Multicomponent reactions for the synthesis of functionalized 1, 4-oxathiane-3-thiones under microwave irradiation in water

A series of substituted 1,4-oxathiane-3-thione derivatives were synthesized via one-pot multicomponent reactions of nitromethane, carbon disulfide and oxiranes in the presence of Et3N in water as the solvent under microwave irradiation. Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and straightforward procedure.     

Effcient synthesis of functionalized hydroindoles via catalyst-free multicomponent reactions of ninhydrin in water简

An efficient synthesis of hydroindeno[1,2-b]indoles is described via three-component reaction of ninhydrin and cycloalkan-1,3-dione in the presence of primary amines in water as the green solvent in excellent yield.     

Expeditious solvent-free synthesis of 1,3-thiazolanes via multicomponent reactions

A series of 1 3-thiazolane derivatives have been synthesized via multicomponent reactions of activated acetylenes,primary amines and isothiocyanates in the presence of a catalytic amount of Nmethylimidazole under solvent-free conditions.     

Multicomponent reactions of ammonium thiocyanate,acyl chlorides,alkyl bromides,and enaminones: A facile one-pot synthesis of thiophenes

An efficient synthesis of thiophene derivatives is described via one-pot reaction between ammonium thiocyanate, acyl chlorides, α-halocarbonyls, and enaminones under solvent-free conditions at 65 °C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.     

One-pot synthesis of coumarine derivatives using butylenebispyridinium hydrogen sulfate as novel ionic liquid catalyst

Pechmann condensation reaction of 3-hydroxyphenol and ethyl acetoacetate in the presence of 1,1′‐butylenebispyridinium hydrogen sulfate as an efficient, green, and recyclable catalyst produces 7-hydroxy-4-methylcoumarin in good yield under solvent-free conditions at room temperature. This catalyst has advantages such as the following: good to excellent yields, short reaction times, simplicity in operation, and easy workup procedure.     

Biosynthesis of Cu/KF/Clinoptilolite@MWCNTs nanocomposite and its application as a recyclable nanocatalyst for the synthesis of new Schiff base of benzoxazine derivatives and reduction of organic pollutants

Molecular Diversity - In this work, we synthesized new Schiff base of benzoxazine derivatives in excellent yields using multicomponent reactions of phthalaldehyde or its derivatives, primary...     

Novel isocyanide-based three-component synthesis of substituted 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in water

Three-component reaction of 1-(6-hydroxy-2-isopropenyl-1-benzofuran-yl)-1-ethanone, dialkyl acetylenedicarboxylates and isocyanides in water was described as efficient and green synthetic procedure for preparation of 9Hfuro[ 2,3-f]chromene-8,9-dicarboxylates in excellent yield. In these reactions, 1-(6-hydroxy-2-isopropenyl-1-benzofuranyl)- 1-ethanone was extracted from rhizomes of Petasites hybridus from northern Iran. The structure of this compound was determined by 1H, 13C-NMR and IR spectroscopy and confirmed by X-ray diffraction analysis. This procedure provides rapid access to novel and diversely substituted 9H-furo[2,3-f]chromene-8,9-dicarboxylate derivatives.