Atmospheric-Pressure Plasma Reduction of Metal Cation-Containing Polymer Films to Produce Electrically Conductive Nanocomposites by an Electrodiffusion Mechanism

We describe an atmospheric-pressure plasma process for the reduction of metal cation-containing polymer films to form electrically conductive patterns. Thin films of poly(acrylic) acid (PAA) containing silver ions (Ag⁺) were prepared by mixing the polymer with silver nitrate (AgNO₃) in solution to produce a cross-linked precipitate, homogenizing, and depositing onto a substrate by doctor’s blade. Exposing the Ag–PAA films to a scanning microplasma resulted in reduction of the bulk dispersed Ag⁺ in a desired pattern at the film surface. The processed films were characterized by scanning electron microscopy, energy dispersive spectroscopy, thermogravimetric analysis, and current–voltage measurements. The resistances of the patterned features were found to depend on the thickness of the films, the microplasma scan rate, residual solvent in the film, and electric field created between the microplasma and the substrate. Together these results show that the formation of conductive features occurs via an electrodiffusion process where Ag⁺ diffuses from the film bulk to the surface to be reduced by the microplasma.     

Mass Spectrometry Based Mechanistic Insights into Formation of Tris Conjugates: Implications on Protein Biopharmaceutics

We present here extensive mass spectrometric studies on the formation of a Tris conjugate with a therapeutic monoclonal antibody. The results not only demonstrate the reactive nature of the Tris molecule but also the sequence and reaction conditions that trigger this reactivity. The results corroborate the fact that proteins are, in general, prone to conjugation and/or adduct formation reactions and any modification due to this essentially leads to formation of impurities in a protein sample. Further, the results demonstrate that the conjugation reaction happens via a succinimide intermediate and has sequence specificity. Additionally, the data presented in this study also shows that the Tris formation is produced in-solution and is not an in-source phenomenon. We believe that the facts given here will open further avenues on exploration of Tris as a conjugating agent as well as ensure that the use of Tris or any ionic buffer in the process of producing a biopharmaceutical drug is monitored closely for the presence of such conjugate formation.

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Spinodal decomposition in a model colloid-polymer mixture in microgravity

We study phase separation in a deeply quenched colloid-polymer mixture in microgravity on the International Space Station using small-angle light scattering and direct imaging. We observe a clear crossover from early-stage spinodal decomposition to late-stage, interfacial-tension-driven coarsening. Data acquired over 5 orders of magnitude in time show more than 3 orders of magnitude increase in domain size, following nearly the same evolution as that in binary liquid mixtures. The late-stage growth approaches the expected linear growth rate quite slowly.     

A modified evidential methodology of identifying influential nodes in weighted networks

How to identify influential nodes in complex networks is still an open hot issue. In the existing evidential centrality (EVC), node degree distribution in complex networks is not taken into consideration. In addition, the global structure information has also been neglected. In this paper, a new Evidential Semi-local Centrality (ESC) is proposed by modifying EVC in two aspects. Firstly, the Basic Probability Assignment (BPA) of degree generated by EVC is modified according to the actual degree distribution, rather than just following uniform distribution. BPA is the generation of probability in order to model uncertainty. Secondly, semi-local centrality combined with modified EVC is extended to be applied in weighted networks. Numerical examples are used to illustrate the efficiency of the proposed method.     

On Growth Types of Quotients of Coxeter Groups by Parabolic Subgroups

The principal objects studied in this note are infinite, non-affine Coxeter groups W. A well-known result of de la Harpe asserts that such groups have exponential growth. We study the growth type of quotients of W by parabolic subgroups and by a certain class of reflection subgroups. Our main result is that these quotients have exponential growth as well.     

Methodology for studying particle–particle triboelectrification in granular materials

A critical challenge for experimental studies of triboelectric charging is to generate reproducible and unambiguous data that can be linked to theoretical concepts. We have developed a methodology to investigate the triboelectric charging of granular materials due solely to particle–particle interactions (i.e. no particle–wall interactions). The methodology is based on a particle flow apparatus that generates a fountain-like flow in which the particles contact only other particles, but no equipment surfaces. Non-contact methods of measuring charge and separating particles by charge are employed so that probe-particle charging does not occur.     

