Effects of photodynamic therapy on the absorption properties of disulphonated aluminum phthalocyanine in tumor-bearing mice

Time-resolved reflectance spectroscopy was performed on tumor-bearing mice, administered with disulphonated aluminum phthalocyanine (AlS(2)Pc, 5 mg/kg body weight), before, during and after photodynamic therapy. This allowed us to evaluate the absorption spectrum of AlS(2)Pc in vivo from 610 to 700 nm, and to investigate how the therapeutic irradiation affects it. Two tumor locations (intraderma on the back and intramuscular in the leg), and two uptake times (3 and 12 h) were considered. As already observed previously, the absorption spectrum of AlS(2)Pc in vivo is centered at 680-685 nm. The irradiation causes a blue-shift of the measured line shape, more or less marked depending on the experimental conditions. A reduction in absorption is also often observed upon illumination with therapeutic light doses.     

On 2x2 conservation laws with large data

We deal with a strictly hyperbolic system of two conservation laws in one spatial dimension. One of the eigenvalues of the system is of Temple type (rarefaction and shock curves coincide), the other eigenvalue is only required to be genuinely nonlinear.We consider the initial value problem for data of the following kind: the total variation of the Temple component is bounded, possibly large, while the total variation of the other component is small. For such data we prove global existence, uniqueness and L⊃-Lipschitz continuous dependence of solutions.AMS Subject Classification: Primary 35L65; Secondary 35D05, 35L45.     

Quantification by random walk of the optical parameters of nonlocalized abnormalities embedded within tissuelike phantoms

We have extended a random-walk theory that uses time-dependent contrast functions to quantify the cross section and the corrected scattering and absorption coefficients of abnormal nonlocalized targets from time-of-flight (TOF) data obtained in time-resolved transillumination experiments. Experimental TOF's are used to show that this newly developed random-walk method is able to quantify the size and the optical properties of embedded nonlocalized targets in with an error rate of 相似文献   

NONLOCAL CROWD DYNAMICS MODELS FOR SEVERAL POPULATIONS

This paper develops the basic analytical theory related to some recently introduced crowd dynamics models.Where well posedness was known only locally in time,it is here extended to all of R+.The result...     

Pedestrian flows and non‐classical shocks

We present a model for the flow of pedestrians that describes features typical of this flow, such as the fall due to panic in the outflow of people through a door. The mathematical techniques essentially depend on the use of non‐classical shocks in scalar conservation laws. Copyright © 2005 John Wiley & Sons, Ltd.     

Experimental and mechanistic investigation of an iodomalonic acid-based Briggs-Rauscher oscillator and its perturbations by resorcinol

Classic Briggs-Rauscher oscillators use malonic acid (MA) as a substrate. The first organic product is iodomalonic acid. Iodomalonic acid (IMA) can serve as a substrate also; thus, the first product in that case is diiodomalonic acid (I(2)MA). Nonoscillating iodination kinetics can be followed by absorbance at 462 nm in acidic KIO(3) so long as IMA is in substantial excess over [I(2)]. At 25 °C, simulations lead to the two most important rate laws, and related rate constant estimates are reported. I(2)MA eventually decomposes by unknown processes, but I(2), O(2), H(2)O(2), and Mn(2+) speed up that decomposition, liberating most of the iodine back to the solution. Resorcinol is an effective inhibitor of oscillations both in MA oscillators and in IMA oscillators. Response of an IMA oscillator to varying amounts of resorcinol is shown herein and is similar to that for MA-based oscillators. The inhibitory effect of resorcinol is diminished by addition of IMA to a MA-based oscillator. The iodination reaction between IMA and resorcinol is too slow (0.043 M(-1) s(-1)) to account for the decreased inhibitory effectiveness of resorcinol. Rather, the decomposition of I(2)MA is responsible for the inhibition decrease.     

Organometallic mediated radical polymerization of vinyl acetate with Fe(acac)2

The radical polymerization of vinyl acetate (VAc) is moderated by iron(II) acetylacetonate (Fe(acac)₂) by the organometallic route (OMRP), as well as by degenerative transfer polymerization (DTP) when in the presence of excess radicals, through the formation of thermally labile organometallic Fe^III dormant species. The poly(vinyl acetate) (PVAc)‐Fe^III(acac)₂ dormant species has been isolated in the form of an oligomer and characterized by ¹H NMR, EPR, and IR methods, and then used as a single‐component initiator for the OMRP of VAc. The degree of polymerization of this isolated oligomeric species demonstrates the limited ability of Fe(acac)₂, relative to the Co(acac)₂ congener, to rapidly trap the growing PVAc radical chain. Control under OMRP conditions is improved by the presence of Lewis bases, especially PMe₂Ph. On the other hand, iron(II) phthalocyanine inhibits the radical polymerization of VAc completely. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 3494–3504     

New technique of processing highly oriented poly(vinylidene fluoride) films exclusively in the β phase

Oriented β‐phase films were obtained by utilizing two different techniques: conventional uniaxial drawing at 80 °C of predominantly α‐phase films, and by drawing almost exclusively β‐phase films obtained by crystallization at 60 °C from dimethylformamide (DMF) solution with subsequent pressing. Wide angle X‐ray diffraction (WAXD) and pole figure plots showed that with the conventional drawing technique films oriented at a ratio (R) of 5 still contained about 20% of phase α, a crystallinity degree of 40% and β‐phase crystallographic c ‐axis orientation factor of 0.655. Drawing at 90 °C and with R = 4 of originally β‐phase films results in exclusively β‐phase films with crystallinity degree of 45% and orientation factor of 0.885. Crystalline phase, crystallinity degree, and crystallographic c‐axis orientation factor of both phases were also determined for α‐phase oriented films obtained by drawing α‐phase films at 140 °C. For films drawn at 140 °C the α to β phase transition drops to about 22%. Reduction in crystallinity degree with increasing R is more pronounced at draw temperature of 140 °C compared with 80 °C. Moreover, for both phases the c ‐axis orientation parallel to the draw direction is higher at draw temperature of 140 °C than at 80 °C. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 2793–2801, 2007     

First order phase equilibrium for classical bodies

Summary In this note the Author gives a general and unified treatment of first order phase equilibria for classical bodies like those considered by Truesdell and Toupin in[3].The Author reaches a system of partial differential equations (generalized Clapeyron equations) the conditions of whose solution are shown always to be satisfied.In particular, the Author derives the equations governing the polarized phase equilibrium for a fluid.Besides the equations ruling the phase equilibrium for a two phase n-component fluid mixture are given and the equivalence with the statical Gibbs-Duhem relation is shown.

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Sommario In questa nota l'Autore presenta una trattazione generale ed unificata degli equilibri di fase del primo ordine per corpi classici come quelli definiti da Truesdell e Toupin in[3].L'Autore perviene ad un sistema di equazioni alle derivate parziali (equazioni di Clapeyron generalizzate) del quale si dimostra la integrabilità.In particolare, si deducono le equazioni che governano gli equilibri di fase polarizzati.Inoltre si ottengono le equazioni che regolano l'equilibrio di fase per una miscela fluida a n componenti; in questo caso si dimostra l'equivalenza delle equazioni con la relazione statica di Gibbs-Duhem.

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This work was supported by the Gruppo Nazionale per la Fisica Matematica of C.N.R.