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291.
Sonntag LS Schweizer S Ochsenfeld C Wennemers H 《Journal of the American Chemical Society》2006,128(45):14697-14703
The "azido gauche effect" was examined both experimentally and theoretically and was found to determine the conformation of, for example, (4R)- and (4S)-azidoproline (Azp) derivatives. For (4R)Azp derivatives, the azido gauche effect induces a preferred C(4)-exo conformation of the pyrrolidine ring, which leads to stabilization of the s-trans amide conformer of, e.g., Ac-(4R)Azp-OCH(3) (5R) via an n-->pi interaction between the nonbonding electrons of the oxygen of the acetyl group and the carbonyl group of the ester. For (4S)Azp derivatives, the azido gauche effect results in a C(4)-endo conformation of the pyrrolidine ring that does not allow for this stabilizing n-->pi interaction of the s-trans conformer. Consequently, a significantly higher s-trans:s-cis amide conformer ratio is observed for (4R)Azp compared to (4S)Azp derivatives (e.g., 6.1:1 versus 2.6:1 in D(2)O for Ac-(4R)Azp-OCH(3) (5R) compared to Ac-(4S)Azp-OCH(3) (5S)). These conformational preferences are reflected in the higher tendency of (4S)Azp-containing peptides to form cyclic peptides with all-cis amide bonds compared to (4R)Azp derivatives. Ab initio calculations demonstrate that the strength of the azido gauche effect is comparable to that of the well-known "fluorine gauche effect". For azidoethane derivatives N(3)-CH(2)CH(2)-X (X = N(3), NHCOH, NHAc, or N(CH(3))Ac), the ab initio calculations revealed energy differences of 5-13 kJ mol(-)(1) between the anti and gauche conformations in favor of the gauche conformer. Calculations were also performed for the (4R)Azp and (4S)Azp derivatives 5R and 5S, supporting the experimentally observed data. 相似文献
292.
We report here on the fabrication and characterization of stable thin films of amorphous silica (SiO(x)) deposited on glass slides coated with a 5 nm adhesion layer of titanium and 50 nm of gold, using the plasma-enhanced chemical vapor deposition (PECVD) technique. The resulting surfaces were characterized using atomic force microscopy (AFM), ellipsometry, contact angle measurements, and surface plasmon resonance (SPR). AFM analysis indicates that homogeneous films of silica with low roughness were formed on the gold surface. The deposited silica films showed excellent stability in different solvents and in piranha solution. There was no significant variation in the thickness or in the SPR signal after these harsh treatments. The Au/SiO(x) interfaces were investigated for their potential applications as new surface plasmon resonance sensor chips. Silica films with thicknesses up to 40 nm allowed visualization of the surface plasmon effect, while thicker films resulted in the loss of the SPR characteristics. SPR allowed further the determination of the silica thickness and was compared to ellipsometric results. Chemical treatment of the SiO(x) film with piranha solution led to the generation of silanol surface groups that have been coupled with a trichlorosilane. 相似文献
293.
The chemistry of the surface functional groups of picocyanobacteria Synechococcus PCC 7942 cells was examined as a function of H+ and calcium concentrations. Titration experiments, infrared spectroscopy, biosorption experiments, and chemical modeling were used to gain insight into the mechanisms of biosorption. The pKa and concentration of active sites on the cell wall were clarified with the aid of potentiometric titration. Modeling calculations and infrared spectra are consistent with pKa's values of 4.3, 5.2, 6.9, 9.1, and 10.0 and a total concentration of 7.8 x 10(-4) mol g(-1). Spectral analysis of an aqueous cellular suspension revealed a presence of carboxyl, amide, phosphate, hydroxyl, and carbohydrate moieties. Correspondence between spectral data and potentiometric titration curves supported the hypothesis that carboxylate groups and phosphodiester groups mediate calcium adsorption to bacterial cells. This process is strongly pH dependent. In the second part of the experimental work, Synechococcus cells were suspended in the presence of different calcium concentrations. Mechanistic modeling demonstrated that the calcium adsorption phenomenon can be described taking into account only two mechanisms: ion exchange and complexation. 相似文献
294.
