加速度环境下微槽流动与传热特性

航空电子设备在加速度环境下工作时,采用液体工质进行散热的电子设备的散热性能将受到加速度的影响。本文采用有限体积法对加速度环境下矩形微槽中体积浓度30%的乙二醇水溶液的流动和传热特性进行了系统研究。考察了加速度大小和方向对微槽中流动与传热特性的影响,以及加速度环境对不同微槽结构和工质流量下流动与传热特性的影响。研究表明,与不考虑加速度影响时相比,在开始的瞬间,微槽传热性能大幅降低,流动阻力系数急剧上升,     

基于SEM的我国重要城市现代化水平综合评价模型研究

基于结构方程(SEM)理论,以2008年统计数据为样本对影响城市现代化的测量指标进行了一阶、二阶验证性因素分析,得到了结构方程模型.并以测量指标在因子上的负荷、路径系数为基础构建权重,建立了城市现代化水平综合评价模型.对我国重要城市(直辖市、主要省会城市)现代化水平程度进行了相对评价,得到较为满意的结果.     

Harnessing Effective Molarity to Design an Electrochemical DNA-based Platform for Clinically Relevant Antibody Detection

Easy-to-use platforms for rapid antibody detection are likely to improve molecular diagnostics and immunotherapy monitoring. However, current technologies require multi-step, time-consuming procedures that limit their applicability in these fields. Herein, we demonstrate effective molarity-driven electrochemical DNA-based detection of target antibodies. We show a highly selective, signal-on DNA-based sensor that takes advantage of antibody-binding-induced increase of local concentration to detect clinically relevant antibodies in blood serum. The sensing platform is modular, rapid, and versatile and allows the detection of both IgG and IgE antibodies. We also demonstrate the possible use of this strategy for the monitoring of therapeutic monoclonal antibodies in body fluids. Our approach highlights the potential of harnessing effective molarity for the design of electrochemical sensing strategies.     

Isospectral orbifolds with different maximal isotropy orders

We construct pairs of compact Riemannian orbifolds which are isospectral for the Laplace operator on functions such that the maximal isotropy order of singular points in one of the orbifolds is higher than in the other. In one type of examples, isospectrality arises from a version of the famous Sunada theorem which also implies isospectrality on p-forms; here the orbifolds are quotients of certain compact normal homogeneous spaces. In another type of examples, the orbifolds are quotients of Euclidean and are shown to be isospectral on functions using dimension formulas for the eigenspaces developed in [12]. In the latter type of examples the orbifolds are not isospectral on 1-forms. Along the way we also give several additional examples of isospectral orbifolds which do not have maximal isotropy groups of different size but other interesting properties. All three authors were partially supported by DFG Sonderforschungsbereich 647.     

The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations

The translocator protein (TSPO) is a 18kDa transmembrane protein, ubiquitously present in human mitochondria. It is overexpressed in tumor cells and at the sites of neuroinflammation, thus representing an important biomarker, as well as a promising drug target. In mammalian TSPO, there are cholesterol–binding motifs, as well as a binding cavity able to accommodate different chemical compounds. Given the lack of structural information for the human protein, we built a model of human (h) TSPO in the apo state and in complex with PK11195, a molecule routinely used in positron emission tomography (PET) for imaging of neuroinflammatory sites. To better understand the interactions of PK11195 and cholesterol with this pharmacologically relevant protein, we ran molecular dynamics simulations of the apo and holo proteins embedded in a model membrane. We found that: (i) PK11195 stabilizes hTSPO structural fold; (ii) PK11195 might enter in the binding site through transmembrane helices I and II of hTSPO; (iii) PK11195 reduces the frequency of cholesterol binding to the lower, N–terminal part of hTSPO in the inner membrane leaflet, while this impact is less pronounced for the upper, C–terminal part in the outer membrane leaflet, where the ligand binding site is located; (iv) very interestingly, cholesterol most frequently binds simultaneously to the so-called CRAC and CARC regions in TM V in the free form (residues L150–X–Y152–X(3)–R156 and R135–X(2)–Y138–X(2)–L141, respectively). However, when the protein is in complex with PK11195, cholesterol binds equally frequently to the CRAC–resembling motif that we observed in TM I (residues L17–X(2)–F20–X(3)–R24) and to CRAC in TM V. We expect that the CRAC–like motif in TM I will be of interest in future experimental investigations. Thus, our MD simulations provide insight into the structural features of hTSPO and the previously unknown interplay between PK11195 and cholesterol interactions with this pharmacologically relevant protein.     

