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151.
Yuri N. Belokon’Devayani Bhave Daniela D'AddarioElizabetta Groaz Viktor MaleevMichael North Armine Pertrosyan 《Tetrahedron letters》2003,44(10):2045-2048
Copper(salen) complex 1 has been found to catalyse the asymmetric alkylation of enolates derived from a variety of amino acids. There is a clear relationship between the size of the side chain in the substrate and the enantioselectivity of the process, so that the enantioselectivity decreases in the order alanine>aminobutyric acid>allylglycine>leucine>phenylalanine>valine. A transition state model which accounts for the influence of the size of the side chain on the enantioselectivity of the reactions is presented. 相似文献
152.
Dr. Chiara Platella Dr. Ettore Napolitano Dr. Claudia Riccardi Prof. Domenica Musumeci Prof. Daniela Montesarchio 《ChemistryOpen》2022,11(5):e202200090
DNA G-quadruplexes (G4s) are key structures for the development of targeted anticancer therapies. In this context, ligands selectively interacting with G4s can represent valuable anticancer drugs. Aiming at speeding up the identification of G4-targeting synthetic or natural compounds, we developed an affinity chromatography-based assay, named G-quadruplex on Oligo Affinity Support (G4-OAS), by synthesizing G4-forming sequences on commercially available polystyrene OAS. Then, due to unspecific binding of several hydrophobic ligands on nude OAS, we moved to Controlled Pore Glass (CPG). We thus conceived an ad hoc functionalized, universal support on which both the on-support elongation and deprotection of the G4-forming oligonucleotides can be performed, along with the successive affinity chromatography-based assay, renamed as G-quadruplex on Controlled Pore Glass (G4-CPG) assay. Here we describe these assays and their applications to the screening of several libraries of chemically different putative G4 ligands. Finally, ongoing studies and outlook of our G4-CPG assay are reported. 相似文献
153.
Two-step, one-pot neopentylglycolborylation of aryl iodides and bromides catalyzed by NiCl2(dppe) and NiCl2(dppp) is reported. Electron-rich and electron-deficient aryl neopentylglycolboronates were efficiently cross-coupled with aryl iodides, bromides, chlorides, mesylates, and tosylates by exploiting complementary Pd/Ni and Ni/Ni catalysis. The borylation route was further extended to a three-step, one-pot synthesis of biaryls via in situ Ni-catalyzed borylation and Pd-mediated cross-coupling. 相似文献
154.
155.
Mauro M Panigati M Donghi D Mercandelli P Mussini P Sironi A D'Alfonso G 《Inorganic chemistry》2008,47(23):11154-11165
The three complexes [Re2(mu-X1)(mu-X2)(CO)6(mu-ppd-kappaN3:kappaN4)] (X1, X2 ) H, 1; X1 ) H, X2 ) Cl, 2; X1, X2 ) Cl, 3; ppd) 2,5-diphenyl-1,3,4-oxadiazole) have been synthesized by different routes, involving the reaction of [Re4(mu3-H)4(CO)12]with ppd for 1, the reaction of 1 with HCl for 2, and the reaction of [ReCl(CO)5] with ppd for 3. The three complexes possess a different number of valence electrons, so the formal Re-Re bond order varies from 2 to 1 to 0 in complexes 1, 2, and 3, respectively. This is reflected in the Re-Re bond distance (277.9, 297.9, and 358.5 pm in the same series)and in the stability of the complexes in the coordinating solvent acetonitrile (t1/2 for ppd displacement 13.6, 4.5, and 3.7 h,for 1, 2, and 3, respectively). Both experimental and calculated structures indicates that coordination induces a distortion from planarity of the diphenyloxadiazole moiety due to the interaction of the equatorial carbonyls with the bridging ppd,which increases on going from 1 to 2 to 3 (dihedral angle between the oxadiazole and the phenyl rings 18.4 degrees, 23.3 degrees, and 45.0 degrees, respectively). The UV spectra show pi-pi* transitions of the oxadiazole ligand (which shift to higher energy on increasing the distortion from the planarity, from 252 to 267 nm) and metal-to-ligand charge transfer absorptions (from 300 to 362 nm). Upon irradiation between 340 and 380 nm, complex 2 only features a weak broad emission at 527 nm(phi)0.02%), whereas upon excitation at 300 nm, the emission typical of free ppd is observed, suggesting photodissociation.Cyclic voltammetry investigations in acetonitrile showed that the three complexes exhibit ligand-centered irreversible reduction peaks (from -1.83 to -1.93 V vs Fc+|Fc), shifted to more positive values with respect to free ppd (-2.50 V). The shift however is smaller than in the analogous derivatives containing 1,2-diazines, suggesting a smaller electron depletion of the heterocycle ligand upon coordination. The complexes also show a metal-centered, bi-electronic, irreversible oxidation peak (from 1.05 to 1.37 V vs Fc+/Fc). A combined density functional and time-dependent density functional (TD DFT)study allowed us to understand the factors affecting the stability of the three complexes and to rationalize their electrochemical and photophysical properties in terms of their electronic structure. 相似文献
156.
