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91.
Shimizu S Miura A Khene S Nyokong T Kobayashi N 《Journal of the American Chemical Society》2011,133(43):17322-17328
Following the first suggestion of inherent molecular chirality in asymmetrically substituted subphthalocyanines by Torres and co-workers in 2000, elucidation of the relationship between structure and chirality has become an important issue. However, separation of the enantiomers has been prevented by the low solubility of the molecules synthesized to date, and it has not been possible to link the CD signs and intensities to their absolute structures. Recently, we observed that 1,2-subnaphthalocyanines possess two diastereomers with respect to the arrangement of the naphthalene moieties and that these novel chiral molecules exhibit moderate solubility in common organic solvents. This has enabled us to separate all of the diastereomers and enantiomers. The two diastereomers have been completely characterized by NMR spectroscopy and X-ray diffraction analysis. The absorption and magnetic circular dichroism spectra, together with theoretical calculation, reveal a small variation in the frontier molecular orbitals of the 1,2-subnaphthalocyanines compared with conventional subphthalocyanines, except for destabilization of the HOMO-3, which results in a characteristic absorption in the Soret band region. The chirality of 1,2-subnaphthalcyanines, including the CD signs and intensities, is discussed in detail for the first time with enantiomerically pure molecules whose absolute structures have been elucidated by single-crystal X-ray diffraction analysis. 相似文献
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The filter operates with a two-level system and affects the emission kinetics of the laser; allowance is made for the effects of pumping in the laser and of relaxation in the laser and filter. It is found that oscillation with several peaks is possible. The requirements for single-peak operation are formulated. Examples are given of emission calculations, with analytic estimates of the output power, energy, and pulse length. 相似文献
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Several natural products (NPs) have displayed varying in vitro activities against methicillin-resistant Staphylococcus aureus (MRSA). However, few of these compounds have not been developed into potential antimicrobial drug candidates. This may be due to the high cost and tedious and time-consuming process of conducting the necessary preclinical tests on these compounds. In this study, cheminformatic profiling was performed on 111 anti-MRSA NPs (AMNPs), using a few orally administered conventional drugs for MRSA (CDs) as reference, to identify compounds with prospects to become drug candidates. This was followed by prioritizing these hits and identifying the liabilities among the AMNPs for possible optimization. Cheminformatic profiling revealed that most of the AMNPs were within the required drug-like region of the investigated properties. For example, more than 76% of the AMNPs showed compliance with the Lipinski, Veber, and Egan predictive rules for oral absorption and permeability. About 34% of the AMNPs showed the prospect to penetrate the blood–brain barrier (BBB), an advantage over the CDs, which are generally non-permeant of BBB. The analysis of toxicity revealed that 59% of the AMNPs might have negligible or no toxicity risks. Structure–activity relationship (SAR) analysis revealed chemical groups that may be determinants of the reported bioactivity of the compounds. A hit prioritization strategy using a novel “desirability scoring function” was able to identify AMNPs with the desired drug-likeness. Hit optimization strategies implemented on AMNPs with poor desirability scores led to the design of two compounds with improved desirability scores. 相似文献
99.
ukasz Kuterasiski Magorzata Smolio-Utrata Joanna Kaim Wojciech Rojek Jerzy Podobiski Katarzyna Samson Dorota Duraczyska Magorzata Zimowska Mariusz Gackowski Dorota Rutkowska-Zbik 《Molecules (Basel, Switzerland)》2021,26(7)
The aim of the present paper is to study the speciation and the role of different active site types (copper species and Brønsted acid sites) in the direct synthesis of furan from furfural catalyzed by copper-exchanged FAU31 zeolite. Four series of samples were prepared by using different conditions of post-synthesis treatment, which exhibit none, one or two types of active sites. The catalysts were characterized by XRD, low-temperature sorption of nitrogen, SEM, H2-TPR, NMR and by means of IR spectroscopy with ammonia and CO sorption as probe molecules to assess the types of active sites. All catalyst underwent catalytic tests. The performed experiments allowed to propose the relation between the kind of active centers (Cu or Brønsted acid sites) and the type of detected products (2-metylfuran and furan) obtained in the studied reaction. It was found that the production of 2-methylfuran (in trace amounts) is determined by the presence of the redox-type centers, while the protonic acid sites are mainly responsible for the furan production and catalytic activity in the whole temperature range. All studied catalysts revealed very high susceptibility to coking due to polymerization of furfural. 相似文献
100.
Development of a colloidal gold-based lateral-flow immunoassay for the rapid simultaneous detection of zearalenone and deoxynivalenol 总被引:1,自引:0,他引:1
Kolosova AY De Saeger S Sibanda L Verheijen R Van Peteghem C 《Analytical and bioanalytical chemistry》2007,389(7-8):2103-2107
A multianalyte lateral-flow technique using colloidal gold-labeled monoclonal antibodies was developed for the rapid simultaneous
detection of deoxynivalenol (DON) and zearalenone (ZEA). The results of this qualitative one-step test were interpreted visually.
A very simple and fast sample preparation was used, and the assay procedure could be accomplished within 10 min. When applied
to spiked wheat samples, the technique gave accurate and reproducible results. Cut-off levels of 1500 and 100 μg kg−1 for DON and ZEA, respectively, were observed. The described multianalyte format can be used as a reliable, rapid and cost-effective
on-site screening technique for the simultaneous determination of mycotoxins in grain samples. 相似文献