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101.
102.
Youssef M. Quinelato A. Youssef F. Pelino J. E. Pelizon Salvadori M. C. Mori M. 《Laser Physics》2008,18(4):472-477
We compare an ultrasound bur with a conventional one and an Er:YAG laser for cavity preparations. Human molars were embedded in resin and sliced for this study. The surface abrasion was performed by a high-speed instrument and ultrasound. The cavity preparation was initially performed with a high-speed diamond bur. After this, a 2.94-μm laser with 400 mJ/pulse at 4 Hz, and a pulse width from 250–500 μs was applied to the tooth surface for 30 s in a sweeping motion. The samples were analyzed by SEM. The abrasion surface with a conventional bur showed structure removal with different grooves, a smear-layer presence, and occluded dentinal tubules. The abraded surface with the CVD bur suggested a removal process in layers. The laser-irradiated surface showed a rough aspect with opened tubules and the absence of a smear layer. The results of this study suggest that a high-speed diamond bur, ultrasound, and laser were able to perform cavity preparation. However, the CVD bur presented a higher surface quality. 相似文献
103.
This paper proposes the use of a simplified analytical model to evaluate acoustic conditions in restaurant dining rooms required for ensuring the intelligibility of conversations. The model is useful for design applications and is suitable for evaluating the maximum number of speakers present in a restaurant room in order to ensure intelligibility of conversations taking place at each table in the presence of background noise caused by conversations at other tables. The maximum number of speakers is studied in relation to the sound level difference between useful and disturbing sound, sound absorption of the room, and the average speaker–listener distance. The model is applied to the case of a dining hall in a multipurpose centre, which is currently in the planning stage. 相似文献
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105.
Giordano Lesma Severo Salvadori Francesco Airaghi Engin Bojnik Anna Borsodi Teresa Recca Alessandro Sacchetti Gianfranco Balboni Alessandra Silvani 《Molecular diversity》2013,17(1):19-31
This study reports on new pharmacologically active endomorphin-2 analogues, incorporating β 2-hPhe, β 3-hPhe and β 3-hTic unnatural amino acids in the place of the Phe3–Phe4residues. Such α, β-hybrid analogues were designed to exploit the great potential of β-amino acids in generating conformational variation at the key positions 3 and 4, with the aim of evaluating the effect on the opioid binding affinity. Ligand-stimulated binding assays indicated that some analogues retained a significant affinity, especially for the δ receptor. 1H NMR and molecular modelling suggested the predominance of bent structures for all compounds. The molecular docking with the μ-opioid receptor model was also performed, highlighting a common binding mode for active compounds and helping to rationalize the observed structure–activity data. 相似文献
106.
L Di Bari G Pescitelli C Pratelli D Pini P Salvadori 《The Journal of organic chemistry》2001,66(14):4819-4825
The method employing dimolybdenum tetraacetate for the assignment of the absolute configuration of optically active 1,2-diols is thoroughly revisited and applied to several compounds, some of which were synthesized by asymmetric cis-dihydroxylation. No exceptions were found to the empirical rule relating the sign of the induced CD spectrum and the configuration of the substrate, whatever its structure and sterical requirements. To broaden the scope of the method, its applicability to critical situations commonly encountered with synthetic products is tested. It is demonstrated that the method can be applied on samples with low chemical and optical purity, and that it may lend itself as a means to estimate the ee. The roles of the water content of the sample and of the diol-to-dimolybdenum ratio are investigated. 相似文献
107.
Vozzi G Rechichi A Dini F Salvadori C Vozzi F Burchielli S Carlucci F Arispici M Ciardelli G Giusti P Ahluwalia A 《Macromolecular bioscience》2008,8(1):60-68
Polymeric scaffolds were realised with linear degradable PU in the form of square, hexagonal and octagonal grids. They were characterised in terms of their mechanical properties. Analysis shows that the mechanical properties of the scaffolds depend on their geometries which are easily modulated using PAM. In vitro biological assays showed that PU promotes the adhesion and proliferation of fibroblast cells and that cell activities are better on PU scaffolds than on PU films. In vivo implantation of PU and PLGA scaffolds and PU films demonstrated that the scaffolds are completely resorbed after three months with a slight inflammatory response, while the PU film was still present after six months with an intense granulomatous reaction. 相似文献
108.
The Rh4(CO)12 catalysed reaction with CO and H2 of 1-phenyl- and 3-phenyl allylamine gives 5-phenyl- and 3-phenyl-2-pyrrolidinone respectively, in good yield. A reasonable reaction pathway of the carbonylation reaction is presented. 相似文献
109.
Moreira RF Salvadori MC Azevedo CP Oliveira-Silva D Borges DC Moreno RA Sverdloff CE Borges NC 《Biomedical chromatography : BMC》2010,24(11):1220-1227
The validation of a high throughput and specific method using a high‐performance liquid chromatography coupled to electrospray (ES+) ionization tandem triple quadrupole mass spectrometric (LC‐ESI‐MS/MS) method for ondansetron quantification in human plasma is described. Human plasma samples were extracted by liquid–liquid extraction (LLE) using methyl tert‐butyl ether and analyzed by LC‐ESI‐MS/MS. The limit of quantification was 0.2 ng/mL and the method was linear in the range 0.2–60 ng/mL. The intra‐assay precisions ranged from 1.6 to 7.7%, while inter‐assay precisions ranged from 2.1 to 5.1%. The intra‐assay accuracies ranged from 97.5 to 108.2%, and the inter‐assay accuracies ranged from 97.3 to 107.0%. The analytical method was applied to evaluate the relative bioavailability of two pharmaceutical formulations containing 8 mg of ondansetron each in 25 healthy volunteers using a randomized, two‐period crossover design. The geometric mean and respective 90% confidence interval (CI) of ondansetron test/reference percent ratios were 90.15% (81.74–99.44%) for Cmax and 93.11% (83.01–104.43%) for AUC0–t. Based on the 90% confidence interval of the individual ratios (test formulation/reference formulation) for Cmax and AUC0‐inf, it was concluded that the test formulation is bioequivalent to the reference one with respect to the rate and extent of absorption of ondansetron. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
110.