A Convenient Synthesis of (-)-Methyl Epijasmonate

A short, enantioselective synthesis of (-)-methyl epi-jasmonate, ent-1, has been achieved starting from readily available Corey lactone aldehyde 9. The key features include the stereoselective installation of 2,3-cis-disubstituted side-chains by hydrogenation of dienoate 8 and subsequent one-carbon degradation.     

Dynamics of the two-dimensional melting transition of a liquid crystal confined in Anopore membranes

Dielectric measurements on a liquid crystal exhibiting the smectic A-crystal B transition and confined to Anopore membranes having 20 and 200 nm pore sizes are reported. The studies reveal that compared with the bulk, the confined material shows a decrease in transition temperature. More importantly, the confinement leads to a slowing of the relaxation mechanism by about three orders of magnitude.     

Structural,thermal, and electrical studies of sodium iodide (NaI)-doped hydroxypropyl methylcellulose (HPMC) polymer electrolyte films

Solid polymer electrolyte films based on hydroxypropyl methylcellulose (HPMC) complexed with sodium iodide (NaI) were prepared using solution cast method. The dissolution of the salt into the polymer host and the structural properties of pure and complexed HPMC polymer electrolyte films were confirmed by X-ray diffraction (XRD) studies. XRD results revealed that the amorphous domains of HPMC polymer matrix were increased with increase in NaI salt concentration. The degree of crystallinity was found to be high in pure HPMC samples. The thermal properties were studied using differential scanning calorimetry (DSC). DSC results revealed that the presence of NaI in the polymer matrix increases the melting temperature; however, it is observed that fusion heat is high for pure HPMC films. The variation of film morphology was examined by scanning electron microscopy. Fourier transform infrared spectral studies revealed vibrational changes that occurred due to the effect of dopant salt in the polymer. Direct current conductivity was measured in the temperature range of 313–383 K. The magnitude of electrical conductivity was found to increase with the increase in salt and temperature concentration. The data on the activation energy regions (regions I and II) indicated the dominance of ion-type charge transport in these polymer electrolyte films. The composition HPMC:NaI (5:4) is found to exhibit the least crystallinity and the highest conductivity.     

Determination of lipid‐soluble arsenic species in seaweed‐eating sheep from Orkney

This work is part of an ongoing research study towards an understanding of the complete metabolism of arsenosugars in mammalian organisms when ingesting seaweed, using the North Ronaldsay (NR) sheep as a model organism. We focus on the analysis of only those arsenic species bound to the lipids of the feed (Laminaria digitata), faeces and the tissues of the NR sheep using a novel enzymatic hydrolytic method that is simple and reliable. This rare breed of sheep, found in the remote Orkney Islands in the north of Scotland, live the entire year on the beaches and eat seaweed that is washed ashore (up to 3 kg daily). Previous studies on arsenic fractionation in muscle, kidney and liver tissues revealed that most of the arsenic is concentrated in the fat fractions of these tissues (muscle fat: 61%; liver fat: 66%; kidney fat: 25%) rather than in the non‐lipid fractions. Hence, this study was undertaken in order to determine the arsenic species bound to lipids in the muscle, kidney and faeces of NR sheep and to compare these with the arsenic species bound to the lipids of the L. digitata consumed. The enzymatic hydrolytic procedure has been successfully employed for the first time to cleave the arsenic species cleanly from the rest of the lipid structure. This makes the arsenic species water soluble and enables their direct determination by high‐performance liquid chromatography coupled with inductively coupled plasma mass spectrometry. Dimethylarsinic acid (DMA(V)) and monomethylarsonic acid (MA(V)) were found to be the major hydrolysed arsenic species bound to the kidney and muscle lipids, whereas arsenosugar‐1 was found to be the major hydrolysed arsenic species in L. digitata lipids. On the other hand, DMA(V) was found to be the major arsenical obtained after the enzymatic hydrolysis of the faeces lipids. These results seem to suggest that both direct absorption and biotransformation of the absorbed organoarsenicals are the likely reasons for their occurrence and accumulation in the NR sheep tissues. Copyright © 2003 John Wiley & Sons, Ltd.     

