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171.
Chiral chromanone lactones are a class of natural products with important biological activity. We report a direct diastereo- and enantioselective vinylogous conjugate addition of butenolide to 2-ester substituted chromones. The transformation proceeded well in the presence of as low as 1 mol% of a chiral N,N′-dioxide/ScIII complex, 3 Å MS and a catalytic amount of hexafluoroisopropanol (HFIP). The scope of Michael acceptors includes a variety of substituted chromones at different positions, and the desired chromanone lactones upon reduction are afforded in good yield and diastereoselectivity, and excellent enantioselectivity (up to 99% ee). The strategy could be used in the concise synthesis of blennolide C and gonytolide A, C and G.We report a direct, diastero- and enantioselective vinylogous 1,4-addition of butanolide to 2-ester chromones. A chiral ScIII complex enabled the reaction to proceed smoothly to give a variety of chraomanone lactones. 相似文献
172.
火焰原子吸收光谱法测定高血压患者头发中锌铜钙镁 总被引:4,自引:0,他引:4
用火焰原子吸收光谱法测定高血压患者45例及健康对照者34例头发中锌、铜、钙、镁的含量。结果表明,高血压患者头发中锌、铜、钙含量显著低于健康对照组(p〈0.05),镁含量极显著低于健康对照组,揭示体内锌、铜、钙、镁元素含量与高血压发病存在一定关系。 相似文献
173.
ZHANG Duan-Ming SUN Fan YU Bo-Ming PAN Gui-Jun SUN Hong-Zhang YIN Yan-Ping LI Rui SU Xiang-Ying 《理论物理通讯》2006,45(2):293-296
A simplified Olami-Feder-Christensen model on a random network has been studied. We propose a new toppling rule — when there is an unstable site toppling, the energy of the site is redistributed to its nearest neighbors randomly not averagely. The simulation results indicate that the model displays self-organized criticality when the system is conservative, and the avalanche size probability distribution of the system
obeys finite size scaling. When the system is nonconservative, the model
does not display scaling behavior. Simulation results of our model with
different nearest neighbors q is also compared, which indicates that the
spatial topology does not alter the critical behavior of the system. 相似文献
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177.
Optimization of Naringenin Nanoparticles to Improve the Antitussive Effects on Post-Infectious Cough
Zhengqi Dong Xiangtao Wang Mingyue Wang Rui Wang Zheng Meng Xiaotong Wang Bo Yu Meihua Han Yifei Guo 《Molecules (Basel, Switzerland)》2022,27(12)
Naringenin (NRG) is a natural compound with several biological activities; however, its bioavailability is limited owing to poor aqueous solubility. In this study, NRG nanoparticles (NPs) were prepared using the wet media milling method. To obtain NRG NPs with a small particle size and high drug-loading content, the preparation conditions, including stirring time, temperature, stirring speed, and milling media amount, were optimized. The NRG (30 mg) and D-α-tocopherol polyethylene glycol succinate (10 mg) were wet-milled in deionized water (2 mL) with 10 g of zirconia beads via stirring at 50 °C for 2 h at a stirring speed of 300 rpm. As a result, the NRG NPs, with sheet-like morphology and a diameter of approximately 182.2 nm, were successfully prepared. The NRG NPs were stable in the gastrointestinal system and were released effectively after entering the blood circulation. In vivo experiments indicated that the NRG NPs have good antitussive effects. The cough inhibition rate after the administration of the NRG NPs was 66.7%, cough frequency was three times lower, and the potential period was 1.8 times longer than that in the blank model group. In addition, the enzyme biomarkers and histological analysis results revealed that the NRG NPs can effectively regulate the inflammatory and oxidative stress response. In conclusion, the NRG NPs exhibited good oral bioavailability and promoted antitussive and anti-inflammatory effects. 相似文献
178.
Huan Wang Xinchen Liu Xiangyu Yan Jiawen Fan Daowei Li Jinsong Ren Xiaogang Qu 《Chemical science》2022,13(22):6704
Ultrasound (US)-mediated sonodynamic therapy (SDT) has emerged as a spatiotemporally controllable therapeutic modality in combating cancer because of its high tissue-penetration depth and minimal invasiveness. However, the elevated nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant program in cancer cells can serve as a chief reactive oxygen species (ROS) detoxification system to alleviate oxidative injury and promote tumorigenesis, and thus greatly antagonize the therapeutic efficacy of ROS-mediated anticancer therapies. Herein, we report that vanadium carbide MXene-derived carbon dots (PMQDs) can act as high-efficacy sonosensitizers to efficiently generate ROS upon US irradiation and simultaneously hinder the Nrf2 antioxidant program for enhanced sonodynamic therapy of cancer. These PMQDs show superior US-triggered ROS generating ability because of their efficient migration/separation of electron–hole pairs and narrow bandgap. Importantly, these PMQDs can serve as efficient redox homeostasis regulators to perturb the Nrf2 antioxidant mechanism and thus reduce its effects on ROS neutralization for enhanced SDT efficacy. Overall, the present study will not only provide a new paradigm to augment SDT by perturbing the Nrf2 antioxidant program, but also give valuable insights into developing high-efficacy MXene-derived nanoagents for cancer therapy.A redox homeostasis regulator has been developed as a high-efficacy sonosensitizer to efficiently generate reactive oxygen species upon ultrasound irradiation and simultaneously hinder the Nrf2 antioxidant program for enhanced sonodynamic therapy. 相似文献
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