Catarina Gonalves Daniela Fernandes Inês Silva Vanessa Mateus 《Molecules (Basel, Switzerland)》2022,27(3)
This systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. Treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments. 相似文献
157.
Irina Ielciu Mihaela Niculae Emoke Pall Cristina Barblat Ioan Tomu Neli-Kinga Olah Ramona Flavia Burtescu Daniela Benedec Ilioara Oniga Daniela Hanganu 《Molecules (Basel, Switzerland)》2022,27(13)
Rosmarinus officinalis L. is a species that is widely known for its culinary and medicinal uses. The purpose of the present study consisted of the evaluation of the antiproliferative and antimicrobial effects of R. officinalis-loaded liposomes (L-R). Characterization of the liposomes was performed by establishing specific parameters. The load of the obtained liposomes was analyzed using an LC-MS method, and antiproliferative assays evaluated the cell viability on a liver adenocarcinoma cell line and on a human hepatic stellate cell line. Antimicrobial assays were performed by agar–well diffusion and by broth microdilution assays. The obtained liposomes showed high encapsulation efficiency, suitable particle size, and good stability. High amounts of caffeic (81.07 ± 0.76), chlorogenic (14.10 ± 0.12), carnosic (20.03 ± 0.16), rosmarinic (39.81 ± 0.35), and ellagic (880.02 ± 0.14) acids were found in their composition, together with other polyphenols. Viability and apoptosis assays showed an intense effect on the cancerous cell line and a totally different pattern on the normal cells, indicating a selective toxicity towards the cancerous ones and an anti-proliferative mechanism. Antimicrobial potential was noticed against all tested bacteria, with a better efficacy towards Gram-positive species. These results further confirm the biological activities of R. officinalis leaf extract, and proposes and characterizes novel delivery systems for their encapsulation, enhancing the biological activities of polyphenols, and overcoming their limitations. 相似文献
158.
Fedor Gmry Daniela Bettinelli Laura Gherardi Giovanni Crotti 《Physica C: Superconductivity and its Applications》1998,310(1-4):48-51
Magnetic nature of the losses in superconducting wire carrying AC current implies that it should be possible to determine these losses in a contactless way. Ribbon-like samples are quite favorable for such an experiment, because a notable portion of magnetic flux related to losses ‘escapes' the sample volume and can be detected by an appropriate pick-up coil. In this case, a model describing the AC current penetration into the tape, based, e.g., on the critical state model, allows one to derive the losses from the pick-up coil signal. Because this signal is proportional to the number of coil turns, extension of the accessible range of measured voltages (and losses) can be achieved. We demonstrate the data obtained on a 1 cm long portion of a low-loss multifilamentary tape carrying AC current with frequency 35 Hz. The pick-up coil technique allowed us to reach loss level more than one order below the experimental limit for direct measurements. 相似文献
159.
A. Baldan Adriaan M. H. van der Veen Daniela Prauß Angelika Recknagel N. Boley Steve Evans Derek Woods 《Accreditation and quality assurance》2001,6(4-5):164-167
Many proficiency tests are operated with a consensus value derived from the participants’ results. Apart from technical issues,
one of the reasons often mentioned is that proficiency tests operated with consensus values would be cheaper than those using
reference values obtained from a priori characterisation measurements. The economy of a proficiency test must of course be balanced by the need of the participants,
and the quality of the comparison in general. The proficiency tests selected in this study had both a reference value and
a consensus value, one of which was used for assessing the performance of the participating laboratories. In this work, both
a technical and an economical assessment of how the comparisons were operated is made. From the evaluation, it follows that
usually the use of consensus values does not necessarily reduce the costs of a proficiency test. However, frequently it may
be observed that the quality of the assessment of the laboratories is better with a reference value.
Received: 11 October 2000 Accepted: 3 January 2001 相似文献
160.
Daniela M. Fidalgo Adriana A. Kolender Oscar Varela 《Journal of polymer science. Part A, Polymer chemistry》2013,51(2):463-470
Novel linear carbohydrate‐derived [m,n]‐polyurethanes are successfully prepared using D ‐mannitol as renewable and low cost starting material. The key comonomer, 1,6‐di‐O‐phenylcarbonyl‐2,3,4,5‐tetra‐O‐methyl‐D ‐mannitol is polymerized with a diamine synthesized from D ‐mannitol or with alkylenediamines. These polymerization reactions afford, respectively, a [6,6]‐polyurethane entirely based on a carbohydrate derivative or [m,n]‐polyurethanes constituted by a poly‐O‐methyl substituted unit alternating with a polymethylene chain. All these polymers are stereoregular, as result of the C2 axis of symmetry of mannitol. The optically active polyurethanes are characterized by standard methods (FTIR, RMN, GPC, TGA, and DSC). Thus, GPC analysis reveals weight‐average molecular weights between 18,000 and 25,000 Da. Thermal studies (DSC) indicate that the polymers obtained are amorphous materials with Tg values dependent on the structure and chain length of the diamine constituent. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013 相似文献