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121.
Effect of Cold Atmospheric Plasma Jet Associated to Polyene Antifungals on Candida albicans Biofilms
Lady Daiane Pereira Leite Maria Alcionia Carvalho de Oliveira Mariana Raquel da Cruz Vegian Aline da Graa Sampaio Thalita Mayumi Castaldelli Nishime Konstantin Georgiev Kostov Cristiane Yumi Koga-Ito 《Molecules (Basel, Switzerland)》2021,26(19)
The increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold atmospheric plasma (CAP) has been proposed as a promising alternative technique for the treatment of superficial candidiasis, with inhibitory effect both in vitro and in vivo. However, little is known on the association of CAP with conventional antifungals. The aim of this study was to evaluate the effects of the association between CAP and conventional polyene antifungals on Candida albicans biofilms. C. albicans SC 5314 and a clinical isolate were used to grow 24 or 48 h biofilms, under standardized conditions. After that, the biofilms were exposed to nystatin, amphotericin B and CAP, separately or in combination. Different concentrations of the antifungals and sequences of treatment were evaluated to establish the most effective protocol. Biofilms viability after the treatments was compared to negative control. Data were compared by One-way ANOVA and post hoc Tukey (5%). The results demonstrate that 5 min exposure to CAP showed more effective antifungal effect on biofilms when compared to nystatin and amphotericin B. Additionally, it was detected that CAP showed similar (but smaller in magnitude) effects when applied in association with nystatin and amphotericin B at 40 µg/mL and 60 µg/mL. Therefore, it can be concluded that the application of CAP alone was more effective against C. albicans biofilms than in combination with conventional polyene antifungal agents. 相似文献
122.
Nonlinear Dynamics - This work analyzes a multiphysics system with stick–slip oscillations. The system is composed of two subsystems that interact, a mechanical and an electromagnetic (a DC... 相似文献
123.
Jéssica Maria de Souza Bruno Rodrigues Fazolo Jhully Wellen Ferreira Lacerda Mariana de Souza Moura Arielly Celestino Rodrigues dos Santos Leonardo Gomes de Vasconcelos Paulo Teixeira de Sousa Junior Evandro Luiz Dall’Oglio Akbar Ali Olívia Moreira Sampaio Lucas Campos Curcino Vieira 《Photochemistry and photobiology》2020,96(6):1233-1242
We report the synthesis of twelve indole derivatives bearing nitro or amide groups via Fischer indole methodology followed by reduction/acetylation and amidation reactions. After thorough characterization, these indoles were subjected to a number of studies in order to evaluate their bioactive potential as photosynthesis and plant growth inhibitors. Firstly, these molecular hybrids were evaluated as photosystem II (PSII) inhibitors through chlorophyll a (Chl a) fluorescence measurement. In this study, 6-chloro-8-nitro-2,3,4,9-tetrahydro-1H-carbazole ( 15a ) and 5-chloro-2,3-dimethyl-7-nitro-1H-indole ( 15b ) showed the best results by reducing the phenomenological parameters of reaction centers ABS/RC, TR0/RC and ET0/RC of PSII. Electron chain blockage by these compounds may lead to diminished ATP synthesis and CO2 fixation which interrupt the plant development. The compounds 15a and 15b both act as postemergent herbicides, reducing the dry biomass of Ipomoea grandifolia and Senna alata weeds by an average of 40% and 37%, respectively, corroborating the fluorescence results. Additionally, the molecular docking study revealed that the presence of strong electron-withdrawing groups at the indole phenyl ring is important for the ligand’s interaction with the binding pocket of protein D1 on PSII. The optimization of these molecular features is the goal of our research group in further understanding and development of new potent herbicides. 相似文献
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Bitencourt VL de Paula TA da Matta SL Fonseca CC dos Anjos Benjamin L Costa DS 《Micron (Oxford, England : 1993)》2007,38(6):584-589
The duration of the seminiferous epithelium cycle was estimated in adult maned wolves (Chrysocyon brachyurus, Illiger, 1811), by applying intratesticular injections with tritiated thymidine. The total duration of the seminiferous epithelium cycle in this species was calculated in 8.99 days. So, taking into account that approximately 4.5 cycles of the seminiferous epithelium are necessary for the whole spermatogenesis process to complete, the production of spermatozoa from one spermatogonia will take about 40.45 days. The duration of the spermiogenesis was calculated to be 12.3 days. The eight stages of the seminiferous epithelium cycle were described by the tubular morphology method, which is based either on the form and position of the spermatid nuclei and the occurrence of meiotic divisions. The values of the relative frequency for the pre-meiotic, meiotic and post-meiotic phases in this species were 3.5, 0.78 and 4.8 days, respectively. The maned wolf produces about 29 million spermatozoa a day for each testis gram, therefore being classified among the species provided with a high spermatogenetic efficiency. 相似文献
126.
Rita de Cássia Almeida Sampaio Russany Silva da Costa Claudia Regina Fernandes de Souza Anivaldo Pereira Duarte Júnior Roseane Maria Ribeiro-Costa Carlos Emmerson Ferreira da Costa Wanderley Pereira de Oliveira Attilio Converti José Otávio Carréra Silva Júnior 《Journal of Thermal Analysis and Calorimetry》2016,123(3):2469-2475
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Jose V. Silveira Luciana L. Vieira Josue Mendes Filho Antonio J. C. Sampaio Oswaldo L. Alves Antonio G. Souza Filho 《Journal of Raman spectroscopy : JRS》2012,43(10):1407-1412
This paper reports a study of vibrational, structural and morphological properties of molybdenum oxide nanoribbons. Temperature‐dependent Raman spectroscopy measurements in MoO3 nanoribbons revealed morphological changes in the 150–350 °C temperature range. No structural phase transitions were observed, thus showing that the orthorhombic phase is stable from room temperature (nanoribbons) up to 650 °C (bulk‐like phase) where large plates have been formed by the coalescence of the nanoribbons. The interpretation of temperature‐dependent Raman data (wavenumber and linewidths) is supported by scanning electron microscopy that is used to directly probe the morphological changes in MoO3 samples. The observed phenomena in the Raman data for MoO3 nanoribbons can be applied to other nanomaterials. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
130.
O'Brien L Lewis ER Fernández-Pacheco A Petit D Cowburn RP Sampaio J Read DE 《Physical review letters》2012,108(18):187202
In domain wall (DW) excitation experiments, nonlinearity (NL) intrinsic to the DW dynamics is often hard to distinguish from perturbation due to the confining potential or DW distortion. Here we numerically investigate the dynamic oscillations of magnetostatically coupled DWs: a system well understood in the quasistatic limit. NL is observed, even for a harmonic potential, due to the intrinsic DW motion. This behavior is principally dependent on terms normally associated with the DW canonical momentum and is in contrast with a NL restoring potential. This NL is not observable in quasistatic measurements, relatively insensitive to the confining potential, and may be tuned by the nanowire parameters. The shown NLs are present in any DW restoring potential and must be accounted for when probing DW potential landscapes. 相似文献