Energies,fine structures,and transition rates of the core‐excited states in BeII

The energies and fine structures of some doubly excited resonances of lithiumlike beryllium are calculated using the saddle‐point variational method. A restricted variational method is used to extrapolate a better nonrelativistic energy. Relativistic and mass polarization corrections are included. Oscillator strengths, transition rates, and wavelengths are also calculated. The results are compared with other theoretical and experiment data in the literature. © 2000 John Wiley & Sons, Inc. Int J Quant Chem 76: 656–661, 2000     

锌的表面增强喇曼散射效应

本文从莫育俊等人提出的天线共振子模型理论出发,计算了金属锌的SERS增强特性。天线共振子模型预言,在可见光区,锌的增强因子最大为10,而在红外则会达到很大的增强(10⁵以上).同时,我们通过实验分析了金属锌的SERS增强特性,得到了在可见光区锌的增强因子约为230.在考虑化学增强的情况下,理论计算结果同实验基本一致。     

The Angular Distributions of intermediate Mass Fragments Emittsd in 30 MeV/u 40Ar+58,64Ni and 115In Reactions

The angular distributions of intermediate mass fragments with Z=3-19 emitted in 30 MeV/u ⁴⁰Ar+^58,64Ni and ¹¹⁵In reactions over an angular range of 5°—140°have been measured.Exponential distribution function: dσ/dΩ=N·exp(-θ/a) was used tO fit the measured angular distributions.We have extracted the decay factor a that can be connected with the interaction time τ, and the factor N that is related to the intensity of the emission source.The relationships of a(Z) with Z and N(Z) with Z for different reaction systems and different angular ranges have been discussed. The dependence of angular distributions on isospin and the symmetry of reaction system have also been discussed.     

Element Distributions of Intermediate Mass Fragments Emitted in 30 MeV/u 40Ar+58,64Ni and 115In Reactions

The element distribuhons of intermediate mass fragments (IMF) emitted over an angular region of 5°—140° have been measured in the reachons of 30MeV/u ⁴⁰Ar+^58,64Ni and ¹¹⁵In. Within 20°—80° range the IMFs with Z=3-24 were observed. The IMF production cross section changes smoothly with its charge number,and the element distribuhon changes continuously when the IMF charge number increases across the charge number of the projectile. There is no strong dependence of the element distribution on the charge number of the projectile in this angular region.The transition nature of the reaction mechanism in the intermediate energy region and the power law of the IMF element distribution,as well as the dependence of element distributions on the threshold of the detectors were discussed.     

压缩双裂纹和单裂纹圆孔板应力强度因子公式

从理论模型和数值分析上澄清了国外文献关于压缩双裂纹圆孔板(double cleavage drilled compression,DCDC) 的应力强度因子不同的公式引起的混淆. 证明Plaisted 等用修正压缩无限大板中圆孔双边裂纹的解和欧拉-伯努利梁理论得到的DCDC 应力强度因子公式都存在推导和原理性的失误. 指出Jenne 等推导的公式形式过于复杂不便使用, 而He 等的公式适用范围偏小. 通过拟合有限元法宽范围数值计算结果导出DCDC 的应力强度因子的新公式, 该公式形式简单, 对无量纲裂纹长度和无量纲板宽度适用范围较大, 最大误差是7%. 此外, 还对新提出的压缩单裂纹圆孔板(single cleavage drilled compression, SCDC)做了分析, 首次得到的SCDC应力强度因子公式的最大误差是5%. 给出的2 个公式可分别用于脆性材料DCDC 或SCDC 试样的断裂韧度测试.     

A rapid and sensitive UPLC–MS/MS method for the determination of zanubrutinib in beagle plasma and its application in pharmacokinetics

