Most of the novel highly potent drugs, developed on the basis of modern molecular medicine, taking into account cell surface recognition techniques, show poor water solubility. A chemical modification of the drug substance enhancing the solubility often decreases the pharmacological activity. Thus, as an alternative an increase of the solubility can be obtained by the reduction of the size of the drug particles. Unfortunately, it is often difficult to obtain micro or nanosized drug particles by classical or more advanced crystallization using supercritical gases or by milling techniques. In addition, nanosized particles are often not physically stable and need to be stabilized in an appropriate matrix. Thus, it may be of interest to manufacture directly nanosized drug particles stabilized in an inert hydrophilic matrix, i.e. nanostructured and nanocomposite systems. Solid solutions and solid dispersions represent nanostructured and nanocomposite systems. In this context, the use of the vacuum-fluidized-bed technique for the spray-drying of a low water soluble drug cosolubilized with a hydrophilic excipient in a polar organic solvent is discussed. In order to avoid the use of organic solvents, a special spray-freeze-drying technique working at atmospheric pressure is presented. This process is very suitable for temperature and otherwise sensitive drugs such as pharmaproteins. 相似文献
Summary We give a syntactic characterization of (finitary) theories whose categories of models are closed under the formation of connected limits (respectively the formation of pullbacks and substructures) in the category of all structures. They are also those theories whose consistent extensions by new atomic facts admit in each component an initial structure (respectively an initial term structure), and also thoseT for whichM(T) is locally finitely multi-presentable in a canonical way. We also show that these two properties of theories are nonuniform. 相似文献
We analyze diffusion from a periodic array of hemispherical droplets through a membrane. We find that the multiple sources do not interact strongly, even when the droplets are closely spaced, so that the flux through the membrane appears nearly additive. 相似文献
RSMR experiments with57Fe radiation were performed on myoglobin. An areasensitive detector was employed for simultaneous angular dependent collection of the scattered quanta up to a maximum angle 2θ of 17‡. Experimental data of polycrystalline and lyophilized myoglobin are compared with computer calculations of the scattering which are based on the atomic coordinates determined by X-ray structure analysis. Special attention has been paid to the influence of coherence effects from collectively moving parts of the protein. A simple model is introduced in order to take into account these segmental motions. Our first results indicate that the sizes of collectively moving segments are comparable with spheres of about 6 å in diameter in dry myoglobin. In myoglobin crystals, where the molecules are surrounded by large hydration shells, the movements appear to be correlated in segments with sizes comparable to helices.
The general structure of the pureSU(2) gauge potentials is calculated in detail. It is shown that the expansion of the gauge potentials about nonvanishing pure gauge potentials gives rise to new effects with confinement character. 相似文献
We describe a means of constructing splittings of a one-ended finitely generated group over two-ended subgroups, starting with a finite collection of codimension-one two-ended subgroups. In the case where all the two-ended subgroups have two-ended commensurators, we obtain an annulus theorem, and a form of the JSJ splitting of Rips and Sela. The construction uses ideas from the work of Dunwoody, Sageev and Swenson. We use a particular kind of order structure which combines cyclic orders and treelike structures. In the special case of hyperbolic groups, this provides a link between combinarorial constructions, and constructions arising from the topological structure of the boundary. In this context, we recover the annulus theorem of Scott and Swarup. We also show that a one-ended finitely generated group which contains an infinite-order element, and such that every infinite cyclic subgroup is (virtually) codimension-one is a virtual surface group.
We study the recent construction of subfactors by Rehren which generalizes the Longo–Rehren subfactors. We prove that if
we apply this construction to a non-degenerately braided subfactor N⊂M and α±-induction, then the resulting subfactor is dual to the Longo–Rehren subfactor M⊗Mopp⊂R arising from the entire system of irreducible endomorphisms of M resulting from αplusmn;-induction. As a corollary, we solve a problem on existence of braiding raised by Rehren negatively. Furthermore, we generalize
our previous study with Longo and Müger on multi-interval subfactors arising from a completely rational conformal net of factors
on S1 to a net of subfactors and show that the (generalized) Longo–Rehren subfactors and α-induction naturally appear in this context.
Received: 11 September 2001 / Accepted: 7 October 2001 相似文献
The structural evolution in amorphous silicon and germanium thin films has been investigated by high-resolution transmission electron microscopy (HRTEM) in conjunction with autocorrelation function (ACF) analysis. The results established that the structure of as-deposited semiconductor films is of a high density of nanocrystallites embedded in the amorphous matrix. In addition, from ACF analysis, the structure of a-Ge is more ordered than that of a-Si. The density of embedded nanocrystallites in amorphous films was found to diminish with annealing temperature first, then to increase. The conclusions also corroborate well with the results of diminished medium-range order in annealed amorphous films determined previously by a variable coherence microscopy method. 相似文献