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861.
It is well known that laser scattered-light applicators when applied for laser-induced tumor therapy allow the precise thermal destruction of metastases. Using laser radiation in the NIR spectral range (usually, Nd:YAG laser systems λ = 1064 nm), a penetration depth of 5–10 cm (1/e is the decrease in radiation intensity) is achieved in biological tissues. The major tissue-optical parameters, i.e., absorption coefficient μa, scattering coefficient μs, and the anisotropy factor g, show biological tissues to be strongly scattering media which have a so-called optical window in the NIR. As a consequence, the therapeutic laser radiation is scattered and absorbed at a deeper level, leading to a virtual enlargement of the laser applicator. The thermal sclerotization and the thermal cell damage originate within the absorbing volume of the laser radiation and spread outward by thermal diffusion. There are three dosimetrically relevant zones of thermal and biological damage: (1) a zone of thermal coagulation; (2) a threshold of partial necrosis (destruction of all metabolic processes in the cell is the maintenance of essential parts of the cytoskeleton and the plasma membrane); this is characterized by a specific temperature range, the so-called phase transition, which refers to the transition from the gel phase of the biomembrane to the fluid phase; the determination of this temperature zone is an integral part of the following experimental investigations on MX1 cells; (3) an external zone of thermal effects made up of partial and multiple damage with a statistical chance of survival. This paper describes the investigations on heat stress in cancer cells to verify the maximum phase transition of the outer MX1 cell membranes and the related results. For this purpose, a novel method of quantum dot fluorescence dosimetry was developed. The evaluation of the measured laser-induced fluorescences yields a first approximation of the determination of the phase transition on MX1 cells. 相似文献
862.
Corrosion-related defects of pure iron were investigated by measuring Doppler broadening energy spectra (DBES) of positron annihilation and positron annihilation lifetime (PAL). Defect profiles of the S-parameter from DBES as a function of positron incident energy up to 30 keV (i.e. ∼1 μm depth) were analyzed. The DBES data show that S-parameter increases as a function of positron incident energy (mean depth) after corrosion, and the increase in the S-parameter is larger near the surface than in the bulk due to corrosion. Furthermore, information on defect size from PAL data as a function of positron incident energy up to 10 keV (i.e. ∼0.2 μm depth) was analyzed. In the two-state trapping model, the lifetime τ2 = 500 ps is ascribed to annihilation of positrons in voids with a size of the order of nanometer. τ1, which decreases with depth from the surface to the bulk, is ascribed to the annihilation of positrons in dislocations and three-dimensional vacancy clusters. The corroded samples show a significant increase in τ1 and the intensity I2, and near the surface the corroded iron introduces both voids and large-size three-dimensional vacancy clusters. The size of vacancy clusters decreases with depth. 相似文献
863.
Applied Biochemistry and Biotechnology - 相似文献
864.
Gap detection thresholds were measured by forced-choice procedure for conditions where the duration of a silent gap was varied adaptively between pairs of sinusoidal markers of the same or different frequency. Frequencies of the first sinusoid in a pair of markers ranged from F1 = 500 to 4000 Hz. Second-sinusoid marker frequencies F2 included F1 = F2, and usually frequencies 2%, 5%, 24%, and 50% higher than F1. In preliminary studies the role of presentation level (E/N0) on gap detection was considered. Preliminary data revealed confounding extraneous factors arising from gating transients and from overall stimulus (i.e., markers + gap) and/or masker duration cues. In the main experiments, the contributions of these extraneous cues were evaluated with experimental designs aimed at identifying and minimizing the confounding roles of these cues in gap detection. For conditions where extraneous gating transient cues were minimized (by presenting the sinusoidal markers in a continuous noise masker with random onset phase for the second sinusoid in every pair of markers) and overall stimulus duration cues were diminished (by randomizing the duration of each marker independently), gap detection thresholds increased from 5 to 90 ms as the frequency separation between F1 and F2 was increased by half an octave. When the gap detection thresholds were treated as filter attenuation values by normalizing and converting the data into decibels, the data were closely fit by the roex filter model. On average, the listeners' performances were modeled well by a constant-percentage (7%) bandwidth filter centered on F1. 相似文献
865.