A reliable and sensitive ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for the determination of zanubrutinib in the plasma of beagle dogs. The column used was an Acquity BEH C₁₈ column (2.1 mm × 50 mm, 1.7 μm), maintained at 40°C with an injection volume of 2 μl. The gradient elution program was as follows: 0–1 min, 10–10% A; 1–1.1 min, 10–90% A; 1.1–2.1 min, 90–90% A; 2.1–2.2 min, 90–10% A; 2.2–3.0 min, 10–10% A. Mobile phase A was 0.1% formic acid, B was acetonitrile, and the total analysis time was 3 min. The mass spectrometry was performed in positive ion mode, and the scanning mode was multi-reaction monitoring mode with electrospray ionization as the ion source; m/z 472.2 → 455.01 for zanubrutinib and m/z 441.03 → 137.99 for ibrutinib (internal standard). The plasma samples were processed by protein precipitation. The standard curve showed good linearity (r² = 0.999 8) in the range of 1.0–1,000 ng/ml (zanubrutinib) with a low limit of quantification of 1 ng/ml. Also, the intra-day and inter-day precision (RSD) was <5.88% and the accuracy (RE) ranged from −1.56 to 1.08%; the recoveries of zanubrutinib in beagle plasma ranged from 90.12 to 93.53% (RSD 1.67–6.42%) and the ME values of zanubrutinib were 98.70–101.06% (RSD 5.37–8.49%, n = 6). All values meet US Food and Drug Administration requirements. A rapid, highly selective and sensitive method for the determination of zanubrutinib concentration in plasma by UPLC–MS/MS was successfully developed. This method is suitable for pharmacokinetic studies in beagle dogs by following oral administration of zanubrutinib.     

Zn的高离化态光谱

用SGV-50型正入射式真空紫外谱仪拍摄了三电极触发火花光源的Zn的高离化光谱。在光谱分析方法研究基础上、对Zn光谱进行了分析。证实了ZnⅢ、ZnⅣ和ZnⅤ的3d~k4s和3d~k4p(k=9,8,7)组态现有光谱的分析结果。通过ZnⅣ3d~84d-3d~84p组态跃迁的分析导出了3d~84d组态的19条能级。     

Programming Super DNA-Enzyme Molecules for On-Demand Enzyme Activity Modulation**

Dynamic interactions of enzymes, including programmable configuration and cycling of enzymes, play important roles in the regulation of cellular metabolism. Here, we constructed a super DNA-enzymes molecule (SDEM) that comprises at least two cascade enzymes and multiple linked DNA strands to control and detect metabolism. We found that the programmable SDEM, which comprises glucose oxidase (GOx) and horseradish peroxidase (HRP), has a 20-fold lower detection limit and a 1.6-fold higher reaction rate than free enzymes. An SDEM can be assembled and disassembled using a hairpin structure and a displacement DNA strand to complete multiple cycles. An entropically driven catalytic assembly (catassembly) enables different SDEMs to switch from an SDEM with GOx and HRP cascades to an SDEM with sarcosine oxidase (SOX) and HRP cascades in over six orders of magnitude less time than without the catassembly to detect different metabolisms (GO and sarcosine) on demand.     

Authentication of Cyathulae Radix and Cyathulae Capitatae Radix based on the strength of the characteristic component achybidensaponin I

Because of the immense difficulty in identifying Cyathulae Capitatae Radix adulteration in Cyathulae Radix, this research aims at fortifying the quality control of Cyathulae Radix and its decoction pieces to guarantee the effectiveness and safety of its clinical use in terms of source material. A method was devised to identify Cyathulae Capitatae Radix adulteration in Cyathulae Radix and its decoction pieces. This research takes achybidensaponin I, that is, the characteristic component of Cyathulae Capitatae Radix, as reference substance and adopts HPLC for detection. The results revealed that, among all samples collected, no trace of achybidensaponin I was found in the 21 batches of Cyathulae Radix, whereas achybidensaponin I was found in all the 14 batches of Cyathulae Capitatae Radix. The research sets 5% as the adulteration limit, that is, 1.45 mg/g Cyathulae Capitatae Radix was detected in 57.14% of the 49 batches of market samples collected and the ratio was 51.02% in the case of 5% adulteration limit. The method is not only precise and reliable but can also be used as a supplement for provisions regarding quality control of Cyathulae Radix and its decoction pieces in Pharmacopoeia of the People's Republic of China, to effectively crack down on Cyathulae Capitatae Radix adulteration in the market.     

In situ synthesis of Bi3+-doped δ-MnO2 cathode to enhance the cycle stability for aqueous zinc-ion batteries

Journal of Solid State Electrochemistry - Bi3+-doped δ-MnO2 materials (BMX, X = 5, 10, 15) with long cycle life were obtained by an in situ electrochemical reaction using...