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排序方式: 共有628条查询结果,搜索用时 447 毫秒
491.
492.
Dr. Albert A. Smith Emelyne M. Pacull Sabrina Stecher Prof. Dr. Peter W. Hildebrand Dr. Alexander Vogel Prof. Dr. Daniel Huster 《Angewandte Chemie (International ed. in English)》2023,62(35):e202383561
G protein-coupled receptors initiate signal transduction in response to ligand binding. Growth hormone secretagogue receptor (GHSR), the focus of this study, binds the 28 residue peptide ghrelin. While structures of GHSR in different states of activation are available, dynamics within each state have not been investigated in depth. We analyze long molecular dynamics simulation trajectories using “detectors” to compare dynamics of the apo and ghrelin-bound states yielding timescale-specific amplitudes of motion. We identify differences in dynamics between apo and ghrelin-bound GHSR in the extracellular loop 2 and transmembrane helices 5–7. NMR of the GHSR histidine residues reveals chemical shift differences in these regions. We evaluate timescale specific correlation of motions between residues of ghrelin and GHSR, where binding yields a high degree of correlation for the first 8 ghrelin residues, but less correlation for the helical end. Finally, we investigate the traverse of GHSR over a rugged energy landscape via principal component analysis. 相似文献
493.
We report density functional theory calculations on the interaction of Pd atoms and small Pd clusters with an electron-rich MgO surface. This surface can be generated by forming a specific kind of defects, named (H+)(e−) centers, using well known chemical recipes. By deposition of gas-phase Pd atoms on the properly functionalized MgO surface, one can generate collections of small Pd cluster anions with peculiar chemical properties. The (H+)(e−) centers act as nucleation sites for diffusing Pd atoms and favor the formation of small, thermally stable clusters. The presence of an extra charge on the metal cluster results in a large vibrational red-shift of adsorbed CO molecules. The present results intend to stimulate experimental work to produce stable metal cluster anions on the surface of an ionic oxide. 相似文献
494.
Ogg RJ Zou P Allen DN Hutchins SB Dutkiewicz RM Mulhern RK 《Magnetic resonance imaging》2008,26(4):504-512
Functional magnetic resonance imaging (fMRI) was performed in 30 healthy adults to identify the location, magnitude, and extent of activation in brain regions that are engaged during the performance of Conners' Continuous Performance Test (CPT). Performance on the task during fMRI was highly correlated with performance on the standard Conners' CPT in the behavioral testing laboratory. An extensive neural network was activated during the task that included the frontal, cingulate, parietal, temporal, and occipital cortices; the cerebellum and the basal ganglia. There was also a network of brain regions which were more active during fixation than task. The magnitude of activation in several regions was correlated with reaction time. Among regions that were more active during task, the overall volume of supratentorial activation and cerebellar activation was greater in the left hemisphere. Frontal activation was greater in dorsal than in ventral regions, and dorsal frontal activation was bilateral. Ventral frontal region and parietal lobe activation were greater in the right hemisphere. The volume of clusters of activation in the extrastriate ventral visual pathway was greater in the left hemisphere. This network is consistent with existing models of motor control, visual object processing and attentional control and may serve as a basis for hypothesis-driven fMRI studies in clinical populations with deficits in Conners' CPT performance. 相似文献
495.
