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31.
A nonlinear problem for penetrant diffusion with relaxation in polymers is considered. A numerical approach to solving this type of problems is developed. The proposed numerical scheme based on a finite element domain approximation and a time difference method can be used for numerical simulation of the considered penetrant diffusion in 2-D and 3-D domains. A numerical procedure and a corresponding computer code are created and tested for some examples in 1-D and 2-D domains. 相似文献
32.
Design and synthesis of fluorescent shell functionalized polymer micelles for biomedical application
Selen R. Ismail Rayna G. Bryaskova Nikolai I. Georgiev Nikoleta D. Philipova Ventsislav V. Bakov Veselina P. Uzunova Rumiana D. Tzoneva Vladimir B. Bojinov 《先进技术聚合物》2020,31(6):1365-1376
pH‐sensitive polymers can be defined as polyelectrolytes that include in their structure weak acidic or basic groups that either accept or release protons in response to a change in the environmental pH. This work summarizes the design, synthesis, and potential applications of pH‐responsive fluorescent copolymers in the biomedical field. This was achieved using atom transfer radical polymerization (ATRP) of tert‐butyl acrylate using a CuBr/N,N,N′,N″N″‐pentamethyldiethylenetriamine catalyst system in conjunction with an alkyl bromide as the initiator. Well‐defined macroinitiators based on poly(tert‐butyl acrylate) with narrow molecular weight distributions were obtained by the addition of an appropriate solvent system in order to create a homogeneous catalytic system. The addition of n‐butyl acrylate as a second building block in order to create well‐defined poly(tert‐butyl acrylate)‐b‐poly(n‐butyl acrylate) block copolymers (PtBA‐b‐PnBA) followed by chemical modification of the block copolymers and functionalization with an appropriate fluorescent compound are the basis for the preparation of well‐defined fluorescent pH‐sensitive micelles. Thus, prepared water soluble nanosized pH‐sensitive micelles consisting of hydrophobic poly(n‐butyl acrylate) core and hydrophilic polyacrylic acid shell decorated with an appropriate fluorescent compound determined their potential applications of these systems in the field of biomedicine as biosensors, controlled drug delivery systems, and so on. In this respect, the cell viability and internalization of the polymer micelles were studied. 相似文献
33.
G. I. Smirnov L. M. Dimova A. A. Redchenko 《Russian Journal of Applied Chemistry》2004,77(8):1259-1262
Ion-exchange sorption of K+ and Na+ from their mixture on X-ray-amorphous and crystalline Sn(IV) hydrophosphates was studied. These sorbents exhibit a high selectivity for K+. Amorphous Sn(IV) hydrophosphate can be used for efficient purification of aqueous sodium salt solutions to remove potassium impurity.Translated from Zhurnal Prikladnoi Khimii, Vol. 77, No. 8, 2004, pp. 1275–1278.Original Russian Text Copyright © 2004 by Smirnov, Dimova, Redchenko. 相似文献
34.
R. Dimova U. Seifert B. Pouligny S. Förster H.-G. Döbereiner 《The European physical journal. E, Soft matter》2002,7(3):241-250
Giant vesicles prepared from the diblock copolymer polybutadien-b-polyethyleneoxide (PB-PEO) exhibit a shear surface viscosity,
which is about 500 times higher than those found in common phospholipid bilayers. Our result constitutes the first direct
measurement of the shear surface viscosity of such polymersomes. At the same time, we measure bending and stretching elastic
constants, which fall in the range of values typical for lipid membranes. Pulling out a tether from an immobilized polymersome
and following its relaxation back to the vesicle body provides an estimate of the viscous coupling between the two monolayers
composing the polymer membrane. The detected intermonolayer friction is about an order of magnitude higher than the characteristic
one for phospholipid membranes. Polymersomes are tough vesicles with a high lysis tension. This, together with their robust
rheological properties, makes them interesting candidates for a number of technological applications.
Received 2 March 2001 and Received in final form 15 February 2002 相似文献
35.
M. N. Achasov K. I. Beloborodov A. V. Berdyugin A. G. Bogdanchikov A. V. Bozhenok A. D. Bukin D. A. Bukin S. V. Burdin A. A. Valishev A. V. Vasil’ev V. B. Golubev T. V. Dimova V. P. Druzhinin P. M. Ivanov V. N. Ivanchenko A. A. Korol’ S. V. Koshuba A. A. Mamutkin A. V. Otboev E. V. Pakhtusova A. A. Sal’nikov S. I. Serednyakov V. A. Sidorov Z. K. Silagadze A. N. Skrinskii A. G. Skripkin V. V. Sharyi Yu. M. Shatunov 《JETP Letters》2002,75(9):449-451
The measurement of the ? → π0 e + e ? conversion decay probability on the SND detector at the VEPP-2M e + e ? collider gave the value Br(? → π 0 e + e ?) = (1.01 ± 0.28 ± 0.29) × 10?5. 相似文献
36.