Robert S. Maier 《Random Structures and Algorithms》1991,2(4):379-420
We analyze the performance of a prototypical scheme for shared storage allocation: two initially empty stacks evolving in a contiguous block of memory of size m. We treat the case in which the stacks are more likely to shrink than grow, but with the probabilities of insertion and deletion allowed to depend arbitrarily on stack height as a fraction of m. New results are obtained on the m → ∞ asymptotics of the stack collision time, and of the final stack heights. The results of Wentzell and Freidlin on the large deviations of Markov chains are used, and the relation of their formalism to the Hamiltonian formulation of classical mechanics is emphasized. Certain results on higher-order asymptotics follow from WKB expansions. 相似文献
866.
C. Praagman 《Aequationes Mathematicae》1987,33(1):251-259
In this paper it is proved that having a logarithm is equivalent to having roots of arbitrary order in the group of automorphisms of a formal power series ring, and in algebraic subgroups too 相似文献
867.
We report viscometric data collected in a Couette rheometry on dilute, single‐solvent polystyrene (PS)/dioctyl phthalate (DOP) solutions over a variety of polymer molecular weights (5.5 × 105 ≤ Mw ≤ 3.0 × 106 Da) and system temperatures (288 K ≤ T ≤ 318 K). In view of the essential viscometric features, the current data may be classified into three categories: The first concerns all the investigated solutions at low shear rates, where the solution properties are found to agree excellently with the Zimm model predictions. The second includes all sample solutions, except for high‐molecular‐weight PS samples (Mw ≥ 2.0 × 106 Da), where excellent time–temperature superposition is observed for the steady‐state polymer viscosity at constant polymer molecular weights. No similar superposition applies at a constant temperature but varied polymer molecular weights, however. The third appears to be characteristic of dilute high‐molecular‐weight polymer solutions, for which the effects of temperature on the viscosity curve are further complicated at high shear rates. The implications concerning the relative importance of hydrodynamic interactions, segmental interactions, and chain extensibility with increasing polymer molecular weight, system temperature, and shear rate are discussed. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 787–794, 2006 相似文献
868.
J. Jiang B.Y. Jiang C.X. Ren F.M. Zhang T. Feng X. Wang X.H. Liu S.C. Zou 《Applied Surface Science》2006,252(10):3642-3646
Hafnium and platinum were deposited onto molybdenum grids by ion-beam assisted deposition method. Electron-emission characteristics from molybdenum grids with Hf and Pt films, which were contaminated by active electron-emission substances (Ba, BaO) of the cathode, were measured using analogous diode method. The surfaces of grids were analyzed by X-ray diffraction. The results revealed that the reaction between BaO and Hf formed BaHfO3 compound, which greatly reduced the accumulation of BaO on the surface and accordingly decreased grid emission. In contrast, Ba were formed by the decomposition of BaO on the surface of Pt film under high temperature and re-evaporated from its surface, which reduced the active electron-emission substances on the surface of the grid and effectively restrained grid emission. Their mechanisms for grid-emission suppression are discussed and a good method to develop new grid-coating materials is suggested. 相似文献
869.
870.
Binding energy spectra of the valence electrons of the open shell molecule NO have been obtained up to 55 eV at azimuthal angles of 0° and 7° using binary (e, 2e) spectroscopy at an impact energy of 1200 eV. The momentum distribution has been obtained for the least tightly bound (unpaired) electron, removal of which leads to formation of the X 1Σ+ ground state of NO+. Momentum distributions have also been measured at 21.0 and 40.5 eV. The measured momentum distributions are compared with several literature wavefunctions of varying complexity. They are found to be in excellent agreement with those calculated using the natural spin orbital wavefunctions of Kouba and Ohrn. 相似文献