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731.
Yoshikawa K Kokudo N Tanaka M Nakano T Shibata H Aragaki N Higuchi T Hashimoto T 《Chemical & pharmaceutical bulletin》2008,56(1):89-92
From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). 相似文献
732.
Yamada K Tanabe K Miyamoto T Kusumoto T Inagaki M Higuchi R 《Chemical & pharmaceutical bulletin》2008,56(5):734-737
A new monomethylated ganglioside, DSG-A (3), was obtained, together with four known gangliosides, compounds (1, 2, 4, 5), from the lipid fraction of the chloroform/methanol extract of the ovary of the sea urchin Diadema setosum. The structures of the new ganglioside was determined on the basis of chemical and spectroscopic evidence to be 1-O-[9-O-methyl-(N-acetyl-alpha-D-neuraminosyl)-(2-->6)-beta-D-glucopyranosyl]-ceramide (3). The ceramide moiety of 3 was composed of C18-phytosphingosine base, and 2-hydroxy and nonhydroxylated fatty acid units. These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor, in which compound 3 showed the most potent activity. 相似文献
733.
Horike S Hasegawa S Tanaka D Higuchi M Kitagawa S 《Chemical communications (Cambridge, England)》2008,(37):4436-4438
A robust extra-large microporous coordination polymer with a Kagomé type structure was synthesized by carboxylate/amine multifunctional ligand with a Cu(2+) cluster and the hexagonal 1D channels ( approximately 15 A) showed type I and IV adsorption isotherms for gas molecules. 相似文献
734.
Various substituted phenols were selectively synthesized by a one-pot reaction through the NHPI-catalyzed aerobic oxidation of 1,1-diarylethanes followed by treatment with dilute sulfuric acid. 相似文献
735.
736.
A highly stable nonbiofouling surface with well-packed grafted zwitterionic polysulfobetaine for plasma protein repulsion 总被引:1,自引:0,他引:1
Chang Y Liao SC Higuchi A Ruaan RC Chu CW Chen WY 《Langmuir : the ACS journal of surfaces and colloids》2008,24(10):5453-5458
An ideal nonbiofouling surface for biomedical applications requires both high-efficient antifouling characteristics in relation to biological components and long-term material stability from biological systems. In this study we demonstrate the performance and stability of an antifouling surface with grafted zwitterionic sulfobetaine methacrylate (SBMA). The SBMA was grafted from a bromide-covered gold surface via surface-initiated atom transfer radical polymerization to form well-packed polymer brushes. Plasma protein adsorption on poly(sulfobetaine methacrylate) (polySBMA) grafted surfaces was measured with a surface plasmon resonance sensor. It is revealed that an excellent stable nonbiofouling surface with grafted polySBMA can be performed with a cycling test of the adsorption of three model proteins in a wide range of various salt types, buffer compositions, solution pH levels, and temperatures. This work also demonstrates the adsorption of plasma proteins and the adhesion of platelets from human blood plasma on the polySBMA grafted surface. It was found that the polySBMA grafted surface effectively reduces the plasma protein adsorption from platelet-poor plasma solution to a level superior to that of adsorption on a surface terminated with tetra(ethylene glycol). The adhesion and activation of platelets from platelet-rich plasma solution were not observed on the polySBMA grafted surface. This work further concludes that a surface with good hemocompatibility can be achieved by the well-packed surface-grafted polySBMA brushes. 相似文献
737.
Kamoto M Umezawa N Kato N Higuchi T 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(26):8004-8012
The introduction of hexahistidine (His tag) is widely used as a tool for affinity purification of recombinant proteins, since the His tag binds selectively to nickel-nitrilotriacetic acid (Ni(2+)-NTA) complex. To develop efficient "turn-on" fluorescent probes for His-tagged proteins, we adopted a fluorophore displacement strategy, that is, we designed probes in which a hydroxycoumarin fluorophore is joined via a linker to a metal-NTA moiety, with which it forms a weak intramolecular complex, thereby quenching the fluorescence. In the presence of a His tag, with which the metal-NTA moiety binds strongly, the fluorophore is displaced, which results in a dramatic enhancement of fluorescence. We synthesized a series of hydroxycoumarins that were modified by various linkers with NTA (NTAC ligands), and investigated the chemical and photophysical properties of the free ligands and their metal complexes. From the viewpoint of fluorescence quenching, Ni(2+) and Co(2+) were the best metals. Fluorescence spectroscopy revealed a 1:1 binding stoichiometry for the Ni(2+) and Co(2+) complexes of NTACs in pH 7.4 aqueous buffer. As anticipated, these complexes showed weak intrinsic fluorescence, but addition of a His-tagged peptide (H-(His)(6)-Tyr-NH(2); Tyr was included to allow convenient concentration measurement) in pH 7.4 aqueous buffer resulted in up to a 22-fold increase in the fluorescence quantum yield. We found that the Co(2+) complexes showed superior properties. No fluorescence enhancement was seen in the presence of angiotensin I, which contains two nonadjacent histidine residues; this suggests that the probes are selective for the polyhistidine peptide. 相似文献
738.
