Synthesis,crystal structure and antifungal activity of a divalent cobalt(II) complex with uniconazole

Azole compounds have attracted commercial interest due to their high bactericidal and plant‐growth‐regulating activities. Uniconazole [or 1‐(4‐chlorophenyl)‐4,4‐dimethyl‐2‐(1H‐1,2,4‐triazol‐1‐yl)pent‐1‐en‐3‐ol] is a highly active 1,2,4‐triazole fungicide and plant‐growth regulator with low toxicity. The pharmacological and toxicological properties of many drugs are modified by the formation of their metal complexes. Therefore, there is much interest in exploiting the coordination chemistry of triazole pesticides and their potential application in agriculture. However, reports of complexes of uniconazole are rare. A new cobalt(II) complex of uniconazole, namely dichloridotetrakis[1‐(4‐chlorophenyl)‐4,4‐dimethyl‐2‐(1H‐1,2,4‐triazol‐1‐yl‐κN⁴)pent‐1‐en‐3‐ol]cobalt(II), [CoCl₂(C₁₅H₁₈ClN₃O)₄], was synthesized and structurally characterized by element analysis, IR spectrometry and X‐ray single‐crystal diffraction. The crystal structural analysis shows that the Co^II atom is located on the inversion centre and is coordinated by four uniconazole and two chloride ligands, forming a distorted octahedral geometry. The hydroxy groups of an uniconazole ligands of adjacent molecules form hydrogen bonds with the axial chloride ligands, resulting in one‐dimensional chains parallel to the a axis. The complex was analysed for its antifungal activity by the mycelial growth rate method. It was revealed that the antifungal effect of the title complex is more pronounced than the effect of fungicide uniconazole for Botryosphaeria ribis, Wheat gibberellic and Grape anthracnose.     

Sulfur Ligands. from β-Lactam Antibiotics to Contrast Agents for MRI

Abstract

NMR, IR and semi empirical Molecular Orbital PM3 studies on selected β-lactam antibiotics are reported. The role of sulfur in β-lactam antibiotics is discussed.     

Nonexistence of <Emphasis Type="Italic">CW</Emphasis>(110, 100)

Using character theoretic methods, we settle the existence status of a circulant weighing matrix of order 110 with weight 100. This fills a missing entry in recent tables, thereby answering the existence of previously open CW (110,100) with answer “NO”.     

Evaluation of in vitro antioxidant activities of soyasaponins from soy hypocotyls in human HepG2 cell line

Soyasaponins were shown to have a wide range of biological activities in previous studies; however, the activities of their monomeric compounds are unclear. The aim of this study was to evaluate the in vitro antioxidant activities of soyasaponins in HepG2 cells. Four soyasaponins were isolated from soy hypocotyls and identified as soyasaponin Aa, Ab, Ba, and Bb. The protective effects of these soyasaponins against production of hydrogen peroxide-induced reactive oxygen species in cells were investigated. The cellular antioxidant activity of soyasaponins was found to be in a dose-dependent manner at concentrations ranging between 25 and 400 μg/mL in 24 h. Finally, based on cell morphology observations, group A soyasaponins showed better cellular antioxidant activity and anti-oxidative enzyme activity than group B ones, with an optimal concentration of 100 μg/mL.