Synthesis,characterization, and biological evaluation of new copper complexes of naphthyl pyrazole ligands

Two naphthalene pyrazole ligands were synthesized using KOH/DMSO and Cu catalyst and characterized with FT-IR, ESI-MS, ¹H, and ¹³C NMR spectroscopies. The crystal structures of 1-(2-methylnaphthalen-1-yl)-1H-pyrazole (MeNap-Pz) ligand have been determined with X-ray crystal structure analysis. Reaction of the ligands with Cu(NO₃)₂x3.5H₂O gave two new complexes and characterized with magnetic susceptibility, molar conductance, FT-IR, LCMS-MS, ICP-OES, NMR, thermogravimetric analysis, and ESR spectra. The spectral data of the ligands are coordinated to the metal ion through the nitrogen atoms of the pyrazole ring. Consequently, it has been determined that [Cu(MeNap-Pz)₂(NO₃)]NO₃.2H₂O complex showed square planar geometry and [Cu(NapMe-Pz)₂(NO₃)₂].H₂O complex showed octahedral geometry. All compounds were screened for in vitro antibacterial activity and copper complexes have been shown to be effective on bacteria.     

PHOTODYNAMIC ACTION OF MEROCYANINE 540 IN ARTIFICIAL BILAYERS AND NATURAL MEMBRANES: ACTION SPECTRA AND QUANTUM YIELDS

The action spectra and quantum yields for singlet oxygen (1O2) generation by merocyanine 540 (MC540) in liposomes and isolated erythrocyte membranes were obtained using electron spin resonance techniques. Oxygen consumption was measured by spin label oximetry in the presence of histidine for fully-saturated dimyristoylphosphatidylcholine vesicles, mono-unsaturated 1-palmitoyl-2-oleoylphosphatidylcholine vesicles and erythrocyte membranes. The quantum yield for the photogeneration of 1O2 by membrane-bound MC540 in aqueous buffer was determined to be 0.065 +/- 0.005, which is approx. 1/10 of the value determined for Rose Bengal under similar conditions. Using unilamellar liposomes and isolated erythrocyte membranes containing MC540 at different monomer/dimer ratios, we have observed that the action spectra of 1O2 generation closely overlap the absorption spectra of the monomeric dye in these systems. It is likely that factors which affect the monomer-dimer equilibrium of MC540 will influence the production of 1O2. These findings have important implications for the phototherapeutic efficacy of MC540.     

Linearly polarized intracavity passive Q-switched Yb-doped photonic crystal fibre laser

In this paper we report linearly polarized high average power passive Q-switched ytterbium-doped photonic crystal fibre laser with a Cr⁴⁺:YAG crystal as a saturable absorber. An average output power of 9.4 W with pulse duration of 64 ns and pulse repetition rate of 57.4 kHz with a slope efficiency of 52% was achieved. Measured polarization extinction ratio (PER) of the Q-switched laser output was 10.5 dB.     

Coherent oscillations of holes in GaAs0.86P0.14/Al0.7Ga0.3As surface quantum well

We show that in a GaAs_0.86P_0.14/Al_0.7Ga_0.3As near-surface quantum well, there is coherent oscillation of holes observed in time-resolved reflectivity signal when the top barrier of the quantum well is sufficiently thin. The quantum well states interact with the surface states under the influence of the surface electric field. The time period of the observed oscillation is 120±10 fs.     

Performance of Dispersion-Compensated Optical Transmission Systems Based on Different Electrical Drivers

In this article, the simulation results have been presented for dispersive optical communication with different electrical drivers. The length of single-mode fiber has been put in a run that is compensated by dispersion-compensated fiber. The results have been presented and it is observed that of all the electrical drivers, the NRZ rectangular is best suited for dispersive optical communication systems. For this electrical driver, the parameters like BER remain constant and low. For other drivers, the BER decreases more for RZ super-Gaussian. Similarly, the Q factor increases with runs for all types of drivers except for NRZ rectangular, for which it decreases. For all the drivers, it is clear that as the runs are varied, the eye opening penalty increases, that is, there is less eye opening as the length of single-mode fiber is increased. It is also seen that the dispersion-compensated fiber compensates for the dispersion very effectively irrespective of the type of driver. Of the two formats, return to zero (RZ) and non-return to zero (NRZ), the earlier has more eye-opening penalty as the distortion is more and is clearly visible in all the rectangular, super-Gaussian, and raised cosine RZ formats. Of the three RZ formats, it is observed that RZ rectangular has the least eye-opening penalty. The non-return to zero format has less distortion and, of the two rectangular and raised cosine, the NRZ rectangular has less eye-opening penalty.     

