a]indol-1(2H)ones and 3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)ones through a domino Michael/intramolecular nucleophilic substitution pathway using potassium hydroxide in dichloromethane. Variously substituted vinyl selenones and 1H-indole-2-carboxamides or 1H-pyrrole-2-carboxamides have been employed with success in chemo and regio-selective processes. The introduction of an amino acid portion on the amidic function is well tolerated without racemization.