Szunerits S Coffinier Y Janel S Boukherroub R 《Langmuir : the ACS journal of surfaces and colloids》2006,22(25):10716-10722
This article reports chemical stability studies of a gold film electrode coated with thin silicon oxide (SiOx) layers using electrochemical, surface plasmon resonance (SPR) and atomic force microscopy (AFM) techniques. Silica films with different thicknesses (d = 6.4, 9.7, 14.5, and 18.5 nm) were deposited using a plasma-enhanced chemical vapor deposition technique (PECVD). For SiOx films with d >/= 18.5 nm, the electrochemical behavior is characteristic of a highly efficient barrier for a redox probe. SiOx films with thicknesses between 9.5 and 14.5 nm were found to be less efficient barriers for electron transfer. The Au/SiOx interface with 6.4 nm of SiOx, however, showed an enhanced steady-state current compared to that of the other films. The stability of this interface in solutions of different pH was investigated. Whereas a strongly basic solution led to a continuous dissolution of the SiOx interface, acidic treatment produced a more reticulated SiOx film and improved electrochemical behavior. The electrochemical results were corroborated by SPR measurements in real time and AFM studies. 相似文献
295.
Cramer N Buchweitz M Laschat S Frey W Baro A Mathieu D Richter C Schwalbe H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(9):2488-2503
Cylindramide (1) was built up from three components: a hydroxyornithine derivative 7, a tetrazolylsulfone 8, and a substituted pentalene subunit 9. Derivative 7 was prepared in a six-step reaction sequence involving the Wittig reaction and a Sharpless asymmetric dihydroxylation starting from N-Boc-3-aminopropanal (12). Tetrazolylsulfone 8 was accessible in four steps from dioxinone 22. The synthesis of the pentalene fragment 9 started from cycloocta-1,5-diene 26, that was converted into enantiopure bicyclo[3.3.0]octanedione 29. The latter was functionalized to give derivative 9. The total synthesis was accomplished by inducing C-C bond formation by Sonogashira coupling of derivatives 9 and 7 followed by olefination with tetrazolylsulfone 8 under Julia-Kocienski conditions, macrocyclization, and subsequent Lacey-Dieckmann condensation to form the tetramic acid unit. As indicated by extensive 1H and 13C NMR spectroscopic investigations (DQF-COSY, ROESY spectra), the stereochemistry of synthetic cylindramide (1) corresponds with that of the naturally occurring product. ROE data were used for molecular modeling of the lowest-energy structures for cylindramide. 相似文献
296.
Highly crystalline single-phase nanoparticles of the important thermoelectric materials Zn4Sb3 and ZnSb were prepared from solvochemically activated powders of elemental zinc and elemental antimony. Low-temperature reactions with reaction temperatures of 275-300 degrees C were applied using an excess of elemental zinc. The nanoscale thermoelectrics obtained were characterized by X-ray powder diffraction, transmission electron microscopy, and thermal analysis. nc-Zn4Sb3 showed particle sizes of 50-70 nm, whereas particle sizes of 15-20 nm were observed for nc-ZnSb. Calorimetric investigations showed an increased heat capacity, Cp, for nc-Zn4Sb3 with respect to the bulk material which could be reduced to the bulk value by annealing nc-Zn4Sb3 at 190 degrees C. Interestingly, nc-Zn4Sb3 showed exothermic decomposition into zinc-poorer ZnSn at 196 degrees C in an open system, indicating that Zn4Sb3 is metastable in nanocrystalline form at room temperature. 相似文献
297.
A numerical approach for the topological optimization of 3D linear elastic problems using boundary elements and the topological derivative is presented in this work. (© 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
298.