The present study describes a simultaneous and highly reproducible large-scale synthesis of six (and more) colors of size-homogeneous and highly luminescent CdSe quantum dots in a single reaction, controlled by a slow-increasing temperature gradient. The described protocol allows a precise control and a synchronized isolation of aliquots of CdSe nanocrystals with defined sizes, avoiding disturbance of the growth of nanocrystals (existing in the reaction mixture) to the isolation of the next aliquot. The obtained quantum dot fractions are of high quality (in 95% size-homogeneous) and have sharp photoluminescence spectra (fwhm approximately 30 nm), quantum yields of 45-70% (in organic solvent), and a lack of aggregation in organic solvents. The method is environmentally friendly as it ensures almost complete utilization of the precursors and productive yield approximately 95%. 相似文献
37.
We describe a facile method to simultaneously measure the bending rigidity and capacitance of biomimetic lipid bilayers. Our approach utilizes the ellipsoidal deformation of quasi-spherical giant unilamellar vesicles induced by a uniform AC electric field. Vesicle shape depends on the electric field frequency and amplitude. Membrane bending rigidity can be obtained from the variation of the vesicle elongation on either field amplitude at fixed frequency or frequency at fixed field amplitude. Membrane capacitance is determined from the frequency at which the vesicle shape changes from prolate to oblate ellipsoid as the frequency is increased at a given field amplitude. 相似文献
38.
Computational scaffold hopping aims to identify core structure replacements in active compounds. To evaluate scaffold hopping potential from a principal point of view, regardless of the computational methods that are applied, a global analysis of conventional scaffolds in analog series from compound activity classes was carried out. The majority of analog series was found to contain multiple scaffolds, thus enabling the detection of intra-series scaffold hops among closely related compounds. More than 1000 activity classes were found to contain increasing proportions of multi-scaffold analog series. Thus, using such activity classes for scaffold hopping analysis is likely to overestimate the scaffold hopping (core structure replacement) potential of computational methods, due to an abundance of artificial scaffold hops that are possible within analog series. 相似文献
39.
Dimova D Wawer M Wassermann AM Bajorath J 《Journal of chemical information and modeling》2011,51(2):258-266
An activity landscape model of a compound data set can be rationalized as a graphical representation that integrates molecular similarity and potency relationships. Activity landscape representations of different design are utilized to aid in the analysis of structure-activity relationships and the selection of informative compounds. Activity landscape models reported thus far focus on a single target (i.e., a single biological activity) or at most two targets, giving rise to selectivity landscapes. For compounds active against more than two targets, landscapes representing multitarget activities are difficult to conceptualize and have not yet been reported. Herein, we present a first activity landscape design that integrates compound potency relationships across multiple targets in a formally consistent manner. These multitarget activity landscapes are based on a general activity cliff classification scheme and are visualized in graph representations, where activity cliffs are represented as edges. Furthermore, the contributions of individual compounds to structure-activity relationship discontinuity across multiple targets are monitored. The methodology has been applied to derive multitarget activity landscapes for compound data sets active against different target families. The resulting landscapes identify single-, dual-, and triple-target activity cliffs and reveal the presence of hierarchical cliff distributions. From these multitarget activity landscapes, compounds forming complex activity cliffs can be readily selected. 相似文献
40.
Binding of chitosan to phospholipid vesicles studied with isothermal titration calorimetry 总被引:1,自引:0,他引:1
We thermodynamically characterize the interaction of chitosan with small liposomes and the binding and organization of the polysaccharide on the membrane of the vesicles. By means of isothermal titration calorimetry (ITC), we obtain the enthalpy variations arising from binding of the positively ionized chitosan to neutral and negatively charged liposomes. The strong electrostatic interaction of the polysaccharide with the negative charges at the membrane gives rise to highly exothermic signal until charge compensation is reached. The equilibrium constant, the interaction stoichiometry, and the molar enthalpy of binding chitosan monomers to phospholipids from the external leaflet of the vesicle membrane are obtained from the isotherm curve fitting assuming independent binding sites. The strong exothermic signal indicates that the electrostatically driven binding of chitosan to the membrane is energetically favored, leading to further stabilization of the vesicle suspension. The higher the net negative charge of the vesicles, the more pronounced the adsorption of chitosan is, leading to weaker chain organization of the adsorbed chitosan at the membrane. At the point of charge saturation, vesicle aggregation takes place and we show that this behavior does not always lead to charge reversal at the membrane. Models for the binding behavior and structural organization of chitosan are proposed based on the experimental results from ITC, ζ-potential, and dynamic light scattering. 相似文献