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61.
A. Mushtaq S. Ali M. Iqbal S. Shahzadi M. N. Tahir H. Ismail 《Russian Journal of Coordination Chemistry》2018,44(3):187-197
Two new complexes of substituted phenyl acetic acids with CuSO4 · 5H2O and 2,2′-bipyridine (Bipy) with formula [CuL(Bipy)2]L · nH2O, where L = 2-ClC6H4CH2COO– (I), 2-CH3-3-NO2C6H3CH2COO– (II) and n = 3 (I); 4 (II), have been synthesized. These complexes have been characterized by elemental analysis, FT-IR and X-ray crystal diffraction (CIF file CCDC nos. 1487707 (I), 1487708 (II)). Both complexes are mononuclear and crystallize in the triclinic space group P1?. In both complexes two molecules of Bipy bind equatorially with metal atom and one molecule of substituted phenyl acetic acid binds at axial position giving rise to a distorted five coordinated geometry around copper atom, while the second oxygen atom of carboxylate ligand appears to occupy the sixth position resulting in highly distorted six coordination environments around metal center in both complexes. However, another molecule of substituted phenyl acetic acid along with water molecules lies as co-crystal within the crystal lattice. Two bipyridine molecules in both complexes are lying in different planes and are oriented at dihedral angle of 63.89(8)° and 74.99(11)° in complexes I and II, respectively. Extensive hydrogen bonding because of water molecules present in crystal lattice plays a vital role in the formation of the 3D structure. Additionally, other weak interactions such as π–π interactions markedly influence the supramolecular structure. An investigation of DNA binding ability of both complexes using UV-visible spectroscopy and anti-diabetic capacity is also presented. Results revealed that synthesized complexes bind with SSDNA through intercalation as well as groove binding mode with Kb values of 2.45 × 104 and 7.72 × 103 M–1 for complex I and II, respectively. Complex II strongly inhibits in-vitro α-glucosidase with IC50 value of 30.4 μM, while complex I moderately inhibits in-vitro α-amylase with IC50 value of 69.9 μM. Acarbose was employed as standard in both assays. 相似文献
62.
Complexes of lauric acid with general formula M(L)2 · xH2O (M = Cu, Co, Ni, Mn) and M(L)2 (M = Zn, Hg) where L = (CH3(CH2)10COOH) have been synthesized. Their elemental analyses show the good agreement between calculated and experimental values.
These complexes have been characterized by spectroscopic techniques, such as IR, UV-visible, atomic absorption, and mass spectrometry,
which show that the carboxylate group acts as bidentate in the solid state. Kinetic parameters, such as the order of reaction,
activation energy, enthalpy, and entropy were calculated using the Coats and Horowitz methods. The calculated values are in
a good agreement with the observed TG values that confirm the structural integrity of the complexes. These complexes were screened for their in vitro biological
activities against different bacteria and fungi to establish their significance.
The article was submitted by the authors in English. 相似文献
63.
Taiba Naseem Fozia Bibi Saira Arif Muhammad Waseem Sirajul Haq Mohamad Nor Azra Taavi Liblik Ivar Zekker 《Molecules (Basel, Switzerland)》2022,27(21)
In this work, graphene oxide (GO) and its reduced graphene oxide-zinc oxide nanocomposite (rGO-ZnO) was used for the removal of Cr (VI) from aqueous medium. By employing a variety of characterization techniques, morphological and structural properties of the adsorbents were determined. The adsorption study was done by varying concentration, temperature, pH, time, and amount of adsorbent. The results obtained confirmed that rGO-ZnO is a more economical and promising adsorbent for removing Cr (VI) as compared to GO. Kinetic study was also performed, which suggested that sorption of Cr (VI) follows the pseudo-first-order model. For equilibrium study, non-linear Langmuir was found a better fitted model than its linearized form. The maximum adsorption capacity calculated for GO and rGO-ZnO nanocomposite were 19.49 mg/g and 25.45 mg/g, respectively. Endothermic and spontaneous nature of adsorption was detected with positive values of ΔS (change in entropy), which reflects the structural changes happening at the liquid/solid interface. 相似文献
64.
The new organotin(IV) complexes with 4-({[(E)-(2-hydroxyphenyl)methylidene]amino}methyl)cyclohexane carboxylic acid (HL, Schiff base) were synthesized by the reaction of di- and triorganotin salts in the presence of triethylamine as base or dioctyltin oxide using Dean and Stark trap for the removal of azeotropic water. All complexes were characterized by elemental analysis, IR, NMR (1H and 13C) and mass spectrometry. The IR data indicate that in both di- and triorganotin(IV) carboxylates, the ligand moiety -COO acts as a bidentate group in solid state. Multinuclear NMR data show that triorganotin complexes exhibit the four-coordinated geometry, while diorganotin(IV) complexes show the coordination number greater than four, probably five or six, in solution state. These compounds were screened for antibacterial activities against six pathogenic bacterial strains. The activities were measured in terms of inhibition zones (mm). Antifungal activity was determined against six pathogenic fungal strains, cytotoxicity by the brine shrimp lethality assay. Results for antibacterial and antifungal activity, and cytotoxicity of these compounds demonstrate that complexes exhibit significant biological activity with few exceptions. 相似文献
65.
