50 dB parametric on-chip gain in silicon photonic wires

A pulsed mid-infrared pump at λ=2173 nm is used to demonstrate wideband optical parametric gain in a low-loss 2 cm long silicon photonic wire. Using dispersion engineering to obtain negative second-order (β2) and positive fourth-order (β4) dispersion, we generate broadband modulation instability and parametric fluorescence extending from 1911 nm-2486 nm. Using a cw probe signal to interrogate the modulation instability spectrum, we demonstrate parametric amplification >40 dB with an on-chip gain bandwidth wider than 580 nm, as well as narrowband Raman-assisted peak gain >50 dB.     

A sensitive and simple ultra-high-performance-liquid chromatography-tandem mass spectrometry based method for the quantification of D-amino acids in body fluids

D-Amino acids are increasingly being recognized as important signaling molecules in mammals, including humans. D-Serine and D-aspartate are believed to act as signaling molecules in the central nervous system. Interestingly, several other D-amino acids also occur in human plasma, but very little is currently known regarding their function and origin. Abnormal levels of D-amino acids have been implicated in the pathogenesis of different diseases, including schizophrenia and amyotrophic lateral sclerosis (ALS), indicating that D-amino acid levels hold potential as diagnostic markers. Research into the biological functions of D-amino acids is hindered, however, by the lack of sufficiently sensitive, high-throughput analytical methods. In particular, the interference of large amounts of L-amino acids in biological samples and the low concentrations of D-amino acids are challenging. In this paper, we compared 7 different chiral derivatization agents for the analysis of D-amino acids and show that the chiral reagent (S)-NIFE offers outstanding performance in terms of sensitivity and enantioselectivity. An UPLC-MS/MS based method for the quantification of D-amino acids human biological fluids was then developed using (S)-NIFE. Baseline separation (R(s)>2.45) was achieved for the isomers of all 19 chiral proteinogenic amino acids. The limit of detection was <1 nM for all amino acids except d-alanine (1.98 nM), d-methionine (1.18 nM) and d-asparagine (5.15 nM). For measurements in human plasma, cerebrospinal fluid and urine, the accuracy ranged between 85% and 107%. The intra-assay and inter-assay were both <16% RSD for these three different matrices. Importantly, the method does not suffer from spontaneous racemization during sample preparation and derivatization. Using the described method, D-amino acid levels in human cerebrospinal fluid, plasma and urine were measured.     

Nonlinear absorption and refraction in crystalline silicon in the mid‐infrared

The wavelength dependence of the nonlinear absorption and the third order nonlinear refraction of crystalline silicon between m and m as well as at m have been measured. It was found that at all wavelengths multi‐photon and free carrier absorption can be significant. In particular nonlinear absorption can affect silicon devices designed for the mid‐infrared that require strong nonlinear response, such as for the generation of a supercontinuum.     

Flexible modeling based on copulas in nonparametric median regression

Consider the model Y=m(X)+ε, where m(⋅)=med(Y|⋅) is unknown but smooth. It is often assumed that ε and X are independent. However, in practice this assumption is violated in many cases. In this paper we propose modeling the dependence between ε and X by means of a copula model, i.e. (ε,X)∼C_θ(F_ε(⋅),F_X(⋅)), where C_θ is a copula function depending on an unknown parameter θ, and F_ε and F_X are the marginals of ε and X. Since many parametric copula families contain the independent copula as a special case, the so-obtained regression model is more flexible than the ‘classical’ regression model.We estimate the parameter θ via a pseudo-likelihood method and prove the asymptotic normality of the estimator, based on delicate empirical process theory. We also study the estimation of the conditional distribution of Y given X. The procedure is illustrated by means of a simulation study, and the method is applied to data on food expenditures in households.     

Scattering at sidewall roughness in photonic crystal slabs

We have simulated the effect of sidewall roughness in photonic-crystallike structures with different vertical refractive-index contrast. We treated the scattering off a sidewall irregularity as a radiating dipole excited by the incident waveguide mode. We show that the loss that is due to this scattering is significantly larger for structures with a low refractive-index contrast (such as GaAs/AlGaAs waveguides) than for structures with a high vertical index contrast (such as silicon-on-insulators and membranes).     

Electron impact-induced fragmentation of 2,1-benzisothiazoline 2,2-dioxide

The electron impact-induced fragmentation patterns of 2,1-benzisothiazoline 2,2-dioxide nitro derivatives were studied. The rationalizations proposed for the fragmentations are supported by accurate mass measurements, daughter ion (mass analysed ion kinetic energy and B/E linked-scan), parent ion, and constant neutral loss spectra in metastable and collision-induced dissociation modes and deuterium labelling.     

Advanced boundary conditions for eigenmode expansion models

In order to realise the full potential of eigenmode expansion models, advanced boundary conditions are required that can absorb the radiation impinging on the walls of the discretisation volume. In this paper, we will discuss and compare a number of these boundary conditions, like perfectly matched layers (PMLs), open (leaky mode) boundary conditions and transparent boundary conditions (TBCs). We will also introduce the case of PMLs with infinite absorption and discuss its relation to leaky mode expansion, leading to a deeper insight into the physics of PML.