Enoxacin, levofloxacin, and gatifloxacin represent one of the most important prerogative scaffolds in drug development. They possess broad spectrum antimicrobial and anti-inflammatory activities. They inhibit bacterial growth by blocking their topoisomerase enzyme which is necessary for the proper functioning of bacterial DNA. In this article, we have reviewed the synthetic approaches involved in the synthesis of derivatives of enoxacin, levofloxacin, and gatifloxacin. 相似文献
The charged current pion production induced by neutrinos in12C,16O and56Fe nuclei has been studied. The calculations have been done for the coherent as well as the incoherent processes assuming
Δ dominance and takes into account the effect of Pauli blocking, Fermi motion and the renormalization of Δ in the nuclear
medium. The pion absorption effects have also been taken into account 相似文献
Research on Chemical Intermediates - The electrical conductivity of biodegradable polymeric scaffolds has shown promising results in tissue engineering, particularly for electrically excitable... 相似文献
ZnO nanocrystalline films have been prepared on Si(1 0 0) substrate using direct current (D.C) magnetron sputtering technique at room temperature. The thickness of nanocrystalline films almost linearly increased with deposition duration and the sizes of crystalline grains almost kept unchanged. After deposition, thermal annealing was performed at 800 °C in atmosphere for 2 h in order to improve the qualities of ZnO thin films. Scanning electron microscope (SEM) images showed the surface roughness of the films less than 45 nm. X-ray diffraction (XRD) patterns revealed the slight evolution of the crystal structures. Raman scattering spectra confirmed the data obtained from X-ray diffraction measurements.With these ZnO nanocrystalline films, prototypic gas sensors were fabricated. Both sensitivity and response of the sensors to different gases (H2 and CH4) were investigated. A quick response of time, less than 1 second to CH4 gas sensor has been achieved. 相似文献
Dandelion-like gallium nitride (GaN) microstructures were successfully synthesized via Ni catalyst assisted chemical vapor deposition method at 1200 °C under NH3 atmosphere by pre-treating precursors with aqueous ammonia. The as-synthesized product was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). X-ray diffraction analysis revealed that as-synthesized dandelion-like GaN was pure and has hexagonal wurtzite structure. SEM results showed that the size of the dandelion-like GaN structure was in the range of 30-60 μm. Dandelion-like GaN microstructures exhibited reasonable field emission properties with the turn-on field of 9.65 V μm−1 (0.01 mA cm−2) and threshold field of 11.35 V μm−1 (1 mA cm−2) which is sufficient for applications of electron emission devices, field emission displays and vacuum micro electronic devices. Optical properties were studied at room temperature by using fluorescence spectrophotometer. Photoluminescence (PL) measurements of dandelion-like GaN showed a strong near-band-edge emission at 370.2 nm (3.35 eV) with blue band emission at 450.4 nm (2.75 eV) and 465.2 nm (2.66 eV) but with out yellow band emission. The room-temperature photoluminescence properties showed that it has also potential application in light-emitting devices. The tentative growth mechanism for the growth of dandelion-like GaN was also described. 相似文献
We predict waterflood displacement on a pore-by-pore basis using pore network modelling. The pore structure is captured by a high-resolution image. We then use an energy balance applied to images of the displacement to assign an average contact angle, and then modify the local pore-scale contact angles in the model about this mean to match the observed displacement sequence. Two waterflooding experiments on oil-wet rocks are analysed where the displacement sequence was imaged using time-resolved synchrotron imaging. In both cases the capillary pressure in the model matches the experimentally obtained values derived from the measured interfacial curvature. We then predict relative permeability for the full saturation range. Using the optimised contact angles distributed randomly in space has little effect on the predicted capillary pressures and relative permeabilities, indicating that spatial correlation in wettability is not significant in these oil-wet samples. The calibrated model can be used to predict properties outside the range of conditions considered in the experiment.
A fast digital-analog control polarization-based optical scanner with complete three-dimensional beam-forming programmability is described. Its features include low power consumption and large-aperture liquid-crystal-based optics, digital repeatability, and time-multiplexed accurate analog beam forming. Analog frequency and amplitude control of the nematic liquid-crystal beam-former cells permits continuous fine-scan programmability over a 0.66-mrad horizontal deflection, a 0.75 mrad vertical deflection, and an infinity-to-1.84-m focal-length longitudinal scan. First demonstrations included an 8-point volumetric scan and a 2-bit digital lens scan, both at 1310 nm, with a 35-micros random-access time. 相似文献