Sakamoto R Kume S Nishihara H 《Chemistry (Weinheim an der Bergstrasse, Germany)》2008,14(23):6978-6986
Redox-active ferrocene- and triarylamine-terminated diethynylethene derivatives have been synthesized and their photochromic properties and switching behavior based on through-bond electronic communication between the two redox sites, as well as their emissions, have been examined. Both bis(ferrocenylethynyl)ethene 1 and bis(triarylaminoethynyl)ethene 2 show visible-light photochromism induced by donor-acceptor charge-transfer (CT) transitions from the ferrocene or triarylamine to the diethynylethene moieties. The reversibility and quantum yields of the photochromism of 2 (Phi(E-->Z)=6.1 x 10(-2), Phi(Z-->E)=1.4 x 10(-2)) are far higher than those of 1 (Phi(E-->Z)=8.6 x 10(-6), Phi(Z-->E)=2.5 x 10(-6)). The higher efficiency in 2 may be attributed to the absence of the heavy atom effect and of a low-lying (3)LF state, which are characteristic of ferrocenyl compounds. This proposition is further supported by the fact that bis(ferrocenylbuta-1,3-diynyl)ethene 3, which, unlike 1, is free from steric interference between the two ferrocenyl groups in the Z form, does not show a significant improvement in its photoisomerization quantum yields (Phi(E-->Z)=6.2x10(-5), Phi(Z-->E)=3.4 x 10(-5)). The visible-light photochromism of 1 and 2 is accompanied by a switch in the strength of the electronic communication between the two redox sites in their mixed-valence states (DeltaE(0)' values are 70 and 48 mV for (E)-1 and (Z)-1, and 74 and 63 mV for (E)-2 and (Z)-2). In the case of 2, further evaluations were carried out through intervalence charge-transfer (IVCT) band analyses and DFT calculations. We have also demonstrated that steric repulsion between the methyl ester moieties in the Z form is implicated in the reduction in the through-bond electronic communication. Compound 2 exhibits photoluminescence, which is more efficient in the E form than in the Z form, whereas 1 and 3 show no photoluminescence. 相似文献
739.
Neelakandha S. Mani Jyun-Hung Chen James P. Edwards Min Wu Penghui Chen Robert I. Higuchi 《Tetrahedron letters》2008,49(12):1903-1905
An efficient synthesis of the androgen receptor modulator (R)-4a having an 8H-[1,4]oxazino[2,3-f]quinolin-8-one skeleton is described. Synthesis of this ring system, not readily accessible by classical Knorr cyclization methodology, was accomplished by an ortho-metallation strategy. Thus, lithiation of a pivaloyl-protected 7-amino-3,4-dihydro-1,4-benzoxazine using n-butyllithium allowed the introduction of a trifluoroacetyl group regioselectively at the 8-position. Subsequent Wittig reaction and acid catalyzed cyclization afforded the desired 8H-[1,4]oxazino[2,3-f]quinolin-8-one (R)-4a in very good overall yield from the corresponding benzoxazine. 相似文献
740.
Ryota Shimotsukue Dr. Kohei Fujii Yu Sato Dr. Yuki Nagashima Prof. Dr. Ken Tanaka 《Angewandte Chemie (International ed. in English)》2023,62(16):e202301346
We have developed the Rh+/H8-binap-catalyzed chemo-, regio-, diastereo-, and enantioselective intermolecular [2+2+2] cycloaddition of three unsymmetric 2π components. Thus, two arylacetylenes react with a cis-enamide to yield a protected chiral cyclohexadienylamine. Moreover, replacing one arylacetylene with a silylacetylene enables the [2+2+2] cycloaddition of three distinct unsymmetric 2π components. These transformations proceed with excellent selectivity (complete regio- and diastereoselectivity and up to >99 % yield and >99 % ee). Mechanistic studies suggest the chemo- and regioselective formation of a rhodacyclopentadiene intermediate from the two terminal alkynes. 相似文献