Azra ulovi Franko Bur
ul Vedrana ike uli Mirko Ru
i Petra Brzovi Sabine Montaut Patrick Rollin Ivica Blaevi 《Molecules (Basel, Switzerland)》2021,26(17)
Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products-isothiocyanates (ITCs) using GC-MS analysis. Thirteen GSLs were identified with arylaliphatic as the major ones in the following order: 3-hydroxybenzyl GSL (glucolepigramin, 7), benzyl GSL (glucotropaeolin, 9), 3,4,5-trimethoxybenzyl GSL (11), 3-methoxybenzyl GSL (glucolimnanthin, 12), 4-hydroxy-3,5-dimethoxybenzyl GSL (3,5-dimethoxysinalbin, 8), 4-hydroxybenzyl GSL (glucosinalbin, 6), 3,4-dimethoxybenzyl GSL (10) and 2-phenylethyl GSL (gluconasturtiin, 13). GSL breakdown products obtained by hydrodistillation (HD) and CH2Cl2 extraction after hydrolysis by myrosinase for 24 h (EXT) as well as benzyl ITC were tested for their cytotoxic activity using MTT assay. Generally, EXT showed noticeable antiproliferative activity against human bladder cancer cell line UM-UC-3 and human glioblastoma cell line LN229, and can be considered as moderately active, while IC50 of benzyl ITC was 12.3 μg/mL, which can be considered as highly active. 相似文献
299.
Inductively coupled plasma mass spectrometry (ICP-MS) and laser ablation ICP-MS (LA-ICP-MS) have been applied as the most important inorganic mass spectrometric techniques having multielemental capability for the characterization of solid samples in materials science. ICP-MS is used for the sensitive determination of trace and ultratrace elements in digested solutions of solid samples or of process chemicals (ultrapure water, acids and organic solutions) for the semiconductor industry with detection limits down to sub-picogram per liter levels. Whereas ICP-MS on solid samples (e.g. high-purity ceramics) sometimes requires time-consuming sample preparation for its application in materials science, and the risk of contamination is a serious drawback, a fast, direct determination of trace elements in solid materials without any sample preparation by LA-ICP-MS is possible. The detection limits for the direct analysis of solid samples by LA-ICP-MS have been determined for many elements down to the nanogram per gram range. A deterioration of detection limits was observed for elements where interferences with polyatomic ions occur. The inherent interference problem can often be solved by applying a double-focusing sector field mass spectrometer at higher mass resolution or by collision-induced reactions of polyatomic ions with a collision gas using an ICP-MS fitted with collision cell. The main problem of LA-ICP-MS is quantification if no suitable standard reference materials with a similar matrix composition are available. The calibration problem in LA-ICP-MS can be solved using on-line solution-based calibration, and different procedures, such as external calibration and standard addition, have been discussed with respect to their application in materials science. The application of isotope dilution in solution-based calibration for trace metal determination in small amounts of noble metals has been developed as a new calibration strategy. This review discusses new analytical developments and possible applications of ICP-MS and LA-ICP-MS for the quantitative determination of trace elements and in surface analysis for materials science. 相似文献
300.
Jahn S Lohmann W Bomke S Baumann A Karst U 《Analytical and bioanalytical chemistry》2012,402(1):461-471
In the present study, a method for the analysis of reactive metabolites via liquid chromatography (LC) with inductively coupled
plasma–mass spectrometry (MS) was developed. A ferrocenyl-modified glutathione (GSH) reagent, consisting of GSH and succinimidyl-3-ferrocenylpropionate,
was synthesized. Derivatization of the tripeptide was performed at the N-terminus, leaving the nucleophilic thiol group vacant
for the attack of electrophilic compounds. The potential of ferrocenylpropionate (FP)-GSH as a trapping agent for reactive
metabolites was investigated using an electrochemical flow-through cell for metabolism simulation coupled online to a LC system
with electrospray ionization mass spectrometric detection. The pharmaceuticals amodiaquine, an antimalarial agent, and clozapine,
an antipsychotic compound, served as model substances. By proving the successful adduct formation between the reactive metabolite
and ferrocene-labeled GSH, it could be shown that FP-GSH is an effective trapping agent which eases routine reversed-phase
LC analyses. In contrast to GSH, which is usually used for the conjugation of reactive metabolites and where the resulting
adducts often show no or only very little retention, FP-GSH facilitates the detection of the corresponding metabolite adducts
due to higher retention times. 相似文献