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131.
An efficient and facile one-pot synthesis is described for the preparation of novel 2-amino-5-hydroxy-4H-chromene derivatives with a spirooxindole nucleus using Ca(OH)2-mediated three-component reactions of substituted resorcinols with isatins and malononitrile. This simple method provided a variety of biologically interesting diverse 2-amino-5-hydroxy-4H-chromene derivatives in moderate yields under mild reaction conditions. 相似文献
132.
Jong?Rok?Moon Min?Woong?Kim Dukjoon?Kim Ji?Hoon?Jeong Ji-Heung?KimEmail author 《Colloid and polymer science》2011,289(1):63-71
A series of amphiphilic graft copolymers based on polyaspartamide were synthesized by a successive aminolysis reaction of
polysuccinimide using 2-diisopropylaminoethyl (DIP) and laurylamine as a pH sensitive and hydrophobic group, respectively.
The pH-dependent self-assembly behavior of the aqueous copolymer solution was investigated. Nano-aggregation occurred at a
pH in the vicinity of the pKa of the DIP group, which was induced by a hydrophilic–hydrophobic shift of the DIP group in solution.
The mean diameter of the nano-aggregate could be modulated by changing the composition of both pendants. The mean diameter
of the nanoparticles increased with increasing solution pH from 6.5 to 8. At pH 8, the mean diameter of the nanoparticles
increased rapidly at the temperature above 45 °C, probably due to the change in hydrophilic–hydrophobic balance of the pH-sensitive
DIP moiety. The dissolution of paclitaxel (PTX) into this amphiphilic nanoparticle was attempted and the pH-dependent release
behavior was examined with the stability study of the particle. The results showed significantly faster release of PTX at
pH 6.5, which is a tumoral acidic pH, than in a neutral physiological pH. These thermo- and pH-sensitive polyaspartamide derivatives
have potential use as a tumor-targeting delivery. 相似文献
133.
Milavec Kapun Marija Drnovšek Rok Rajkovič Vladislav Rajkovič Uroš 《Central European Journal of Operations Research》2023,31(3):911-926
Central European Journal of Operations Research - Population ageing together with the greater prevalence of multimorbidity add to the need for and complexity of healthcare services. This makes it... 相似文献