Measurement of D0-D0 mixing parameters in D0 --> Ks pi+ pi- decays

We report a measurement of D0-D(0) mixing parameters in D(0) --> K(s)(0) pi(+) pi(-) decays using a time-dependent Dalitz-plot analysis. We first assume CP conservation and subsequently allow for CP violation. The results are based on 540 fb(-1) of data accumulated with the Belle detector at the KEKB e(+)e(-) collider. Assuming negligible CP violation, we measure the mixing parameters x = (0.80 +/- 0.29(-0.07-0.14)(+0.09+0.10))% and y = (0.33+/-0.24(-0.12-0.08)(+0.08+0.06))%, where the errors are statistical, experimental systematic, and systematic due to the Dalitz decay model, respectively. Allowing for CP violation, we obtain the CP-violating parameters |q / p| = 0.86(-0.29-0.03)(+0.30+0.06) +/- 0.08 and arg(q/p) = (-14(-18-3-4)(+16+5+2)) degrees .     

Evidence for CP violation in B0-->D+D- decays

We report measurements of the branching fraction and CP violation parameters in B(0)-->D+ D- decays. The results are based on a data sample that contains 535 x 10(6) BB pairs collected at the Upsilon(4S) resonance, with the Belle detector at the KEKB asymmetric-energy e+e- collider. We obtain [1.97+/-0.20(stat) +/- 0.20(syst)] x 10(-4) for the branching fraction of B0-->D+D-. The measured values of the CP violation parameters are S=-1.13+/-0.37+/-0.09, A=0.91+/-0.23+/-0.06, where the first error is statistical and the second is systematic. We find evidence of CP violation in B0-->D+D- at the 4.1sigma confidence level. While the value of S is consistent with expectations from other measurements, the value of the parameter A favors large direct CP violation at the 3.2sigma confidence level, in contradiction to standard model expectations.     

Observation of B decays to two kaons

Using 449x10(6) BB[over ] pairs collected with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider, we observe clear signals for B(+)-->K[over ](0)K(+) and B(0)-->K[over ](0)K(0) decays with 5.3sigma and 6.0sigma significance, respectively. We measure the branching fractions B(B(+)-->K[over ](0)K(+))=(1.22(-0.28-0.16)(+0.32+0.13))x10(-6) and B(B(0)-->K[over ](0)K(0))=(0.87(-0.20)(+0.25)+/-0.09)x10(-6), and partial-rate asymmetries A(CP)(B(+)-->K[over ](0)K(+))=0.13(-0.24)(+0.23)+/-0.02 and A(CP)(B(0)-->K[over ](0)K(0))=-0.58(-0.66)(+0.73)+/-0.04. From a simultaneous fit, we also obtain B(B(+)-->K(0)pi(+))=(22.8(-0.7)(+0.8)+/-1.3)x10(-6) and A(CP)(B(+)-->K(0)pi(+))=0.03+/-0.03+/-0.01. The first and second error in the branching fractions and the partial-rate asymmetries are statistical and systematic, respectively. No signal is observed for B(0)-->K(+)K(-) decays, and for this branching fraction, we set an upper limit of 4.1x10(-7) at the 90% confidence level.     

Dependence Measures for Extreme Value Analyses

Quantifying dependence is a central theme in probabilistic and statistical methods for multivariate extreme values. Two situations are possible: one where, in a limiting sense, the extremes are dependent; the other where, in the same sense, the extremes are independent. This paper comprises an overview of the principal issues through a unified approach which encompasses both these situations. Novel diagnostic measures for dependence are also developed which provide complementary information about different aspects of extremal dependence. The paper is written in an elementary style, with the methodology illustrated by application to theoretical examples and typical data-sets. These data-sets and the S-plus functions used for the analyses are available online.     

Sequence‐Specific DNA Alkylation by Tandem Py–Im Polyamide Conjugates

Tandem N‐methylpyrrole? N‐methylimidazole (Py? Im) polyamides with good sequence‐specific DNA‐alkylating activities have been designed and synthesized. Three alkylating tandem Py? Im polyamides with different linkers, which each contained the same moiety for the recognition of a 10 bp DNA sequence, were evaluated for their reactivity and selectivity by DNA alkylation, using high‐resolution denaturing gel electrophoresis. All three conjugates displayed high reactivities for the target sequence. In particular, polyamide 1 , which contained a β‐alanine linker, displayed the most‐selective sequence‐specific alkylation towards the target 10 bp DNA sequence. The tandem Py? Im polyamide conjugates displayed greater sequence‐specific DNA alkylation than conventional hairpin Py? Im polyamide conjugates ( 4 and 5 ). For further research, the design of tandem Py? Im polyamide conjugates could play an important role in targeting specific gene sequences.     

Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole–Imidazole Polyamide seco‐CBI Conjugates

Mutation of KRAS is a key step in many cancers. Mutations occur most frequently at codon 12, but the targeting of KRAS is notoriously difficult. We recently demonstrated selective reduction in the volume of tumors harboring the KRAS codon 12 mutation in a mouse model by using an alkylating hairpin N‐methylpyrrole–N‐methylimidazole polyamide seco‐1,2,9,9a‐tetrahydrocyclopropa[1,2‐c]benz[1,2‐e]indol‐4‐one conjugate (conjugate 4 ) designed to target the KRAS codon 12 mutation sequence. Herein, we have compared the alkylating activity of 4 against three other conjugates that were also designed to target the KRAS codon 12 mutation sequence. Conjugate 4 displayed greater affinity for the G12D mutation sequence than for the G12V sequence. A computer‐minimized model suggested that conjugate 4 could bind more efficiently to the G12D match sequence than to a one‐base‐pair mismatch sequence. Conjugate 4 was modified for next‐generation sequencing. Bind‐n‐Seq analysis supported the evidence showing that conjugate 4 could target the G12D mutation sequence with exceptionally high affinity and the G12V mutation sequence with much higher affinity than that for the wild‐type sequence.     

Particle tracking in Taylor–Couette flow

The paths of small inertial particles are computed in a steady Taylor vortex background flow. When buoyancy effects are neglected we find that particles denser than the background fluid tend to a limit orbit in the meridional plane. The difference in settling time and orbit size, with varying Reynolds number of the background flow, is investigated. We also consider the effect of the various forces on the limit orbit of the particle.     

Measurement of resistivity of soft magnetic laminations at elevated temperatures

The variation of resistivity in soft magnetic materials with temperature is extremely important for applications of electrical machines in aerospace applications. The design of a system for rapid and accurate measurement of the resistivity of Epstein strips under a wide range of temperatures is presented. Two cobalt–iron alloys are assessed up to 200 °C, showing significant differences in their resistivity but almost identical temperature coefficients of resistivity.     

Synthesizing chaotic maps with prescribed invariant densities

The Inverse Frobenius–Perron Problem (IFPP) concerns the creation of discrete chaotic mappings with arbitrary invariant densities. In this Letter, we present a new and elegant solution to the IFPP, based on positive matrix theory. Our method allows chaotic maps with arbitrary piecewise-constant invariant densities, and with arbitrary mixing properties, to be synthesized.     

Measurement of the near-threshold e+e- --> D(*)+/-D(*)-/+ cross section using initial-state radiation

We report a measurement of the exclusive e+e- -->D(*)+/-D*-/+ cross section as a function of center-of-mass energy near the D(*)+/-D*-/+ threshold with initial-state radiation. A partial reconstruction technique is used to increase the efficiency and to suppress background. The analysis is based on a data sample collected with the Belle detector with an integrated luminosity of 547.8 fb(-1).