Valeria Poggetti Silvia Salerno Emma Baglini Elisabetta Barresi Federico Da Settimo Sabrina Taliani 《Molecules (Basel, Switzerland)》2022,27(8)
Carbonic anhydrases (CAs) are a family of ubiquitous metal enzymes catalyzing the reversible conversion of CO2 and H2O to HCO3− with the release of a proton. They play an important role in pH regulation and in the balance of body fluids and are involved in several functions such as homeostasis regulation and cellular respiration. For these reasons, they have been studied as targets for the development of agents for treating several pathologies. CA inhibitors have been used in therapy for a long time, especially as diuretics and for the treatment of glaucoma, and are being investigated for application in other pathologies including obesity, cancer, and epilepsy. On the contrary, CAs activators are still poorly studied. They are proposed to act as additional (other than histidine) proton shuttles in the rate-limiting step of the CA catalytic cycle, which is the generation of the active hydroxylated enzyme. Recent studies highlight the involvement of CAs activation in brain processes essential for the transmission of neuronal signals, suggesting CAs activation might represent a potential therapeutic approach for the treatment of Alzheimer’s disease and other conditions characterized by memory impairment and cognitive problems. Actually, some compounds able to activate CAs have been identified and proposed to potentially resolve problems related to neurodegeneration. This review reports on the primary literature regarding the potential of CA activators for treating neurodegeneration-related diseases. 相似文献
496.
Antonio Da Settimo Giampaolo Primofiore Federico Da Settimo Francesca Simorini Anna Maria Marini Concettina La Motta Sabrina Taliani 《Journal of heterocyclic chemistry》2000,37(2):373-377
The preparation of a novel purine containing heterocyclic ring system, indolotriazinopurine, by the condensation of 8‐hydrazinotheophylline with 5‐substituted isatins via the intermediate hemiaminal and hydrazone derivatives, is described. 相似文献
497.
Francesco A. Bottino Antonino Pollicino Gaetano Alberghina Sabrina Di Giorgi Salvatore Fisichella 《Macromolecular rapid communications》1998,19(11):553-556
Paper was preserved by deposition of poly(cyclohexene oxide) polymerised in situ by a photoinitiated cationic process. The efficiency of the deposition, as function of parameters such as the used catalytic system and the reaction time, has been evaluated by detection of uncovered cellulose present at the sample surface determined by means of X-ray photoelectron spectroscopy. The percentage of uncovered cellulose detected was ranging from 1 to 40%. 相似文献
498.
Luce Micaela Mattio Cecilia Pinna Giorgia Catinella Loana Musso Kasandra Juliet Pedersen Karen Angeliki Krogfelt Sabrina Dallavalle Andrea Pinto 《Molecules (Basel, Switzerland)》2021,26(24)
The natural stilbenoid dehydro-δ-viniferin, containing a benzofuran core, has been recently identified as a promising antimicrobial agent. To define the structural elements relevant to its activity, we modified the styryl moiety, appended at C5 of the benzofuran ring. In this paper, we report the construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed us to prepare a focused collection of dehydro-δ-viniferin analogues. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analogue 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4 µg/mL). 相似文献
499.
Giorgio Montaudo Sabrina Carroccio Maurizio S. Montaudo Concetto Puglisi Filippo Samperi 《Macromolecular Symposia》2004,218(1):101-112
Matrix-Assisted Laser Desorption/Ionization (MALDI) allows the identification of repeat units and end groups, the structural analysis of linear and cyclic oligomers, and the estimate of composition and sequence for copolymers. MALDI has also been applied to the measurement of molar mass distributions in polymers and to the study of thermal and oxidative processes in polymers. This paper illustrates the detection of self-association in macromolecules made by coupling MALDI and Size Exclusion Chromatography (SEC), the investigation of polymer oxidation phenomena, and the characterization of copolymers formed in the processing of reactive polymer blends. 相似文献
500.
Maria-Beatrice Coltelli Sabrina Bianchi Stefania Savi Vincenzo Liuzzo Mauro Aglietto 《Macromolecular Symposia》2003,204(1):227-236
Reactive blending of 70/30 by weight PET/polyolefin (PO) mixtures was carried out in a discontinuous mixer using a polyolefin functionalized with dialkyl maleates and potential transesterification catalysts to improve the formation of graft PO-PET copolymers. The yield of this reaction was evaluated by the analysis of FT-IR spectra of blends residual fraction after selective extractions of unreacted polyester. The building of a calibration curve and the analysis of the spectra by deconvolution was performed to evaluate the percentage of grafted PET. The results are discussed in terms of influence of the different catalysts and of polyolefin structure on the blends morphology. 相似文献