Systematic study of multiparticle production in nucleus–nucleus interactions at 14.6 A GeV

An experimental analysis of 855 events induced by 14.6 A GeV ²⁸Si in nuclear emulsion is presented. Mean multiplicities of charged secondary particles produced in the nuclear interactions are studied and compared with the results from the other experiments for the same projectile at 3.7 A GeV as well as data for proton at similar energy (14 GeV). An analysis of pseudorapidity densities of target fragments (black and grey particles) is also performed. The behaviour of the KNO scaling law of the multiplicity distribution for shower particles has been examined. In order to accumulate knowledge about the intermittent behaviour of shower particles, the scaled factorial moments (SFMs) are computed in η-space and ?-space for a set of data in the ²⁸Si–AgBr events. Furthermore, validity of limiting fragmentation of shower particles produced in central collision events induced by ²⁸Si-emulsion interactions has been tested. A crude estimation for the energy density of the nuclear matter formed in the central collision events at our energy has been examined.     

硫酸存在时N-溴代苯二甲酰亚胺对甘露糖的胶束催化氧化

The kinetics of micellar-catalyzed oxidation of mannose by N-bromophthalimide was studied in the presence of sulfuric acid at 313 K. The orders of reaction with respect to [mannose], [oxidant], and [H+] were found to be fractional, first, and negative fractional order, respectively. Anionic micelles of sodiumdodecyl sulfate showed a partial inhibitory effect, while cationic micelles of cetyltrimethylammonium bromide increased the reaction rate with the same kinetic behavior. The reaction was catalyzed by cationic micelles, because of favorable electrostatic/thermodynamic/hydrophobic/hydrogen bonding between reactants and cationic micelles. Their catalytic roles are best explained by Berezin’s model. A variation of [phthalimide] showed that the rate of reaction decreased with increasing [phthalimide]. It was observed that, an increase of [mercuric acetate] had no effect on reaction velocity. The influence of salts on the reaction rate was also studied. The rate constant (kW ), binding constants (KS+KO), and corresponding activation parameters (Ea, ⊿H#, ⊿S#, and ⊿G#) were determined. A detailed mechanism with associated reaction kinetics is presented and discussed.     

Mixing and phase separation in molecular fluid mixtures

The equation of state for a hard convex body (HCB) fluid mixture, which is based on the scaled particle theory, is utilized to derive the Helmholtz free energy, F, and the concentration fluctuations, S.,(O), to investigate the thermodynamic stability of athermal and not athermal molecular fluid mixtures. The role of the size and the non-sphericity geometrical factor of the molecule on the stability of the mixture is critically examined. The energetics of long-range attractive forces for not athermal mixtures have been introduced through the double Yukawa potential in conjunction with a realistic distribution function. The formalism allows one to investigate the properties of molecular mixtures under induced conditions of extreme temperature and pressure. The results suggest that geometrical factors coupled with energetics play a dominant role in phase separation.     

Temporal dynamics of high repetition rate pulsed single longitudinal mode dye laser

Theoretical and experimental studies of temporal dynamics of grazing incidence grating (GIG) cavity, single-mode dye laser pumped by high repetition rate copper vapour laser (CVL) are presented. Spectral chirp of the dye laser as they evolve in the cavity due to transient phase dynamics of the amplifier gain medium is studied. Effect of grating efficiency, focal spot size, pump power and other cavity parameters on the temporal behaviour of narrow band dye laser such as build-up time, pulse shape and pulse width is studied using the four level dye laser rate equation and photon evolution equation. These results are compared with experimental observations of GIG single-mode dye laser cavity. The effect of pulse stretching of CVL pump pulse on the temporal dynamics of the dye laser is studied.