Unsteady deflagration speed of an auto-ignitive dimethyl-ether (DME)/air mixture at stratified conditions

The propagation speed of an auto-ignitive dimethyl-ether (DME)/air mixture at elevated pressures and subjected to monochromatic temperature oscillations is numerically evaluated in a one-dimensional statistically stationary configuration using fully resolved numerical simulations with reduced kinetics and transport. Two sets of conditions with temperatures within and slightly above the negative temperature coefficient (NTC) regime are simulated to investigate the fundamental aspects of auto-ignition and flame propagation along with the transition from auto-ignitive deflagration to spontaneous propagation regimes under thermal stratification. Contrary to the standard laminar flame speed, the steady propagation speed of an auto-ignitive front is observed to scale proportionally to its level of upstream reactivity. It is shown that this interdependence is primarily influenced by the characteristic residence time and the homogeneous auto-ignition delay. Furthermore, the unsteady reaction front in either of the two cases responds distinctly to the imposed stratification. Specifically, the results in both cases show that the dynamic flame response depends on the mean temperature at the flame base T_b and the time-scale of thermal stratification. It is also found that, based on T_b and the propensity of the mixture to two-stage chemistry, the instantaneous peak propagation speed and the overall time taken to achieve that speed differs considerably. A displacement speed analysis is carried out to elucidate the underlying combustion modes that are responsible for such a variation in flame response.     

Monitoring redox-sensitive paramagnetic contrast agent by EPRI, OMRI and MRI

A comparative study of tissue redox-status imaging using commonly used redox sensitive nitroxides has been carried out using electron paramagnetic resonance imaging (EPRI), Overhauser magnetic resonance imaging (OMRI) and conventional T(1)-weighted magnetic resonance imaging, MRI. Imaging studies using phantoms of different nitroxides at different concentration levels showed that EPRI and OMRI sensitivities were found to be linearly dependent on line width of nitroxides up to 2 mM, and the enhancement in MRI intensity was linear up to 5 mM. The sensitivity and resolution of EPRI and OMRI images depended significantly on the line width of the nitroxides whereas the MRI images were almost independent of EPR line width. Reduction of the paramagnetic 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (3CP) by ascorbic acid (AsA) to the diamagnetic by hydroxylamine was monitored from a sequence of temporal images, acquired using the three imaging modalities. The decay rates determined by all the three modalities were found to be similar. However the results suggest that T(1)-weighted MRI can monitor the redox status, in addition to providing detailed anatomical structure in a short time. Therefore, a combination of MRI with nitroxides as metabolically responsive contrast agents can be a useful technique for the in vivo imaging probing tissue redox status.     

On degrees of maps between Grassmannians

Let G_n,k denote the oriented grassmann manifold of orientedk-planes in ℝⁿ. It is shown that for any continuous mapf: G_n,k → G_n,k, dim G_n,k = dim G_m,l = l(m −l), the Brouwer’s degree is zero, providedl > 1,n ≠ m. Similar results for continuous mapsg: ℂG_m,l → ℂG_n,k,h: ℍG_m,l → ℍG_n,k, 1 ≤ l < k ≤ n/2, k(n — k) = l(m — l) are also obtained.     

Colloidal Flower‐Shaped Iron Oxide Nanoparticles: Synthesis Strategies and Coatings

The assembly of magnetic cores into regular structures may notably influence the properties displayed by a magnetic colloid. Here, key synthesis parameters driving the self‐assembly process capable of organizing colloidal magnetic cores into highly regular and reproducible multi‐core nanoparticles are determined. In addition, a self‐consistent picture that explains the collective magnetic properties exhibited by these complex assemblies is achieved through structural, colloidal, and magnetic means. For this purpose, different strategies to obtain flower‐shaped iron oxide assemblies in the size range 25–100 nm are examined. The routes are based on the partial oxidation of Fe(OH)₂, polyol‐mediated synthesis or the reduction of iron acetylacetonate. The nanoparticles are functionalized either with dextran, citric acid, or alternatively embedded in polystyrene and their long‐term stability is assessed. The core size is measured, calculated, and modeled using both structural and magnetic means, while the Debye model and multi‐core extended model are used to study interparticle interactions. This is the first step toward standardized protocols of synthesis and characterization of flower‐shaped nanoparticles.