Syeda Shahzadi Batool Quratulain Syed Muhammad Salman Haider 《Journal of Coordination Chemistry》2018,71(9):1380-1391
The syntheses, characterization, and crystal structures of the reaction products of Cu2+ with imidazole (Himz) and different aromatic carboxylates, viz.: [Cu(Himz)2(cinn)2(H2O)] (1), [Cu(Himz)2(paba)2] (2) and [Cu(Himz)2(clba)2] (3) (cinn– = C9H7O2–, paba– = C7H6NO2–, clba– = C7H4ClO2–) are described and studied by spectroscopic (UV–visible, FTIR) measurements. Single-crystal X-ray diffraction analyses indicate that each complex is monomeric. The metal ion in 1 adopts square-pyramidal coordination geometry arising from two imidazole nitrogens, two cinnamate oxygens, and an apical aqua. The metal ions of 2 and 3, however, assume a square planar configuration, which is realized by coordination of two nitrogens of two imidazoles and two oxygens; in both complexes, the imidazole moieties are trans to each other. TGA results indicate that upon heating, these complexes lose their carboxylate anions first, followed by removal of the imidazole molecules. 相似文献
66.
Saira?Hameed Koji?Ikegami Eiji?Sugiyama Shoko?Matsushita Yoshishige?Kimura Takahiro?Hayasaka Yuki?Sugiura Noritaka?Masaki Michihiko?Waki Isao?Ohta Md?Amir?Hossen Mitsutoshi?SetouEmail author 《Analytical and bioanalytical chemistry》2015,407(25):7589-7602
A protocol for the direct analysis of the phospholipid composition in the whole body of adult soil nematode, Caenorhabditis elegans (C. elegans), was developed, which combined freeze-cracking of the exoskeletal cuticle and matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). Biomolecules in the m/z range from 700 to 900 were more effectively detected in the freeze-cracked than from simple frozen adult nematode bodies. Different distribution of biomolecules was observed in a nematode body when the matrix was applied with a sublimation deposition method. The whole-body IMS technique was applied on genetically deficient mutant C. elegans to combine whole-body lipidomics and genetics, by comparing the fatty acid compositions, especially of the phosphatidylcholine (PC) species, between the wild-type and fat-1 mutants, which lack the gene encoding an n-3 fatty acid desaturase. A significant reduction of PC(20:5/20:5) and PC(20:4/20:5) and a marked increase of PC(20:4/20:4), PC(20:3/20:4), and PC(20:3/20:3) were detected in the fat-1 mutants in positive ion mode. In addition, phospholipid compositions other than PCs were analyzed in negative ion mode. A loss of a possible phosphatidylinositol (PI) with 18:0/20:5 and a compensative accumulation of putative PI(18:0/20:4) were detected in the fat-1 mutants. In conclusion, the whole-body MALDI-IMS technique is useful for the profiling of multiple biomolecules in C. elegans in both intra- and inter-individual levels. 相似文献
67.
A simple procedure for a clean and high‐yielding oxidative deoximation of benzaldoximes and ketoximes using a silica‐gel‐supported chromic acid reagent has been developed. This solid‐supported reagent allows us to carry out this reaction in nonaqueous dichloromethane reaction media. 相似文献
68.
M. Jabeen S. Ali S. Shahzadi M. Shahid Q. M. Khan S. K. Sharma K. Qanungo 《Journal of the Iranian Chemical Society》2012,9(3):307-320
Homobimetallic complexes with oxygen and sulphur donor ligand have been synthesized at room temperature under stirring conditions using R2SnCl2 (R?=?Me, n-Bu) and R3SnCl (R?=?Me, n-Bu, Ph) in 1:1 molar ratio. The synthesized complexes have been characterized by elemental analysis, IR and multinuclear NMR (1H, 13C) spectroscopy. These complexes have also been screened for their biological activities. IR data show that the ligand acts in a bidentate manner and exhibits trigonal bipyramidal geometry in solid state which is also confirmed by semi-empirical study. NMR data show that reported complexes exhibit tetrahedral geometry in solution. Results of antimicrobial screening activities indicated that complexes (6) and (7) are very effective antibacterial and antifungal agents, respectively, and they might indeed be a potential source of antimicrobial agents, while the complex (3) exhibits significant free radical scavenging ability with lower IC50 value of 99.47?±?1.2???g/mL. Results of cytotoxicity/haemolytic activity showed the significant value of % haemolysis for complex (7) (18.101?±?2.3), while complex (4) was found to be least cytotoxic (5.733?±?1.0). Only a few colonies are observed in mutagenicity testing by Ames test. 相似文献
69.
N. Tabassam S. Ali S. Shahzadi M. Shahid M. Abbas Q. M. Khan S. K. Sharma K. Qanungo 《Russian Journal of General Chemistry》2013,83(12):2423-2437
Seven different organotin(IV) complexes have been synthesized by reacting 2-ethylanilinocarbonylpropenoic acid with R2SnCl2/R3SnCl under reflux conditions. The organotin(IV) complexes along with ligand have been characterized by different techniques including elemental analysis, FT-IR and multinuclear NMR (1H and 13C). IR data show that complexation occurs through -COO site and the ligand is bidentate which is also confirmed by the semi-empirical quantum-mechanical study. 1H and 13C NMR data confirm the tetrahedral geometry of complexes in solution. The complexes as well as the ligand were also checked for various 相似文献
70.
Basit Muhammad Abdul Tariq Zeeshan Zahid Saira Khan Sheheryar Siddiqui Farrukh Arsalan Khan Muhammad Farooq Ali Gohar Park Tae Joo 《Journal of Cluster Science》2022,33(6):2443-2454
Journal of Cluster Science - Successive ionic layer adsorption and reaction (SILAR) process has been diversely used for deposition of various metal chalcogenides. SnS is one of them. Owing to the... 相似文献