Site-Directed Surface Derivatization of MCM-41: Use of High-Resolution Transmission Electron Microscopy and Molecular Recognition for Determining the Position of Functionality within Mesoporous Materials

The “staining” cluster–crown compound [Ru₆C(CO)₁₄(η⁶-C₆H₄C₁₀H₂₀O₆)] verifies that the internal walls of mesoporous silica MCM-41 may be selectively functionalized with propylammonium groups (see picture). By the use of high-resolution transmission electron microscopy the presence and position of the cluster and also of the functional groups may be directly determined.     

Efficient synthesis of an adenosine A2a agonist: glycosylation of 2-haloadenines and an N2-alkyl-6-chloroguanine

A convergent synthesis of adenosine A2a agonist 1 in the form of its maleate salt 2 was achieved. The key step in this approach was the highly selective 9beta-glycosylation reaction between 2-haloadenines or an N(2)-alkyl-6-chloroguanine and a D-ribose derivative containing a 2-ethyltetrazolyl moiety. Glycosylations of other purine derivatives were also examined, and the methods developed provide efficient access to a variety of adenosine analogues such as 2-alkylaminoadenosines, an attractive class of compounds with antiinflammatory activity.     

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