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排序方式: 共有647条查询结果,搜索用时 15 毫秒
641.
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Johanna Busch Thomas Niemann Jan Neumann Peter Stange Sabrina Gärtner Tristan Youngs Sarah Youngs Dr. Dietmar Paschek Dr. Ralf Ludwig 《Chemphyschem》2023,24(12):e202300031
Defects fundamentally govern the properties of all real materials. Correlating molecular defects to macroscopic quantities remains a challenge, particularly in the liquid phase. Herein, we report the influence of hydrogen bonds (HB) acting as defects in mixtures of non-hydroxyl-functionalized ionic liquids (ILs) with an increasing concentration of hydroxyl-functionalized ILs. We observed two types of HB defects: The conventional HBs between cation and anion (c–a), and the elusive HBs between cations (c–c) despite the repulsive Coulomb forces. We use neutron diffraction with isotopic substitution in combination with molecular dynamics simulations for measuring the geometry, strength, and distribution of mobile OH defects in the IL mixtures. In principle, this procedure allows relating the number and stability of defects to macroscopic properties such as diffusion, viscosity, and conductivity, which are of utmost importance for the performance of electrolytes in batteries and other electrical devices. 相似文献
643.
Dr. Sabrina Heng Dr. Xiaozhou Zhang Dr. Jinxin Pei Dr. Alaknanda Adwal Dr. Philipp Reineck Prof. Brant C. Gibson Prof. Mark R. Hutchinson Prof. Andrew D. Abell 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(3):854-862
A new spiropyran-based stimuli-responsive delivery system is fabricated. It encapsulates and then releases an extraneous compound in response to elevated levels of Zn2+, a critical factor in cell apoptosis. A C12-alkyl substituent on the spiropyran promotes self-assembly into a micelle-like nanocarrier in aqueous media, with nanoprecipitation and encapsulation of added payload. Zn2+ binding occurs to an appended bis(2-pyridylmethyl)amine group at biologically relevant micromolar concentration. This leads to switching of the spiropyran (SP) isomer to the strongly fluorescent ring opened merocyanine-Zn2+ (MC-Zn2+) complex, with associated expansion of the nanocarriers to release the encapsulated payload. Payload release is demonstrated in solution and in HEK293 cells by encapsulation of a blue fluorophore, 7-hydroxycoumarin, and monitoring its release using fluorescence spectroscopy and microscopy. Furthermore, the use of the nanocarriers to deliver a caspase inhibitor, Azure B, into apoptotic cells in response to an elevated Zn2+ concentration is demonstrated. This then inhibits intracellular caspase activity, as evidenced by confocal microscopy and in real-time by time-lapsed microscopy. Finally, the nanocarriers are shown to release an encapsulated proteasome inhibitor ( 5 ) in Zn2+-treated breast carcinoma cell line models. This then inhibits intracellular proteasome and induces cytotoxicity to the carcinoma cells. 相似文献
644.
Dr. Marta Perez-Lloret Dr. Aurore Fraix Dr. Salvatore Petralia Dr. Sabrina Conoci Dr. Virginie Tafani Dr. Giovanna Cutrone Prof. Antonio Vargas-Berenguel Dr. Ruxandra Gref Prof. Salvatore Sortino 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(64):14638-14643
A simple and green synthetic protocol for the rapid and effective preparation of Ag, Au and Au@Ag core–shell nanoparticles (NPs) is reported based on the light irradiation of a biocompatible, water-soluble dextran functionalized with benzophenone (BP) in the presence of AgNO3, HAuCl4, or both. Photoactivation of the BP moiety produces the highly reducing ketyl radicals through fast (<50 ns) intramolecular H-abstraction from the dextran scaffold, which, in turn, ensures excellent dispersibility of the obtained metal NPs in water. The antibacterial activity of the AgNPs and the photothermal action of the Au@Ag core–shell are also shown. 相似文献
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This paper shows how FTIR-ATR microscopy can be used to monitor the distribution of components in polymeric membranes without the need for extensive sample preparation. The validity of the technique is proven using a different technique, namely ESEM. Three examples of its use are given; a drug in a pharmaceutical tablet, a biocide in a PVC formulation and a defect on a polymer coated metal. 相似文献
647.
Gianfranco Pacchioni Sabrina Sicolo Cristiana Di Valentin Mario Chiesa Elio Giamello 《ChemInform》2008,39(44):no-no
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option. 相似文献