In this study, a specific technique was used to quickly, easily, and single step, synthesize core-shell magnetite-silica nanoparticles by controlling the reaction conditions using the proper surfactant. In the first step, the magnetite nanoparticles were prepared by co-precipitation method and silica shell was immediately formed by the sol-gel process. Synthesis was performed at 80?°C with stirring at 12,000?rpm in an alkaline medium. The structural and morphological characteristics of core-shell nanoparticles were examined by XRD, TEM, SEM, and BET analyses. In addition, vibrating sample magnetometer (VSM) was used to evaluate the magnetic characteristics. XRD analysis confirmed the existence of both magnetite and silica phases in the final structure. TEM images showed the presence of nanocomposite particles with core-shell structure of 25?nm diameter. The mean core and shell size were estimated to be about 20 and 2.5?nm, respectively. A study of the magnetic characteristics showed super-paramagnetic behavior with 60?emu/g saturation magnetization (Ms). Due to the high ratio of core size to shell thickness, the magnetic saturation for the synthetized core-shell nanoparticles in this research was significant. In comparison to other multi-step synthesis techniques, the results obtained from this research confirmed the formation of magnetite-silica core-shell structures with the desired magnetic behavior in a quick and single-step process.
This paper explains how with the help of nano titania-supported sulfonic acid (n-TSA), new 1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives can be produced. To do this, at first n-TSA, which is relatively cheap, easy separable and reusable was made. Next, using this nano catalyst,1,8-dioxo-octahydroxanthene and tetrahydrobenzo[b]pyran derivatives were synthesized from di-ketones and various aromatic aldehydes/or malononitrile without using solvent. Appropriate one-pot operation using different aromatic aldehydes with both electron donating and withdrawing groups have resulted in the best yields. Reusability of the nano catalyst, environmental friendliness, reduced reaction time, non-toxic reaction medium and catalyst high activity are substantial advantages of this work. Nowadays, it is really important that the catalyst can be recovered easily and reused five times while maintaining catalytic activity. 相似文献
Local state transformation is the problem of transforming an arbitrary number of copies of a bipartite resource state to a bipartite target state under local operations. That is, given two bipartite states, is it possible to transform an arbitrary number of copies of one of them into one copy of the other state under local operations only? This problem is a hard one in general since we assume that the number of copies of the resource state is arbitrarily large. In this paper we prove some bounds on this problem using the hypercontractivity properties of some super-operators corresponding to bipartite states. We measure hypercontractivity in terms of both the usual super-operator norms as well as completely bounded norms. 相似文献
We demonstrate a method to use phase-modulated pumps for multicasting of return-to-zero differential phase-shift keying (RZ-DPSK) signals. The method uses phase modulation of the input signal along with the co-phase-modulated pumps prior to wavelength conversion. Nine copies of a 50?Gbit/s RZ-DPSK data signal are generated via four-wave mixing with an average conversion efficiency of ~0?dB. An average receiver sensitivity penalty of ~1.9?dB is observed at a bit-error rate of 10(-9) with a worst case of 2.3?dB. The effects of synchronization errors and phase-modulation frequencies up to 5?GHz are investigated. 相似文献
We study the problem of maximizing constrained non-monotone submodular functions and provide approximation algorithms that improve existing algorithms in terms of either the approximation factor or simplicity. Different constraints that we study are exact cardinality and multiple knapsack constraints for which we achieve (0.25−?)-factor algorithms.We also show, as our main contribution, how to use the continuous greedy process for non-monotone functions and, as a result, obtain a 0.13-factor approximation algorithm for maximization over any solvable down-monotone polytope. 相似文献
A simple approach involving refluxing appropriately disubstituted thiosemicarbazide 8 in presence of formic acid for the synthesis of 1, a potent azole antifungal agent, has been described. 相似文献
On the line of a previous work on the spectral properties of some of heteroaryl chalcone, the effect of medium acidity and photoreactivity of 3‐(4‐dimethylamino‐phenyl)‐1‐(2,5‐dimethyl‐thiophen‐3‐yl)‐propenone (DDTP) has been investigated in dimethylformamide and in chloromethane solvents such as methylenechloride, chloroform and carbon tetrachloride. The dye solution (ca. 5×10−4 mol·L−1 in DMF) gives a good laser emission in the range 470–560 nm with emission maximum at 515 nm upon pumping by nitrogen laser (λex=337.1 nm). The laser parameters such as gain coefficient (α), emission cross section (δe) and half life energy (E1/2) at maximum laser emission are also determined. 相似文献
Alzheimer’s disease (AD) is a primary cause of dementia in ageing population affecting more than 35 million people around the globe. It is a chronic neurodegenerative disease caused by defected folding and aggregation of amyloid beta (Aβ) protein. Aβ is formed by the cleavage of membrane embedded amyloid precursor protein (APP) by using enzyme ‘transmembrane aspartyl protease, β-secretase’. Inhibition of β-secretase is a viable strategy to prevent neurotoxicity in AD. Another strategy in the treatment of AD is inhibition of acetylcholinesterase. This inhibition reduces the degradation of acetylcholine and temporarily restores the cholinergic function of neurons and improves cognitive function. Monoamine oxidase and higher glutamate levels are also found to be linked with Aβ peptide related oxidative stress. Oxidative stress leads to reduced activity of glutamate synthase resulting in significantly higher level of glutamate in brain. The aim of this study is to perform in silico screening of a virtual library of biaryl scaffold containing compounds potentially used for the treatment of AD. Screening was done against the primary targets of AD therapeutics, acetylcholinesterase, β-secretase (BACE1), Monoamine oxidases (MAO) and N-Methyl-D-aspartate (NMDA) receptor. Compounds were screened for their inhibitory potential by employing molecular docking approach using AutoDock vina. Binding energy scores were embodied in the heatmap to display varies strengths of interactions of the ligands targeting AD.
Results
Several ligands showed notable interaction with at least two targets, but the strong interaction with all the targets is shown by very few ligands. The pharmacokinetics of the interacting ligands was also predicted. The interacting ligands have good drug-likeness and brain availability essential for drugs with intracranial targets.
Conclusion
These results suggest that biaryl scaffold may be pliable to drug development for neuroprotection in AD and that the synthesis of further analogues to optimize these properties should be considered.