Effect of pressure on liquid crystal dimers

We report high pressure investigations on a homologous series of liquid crystalline dimeric molecules in which the terminal chain length is kept constant but the length of the methylene spacer connecting the two mesogenic units is varied. We find that unlike the nematic-isotropic transition temperature and associated entropy change, there is no alternation in the slope of the nematic-isotropic phase boundary in the pressure-temperature plane as a function of the length of the spacer group in the molecule. By applying the Clausius-Clapeyron equation we conclude that the volume change at the transition should exhibit a strong odd-even effect. Measurements on the shortest homologue of the series, which is non-mesomorphic, show the expected result that the application of pressure induces mesomorphism in non-mesomorphic compounds.     

Verteprofin conjugated to gold nanoparticles for fluorescent cellular bioimaging and X-ray mediated photodynamic therapy

Microchimica Acta - Photodynamic therapy (PDT) uses photosensitizers, light and molecular oxygen to generate cytotoxic reactive oxygen species. Its effectiveness is limited to <1 cm...     

Electrical conductivity and dielectric constant measurements of liquid crystal–gold nanoparticle composites

The behaviour of the anisotropic electrical conductivity of liquid crystal–gold nanoparticle (LC‐GNP) composites consisting of a commercially available room temperature nematic compound doped with alkylthiol‐capped GNPs has been investigated. The nematic–isotropic transition of the composite decreases nearly linearly with increasing X, the concentration of GNP (in weight %) at a rate of about 1°C /weight %. The inclusion of GNPs increases the electrical conductivity of the system with the value increasing by more than two orders of magnitude for X = 5%. However, the anisotropy in conductivity, defined as the ratio of the conductivity along (σ_∥) and orthogonal (σ_⊥) to the director shows a much smaller but definite decrease as X increases.     

Queueing network modelling of flexible manufacturing system using mean value analysis

In the present investigation, we develop queueing model for the performance prediction of flexible manufacturing systems (FMSs) with a multiple discrete material-handling devices (MHD). An iterative method has been suggested using mean value analysis (MVA) for the state-dependent routing. Two queueing network models are considered to determine the material-handling device interference. In the first one, we model the interference from the MHD by inflating the station service times but neglect queueing at the MHD. In another network, the queueing for the MHD is taken into consideration. The performance of FMS configuration is obtained by iterating between two networks. The suggested algorithms demonstrate better results than the algorithm used by earlier workers for single MHD. Some performance indices viz. throughput, mean service time, mean waiting time, etc. are obtained. Numerical results are provided to highlight the effect of the system parameters on performance indices, which are further evaluated by using neuro-fuzzy controller system to validate the tactability of soft computing approach.     

Influence of protons on backbending

Backbending in (at least the first half of) the rare earth nuclei seems to be determined by the alignment of an $\text{i}{}_{\mathrm{<mtext>13</mtext><mtext>2</mtext>}}$ neutron pair. This is supported by the disappearance of backbending due to the blocking of an $\text{i}{}_{\mathrm{<mtext>13</mtext><mtext>2</mtext>}}$ level by an odd neutron for example in ¹⁶⁵Yb. Contrary to expectations backbending disappears also by adding an odd $\text{h}{}_{\mathrm{<mtext>9</mtext><mtext>2</mtext>}}$,proton to ₇₀¹⁶⁶Yb in ₇₁¹⁶⁷Lu for this state (but is present if the odd proton is in the $\text{g}{}_{\mathrm{<mtext>7</mtext><mtext>2</mtext>}}$ level). A theory is presented which explains the odd neutron and the odd proton nuclei. It turns out that the odd proton in ¹⁶⁷Lu serves only as a type of catalyst for the alignment of an $\text{i}{}_{\mathrm{<mtext>13</mtext><mtext>2</mtext>}}$ neutron pair. The odd proton changes the deformation and moves the Fermi surface nearer ($\text{g}{}_{\mathrm{<mtext>7</mtext><mtext>2</mtext>}}$) or farther away ($\text{h}{}_{\mathrm{<mtext>9</mtext><mtext>2</mtext>}}$) from the nearest $\text{i}{}_{\mathrm{<mtext>13</mtext><mtext>2</mtext>}}$ neutron level. In one case one finds backbending and in the other case no backbending in ¹⁶⁷Lu.