Further EPR-spin trapping studies of the photoinitiating activity of Irgacure 369

The radicals formed upon visible light irradiation of the photoinitiator 2-benzyl-2-dimethylamino-4′-morpholinobutyrophenone (Irgacure 369), 1, were investigated by means of EPR spectroscopy coupled with the spin trapping technique both in the absence and in the presence of a monomer. The results suggest a dual behavior of 1 that may act both as a Type I and a Type II photoinitiator. From experiments carried out in the presence of 2-ethoxythioxanthone (Pila 124), 2, an additive commonly used in combination with 1 as sensitizer, it is inferred that 2 mainly acts via hydrogen abstraction from 1.     

Flat manifolds isospectral on p-forms

We study isospectrality on p-forms of compact flat manifolds by using the equivariant spectrum of the Hodge-Laplacian on the torus. We give an explicit formula for the multiplicity of eigenvalues and a criterion for isospectrality. We construct a variety of new isospectral pairs, some of which are the first such examples in the context of compact Riemannian manifolds. For instance, we give pairs of flat manifolds of dimension n=2p, p≥2, not homeomorphic to each other, which are isospectral on p-forms but not on q-forms for q∈p, 0≤q≤n. Also, we give manifolds isospectral on p-forms if and only if p is odd, one of them orientable and the other not, and a pair of 0-isospectral flat manifolds, one of them Kähler, and the other not admitting any Kähler structure. We also construct pairs, M, M′ of dimension n≥6, which are isospectral on functions and such that β_p(M)<β_p(M’), for 04 and ? ₂ ² , respectively.     

Modeling the Evolution and Rupture of Pendular Liquid Bridges in the Presence of Large Wetting Hysteresis

A model has been developed to predict the shape evolution, rupture distance and postrupture liquid distribution of a pendular liquid bridge between two unequally sized spherical particles in the presence of wetting hysteresis. Two different simplifications of the bridge geometry were considered: a toroidal and a parabolic approximation. The liquid bridge was assumed to rupture through its thinnest neck leaving liquid distributed on each sphere. Experimental measurements showed that the rupture distance was well predicted by both profile approximations by assuming that rupture occurred when the liquid-vapor interfacial area of the bridge and the postrupture droplets was equal. Both bridge profile approximations only correctly predicted the evolution of the apparent contact angle and the extent of postrupture liquid distribution when the solid-liquid interfacial area measured throughout the separation was included in the calculations. This is because during the pendular liquid bridge elongation, the three-phase contact line usually begins to slip on at least one of the spheres. The parabolic profile approximation was slightly more accurate than the toroidal one. The toroidal approximation is more difficult to use because one of the parameters passes through infinity as the bridge changes from convex to concave in shape. In some cases the toroidal approximation was also unable to generate a solution. Copyright 2000 Academic Press.     

Hydrogel supported chiral imidazolidinone for organocatalytic enantioselective reduction of olefins in water

Chiral products play an important role particularly in the field of medicinal chemistry, where it is known that enantiomers often have very different biological properties and effects. One of the most powerful tool to obtain a product as a single enantiomer is asymmetric catalysis. Recently, organocatalysis, i.e. the use of small organic molecules to catalyze enantioselective transformations, has emerged as a prominent field in asymmetric synthesis. In this work, the use of hydrogels as a support for a chiral imidazolidinone organocatalyst (MacMillan catalyst) and its application in the reduction of activated olefins mediated by the Hantzsch ester is reported for the first time. Results showed a good activity of hydrogels in respect to both yield and enantioselection.