61.
Currently,
188Re is obtained from
188W/
188Re chromatographic generator containing alumina which has a limited capacity (~80 mg Wg
?1) for
188W. This results in high bolus volumes of
188Re, which often needs to be concentrated before radiolabeling. We have demonstrated the feasibility of using polymer embedded nano crystalline titania (TiP), a novel high capacity sorbent material (~300 mg Wg
?1), for developing a
188W/
188Re chromatographic generator. A TiP based chromatographic
188W/
188Re generator was developed in which
188Re could be eluted with 0.9% saline solution. About 90% of the
188Re could be recovered in the first 4–5 mL of total activity with more than 80% yield. The purity of
188Re is adequate for clinical applications.
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