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Joyce A. McMillan Yang M. Goo Kenneth L. Rinehart William C. Krueger Loraine M. Pschigoda 《Tetrahedron letters》1981,22(1):39-42
The structure of aerothionin, a tyrosine-derived brominated compound from the sponge (Pallas), is confirmed by X-ray data, which with CD data assign its absolute configuration. 相似文献
63.
J. B. Hudson H. Saboune Z. Abramowski G. H. N. Towers K. L. Rinehart Jr. 《Photochemistry and photobiology》1988,47(3):377-381
Abstract— Five eudistomins, β-carboline derivatives isolated from a Caribbean tunicate, were tested for phototoxicity against several viruses, bacteria, yeast, and mammalian cells. The five compounds showed varying degrees of UVA dependant phototoxicity (i.e. long wavelength UV dependant) against murine cytomegalovirus (MCMV), Sindbis virus (SV) and mouse 3T3 cells, although the relative order of potency was the same for these three organisms. Eudistomin N was the most active (approximately the same as the β-carboline, harmine), while eudistomins M and O were moderately phototoxic, and H and I had little activity. To some degree the relative phototoxicity was correlated with fewer side chain substituents. A similar relative order of phototoxic potency was seen against phage T4, but in this case the magnitude of the effect was considerably reduced, in contrast to harmine. The antibacterial and antifungal activities were not correlated with antiviral effects, and some UVA-independent activities were seen. Thus the eudistomins may possess different mechanisms of action against different organisms, depending upon the presence or absence of UVA. 相似文献
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Lomofungin. I. Degradative studies of a new phenazine antibiotic 总被引:1,自引:0,他引:1
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Kantilal S. Patel Kenneth L. Rinehart John C. Bailar 《Journal of mass spectrometry : JMS》1970,3(10):1239-1254
Detailed comparison of the fragmentation behavior of a series of beryllium β-diketonates with that of the corresponding series of β-diketones reveals a number of striking differences. A-typical fragmentations are observed for diketones and diketonates with trifluoromethyl and α-phenyl substituents. 相似文献
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