Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer

Kahweol and cafestol are two diterpenes extracted from Coffea arabica beans that have distinct biological activities. Recent research describes their potential activities, which include anti-inflammatory, anti-diabetic, and anti-cancer properties, among others. The two diterpenes have been shown to have anticancer effects in various in vitro and in vivo cancer models. This review aims to shed light on the recent developments regarding the potential effects of kahweol and cafestol on various cancers. A systematic literature search through Google Scholar and PubMed was performed between February and May 2022 to collect updates about the potential effects of cafestol and kahweol on different cancers in in vitro and in vivo models. The search terms “Kahweol and Cancer” and “Cafestol and Cancer” were used in this literature review as keywords; the findings demonstrated that kahweol and cafestol exhibit diverse effects on different cancers in in vitro and in vivo models, showing pro-apoptotic, cytotoxic, anti-proliferative, and anti-migratory properties. In conclusion, the diterpenes kahweol and cafestol display significant anticancer effects, while remarkably unaffecting normal cells. Our results show that both kahweol and cafestol exert their actions on various cancers via inducing apoptosis and inhibiting cell growth. Additionally, kahweol acts by inhibiting cell migration.     

Distributional analysis for discontinuous fields

The jump conditions that hold across singular surfaces for the fields having step function discontinuities do not, in general, apply if these surfaces themselves carry concentrated fields. In this note, the general situation when the surfaces of discontinuity carry multilayers and deform as they propagate is discussed. Formulas are presented for the first and second derivatives for these multilayers.     

Oxidation studies on Andrographolide

Jones oxidation of Andrographolide (1), gave mixture of three products (3-dehydroandrographolide (5), 3,19-bis dehydroandrographolide (6) and 19-dehydroandrographolide (7). Tritylation of andrographolide at C19-OH resulted to products 8 and diene 9, which can be converted to its acetate 10 and oxidation product 11.     

Synthesis of macrosphelides with a thiazole side chain: new antitumor candidates having apoptosis-inducing property

Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides having a 16-membered skeleton, were designed and synthesized using a ring-closing metathesis (RCM) strategy. Some of these hybrids were found to exhibit notable apoptosis-inducing activity against human lymphoma cells with higher potency than parent natural macrosphelides, and to be a promising lead compound for development of a new antitumor agent.     

Essential Spectra, Matrix Operator and Applications

This paper gives a survey on some recent results on the spectral theory of block operator matrices. We study the closeness in the product space and we give some conditions to characterize the essential spectra in the Browder resolvent set case. Furthermore, we apply the obtained results to several models such as delay equations, Sturm–Liouville problem and transport equations.     

Moment expansion analysis for time-domain asymptotics

We apply our recently developed distributional technique [2, 3] to study time-domain asymptotics. This enables us to present a rigorous mathematical discussion and extensions of the results given by Chapman [1] and subsequent workers in this field. The present analysis is facilitated by defining functions which are distributionally small at infinity. We find that one of the advantages of using this technique is that multidimensional extensions can be derived very easily. © 1998 B. G. Teubner Stuttgart–John Wiley & Sons Ltd.     

Cosmological analysis of reconstructed $${\mathcal {F}}(T,T_{\mathcal {G}})$$ models

In this paper, we analyze cosmological consequences of the reconstructed generalized ghost pilgrim dark energy \({\mathcal {F}}(T,T_{\mathcal {G}})\) models in terms of redshift parameter z. For this purpose, we consider power-law scale factor, scale factor for two unified phases and intermediate scale factor. We discuss graphical behavior of the reconstructed models and examine their stability analysis. Also, we explore the behavior of equation of state as well as deceleration parameters and \(\omega _{\Lambda }-\omega _{\Lambda }^{'}\) as well as \(r-s\) planes. It is found that all models are stable for pilgrim dark energy parameter 2. The equation of state parameter satisfies the necessary condition for pilgrim dark energy phenomenon for all scale factors. All other cosmological parameters show great consistency with the current behavior of the universe.