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41.
Adsorption of cations (Na(+), Ca(2+), Ba(2+)) onto negatively charged (pH 10.4) hematite (alpha-Fe(2)O(3)) particles has been studied. The oxide material was carefully prepared in order to obtain monodisperse suspensions of well-crystallized, quasi-spherical particles (50 nm in diameter). The isoelectric point (IEP) is located at pH 8.5. Adsorption of barium ions onto oxide particles was carried out and the electrophoretic mobility was measured throughout the adsorption experiment. Comparison with calcium adsorption at full coverage reveals a higher uptake of Ba(2+). In both cases it shows also that chloride ions coadsorb with M(2) ions. Simultaneous uptake of the positive and negative ions explains why the electrophoretic mobility does not reverse to cationic migration. A theoretical study of the surface speciation has been carried out, using the MuSiC model. It reveals the presence of negative as well as positive sites on both sides of the point of zero charge (PZC) of the hematite particles, which may explain the coadsorption of Ba(2+) and Cl(-) at pH 10.4. The effective charge of the oxide particles, calculated from the electrophoretic mobility, is in very good agreement with the results found with the MuSiC modelization and the chloride/barium adsorption ratio. It also verifies the theory of ionic condensation. Calorimetric measurements gave a negative heat for the overall reaction occurring when Ba(2+)/Cl(-) ions adsorb onto hematite. Despite the fact that anions (Cl(-) and OH(-)) adsorption onto mineral oxides is an exothermic phenomenon, it is likely that barium and calcium adsorption is endothermic, denoting the formation of an inner-sphere complex as reported in the literature. 相似文献
42.
Philippe Renaud Michle Gerster 《Angewandte Chemie (International ed. in English)》1998,37(19):2562-2579
The neglect of free radicals over the past few years has been overcome, and they are no longer only considered as interesting reactive intermediates with limited synthetic potential. New opportunities are opened up by performing radical reactions in the presence of Lewis acids. Rate enhancement of radical addition to olefins as well as stereochemical control of such reactions can be achieved in a unique manner. Recent examples of enantioselective radical reactions and perspectives for applications in catalysis are discussed. 相似文献
43.
De Winter J Lemaur V Ballivian R Chirot F Coulembier O Antoine R Lemoine J Cornil J Dubois P Dugourd P Gerbaux P 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(35):9738-9745
Ion mobility spectrometry coupled with mass spectrometry was used to experimentally determine the three-dimensional structure of multiply charged sodium cationized polylactides (PLA). In particular, the experiments were conducted to evaluate the influence of the charge state and the size on the gas-phase conformation of cationized PLA. The measured collision cross sections were then compared to calculated values obtained by computational chemistry methods. The most striking feature was the experimental and theoretical observation of a breaking point in the quasilinear relationship between the average collision cross sections and the number of monomer units for the triply charged cations. This breaking point was theoretically demonstrated, for the doubly and triply charged cations, to be associated with a significant folding of the polymer chains around the cationizing agents. The occurrence of such breaking points could be exploited to correlate the charge state of the most intense ion series observed upon electrospray ionization with the number-average molecular mass of a polymer. 相似文献
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46.
Renaud Beaudegnies Alain De Mesmaeker Aurélie Mallinger Myriam Baalouch André Goetz 《Tetrahedron letters》2010,51(20):2741-3222
We report the design and the efficient synthesis of novel spirocyclopropyl cyclohexane-1,3-dione and -1,3,5-trione units to be incorporated into potent HPPD inhibitors. New routes involving original combinations of synthetic equivalents of α-cyclopropyl ketone-α-anion and α-cyclopropyl ester-β-cation are described. 相似文献
47.
Radical alkylation of 2-(tert-butyl)-2-methyldioxolan-4-one, a chiral equivalent of glycolic acid, occurs with good to high diastereoselectivity that compares favorably with the corresponding enolate alkylation. The importance of the position of the transition state position, early or late, is highlighted. 相似文献
48.
Hoffer L Renaud JP Horvath D 《Combinatorial chemistry & high throughput screening》2011,14(6):500-520
Fragment-based screening is an emerging technology which is used as an alternative to high-throughput screening (HTS), and often in parallel. Fragment screening focuses on very small compounds. Because of their small size and simplicity, fragments exhibit a low to medium binding affinity (mM to μM) and must therefore be screened at high concentration in order to detect binding events. Since some issues are associated with high-concentration screening in biochemical assays, biophysical methods are generally employed in fragment screening campaigns. Moreover, these techniques are very sensitive and some of them can give precise information about the binding mode of fragments, which facilitates the mandatory hit-to-lead optimization. One of the main advantages of fragment-based screening is that fragment hits generally exhibit a strong binding with respect to their size, and their subsequent optimization should lead to compounds with better pharmacokinetic properties compared to molecules evolved from HTS hits. In other words, fragments are interesting starting points for drug discovery projects. Besides, the chemical space of low-complexity compounds is very limited in comparison to that of drug-like molecules, and thus easier to explore with a screening library of limited size. Furthermore, the "combinatorial explosion" effect ensures that the resulting combinations of interlinked binding fragments may cover a significant part of "drug-like" chemical space. In parallel to experimental screening, virtual screening techniques, dedicated to fragments or wider compounds, are gaining momentum in order to further reduce the number of compounds to test. This article is a review of the latest news in both experimental and in silico virtual screening in the fragment-based discovery field. Given the specificity of this journal, special attention will be given to fragment library design. 相似文献
49.
A. Renaud 《Fresenius' Journal of Analytical Chemistry》1928,74(1-2):63-74
Ohne Zusammenfassung 相似文献
50.
Elizabeth Renaud Christian Robelin Aïmen E. Gheribi Patrice Chartrand 《The Journal of chemical thermodynamics》2011,43(8):1286-1298
A complete critical evaluation of all available phase diagram and thermodynamic data has been performed for all condensed phases of the (LiF + LiCl + NaF + NaCl + KF + KCl + MgF2 + MgCl2 + CaF2 + CaCl2 + SrF2 + SrCl2) system, and optimized model parameters have been found. The (LiCl + NaCl + KCl + MgCl2 + CaCl2 + SrCl2), (LiF + NaF + KF + MgF2 + CaF2 + SrF2), and (LiF + LiCl + NaF + NaCl + KF + KCl + MgF2 + MgCl2 + CaF2 + CaCl2) subsystems have been critically evaluated previously. The model parameters for the common-ion binary, common-anion ternary, and reciprocal ternary subsystems (i.e. systems with two cations and two anions) can be used to predict thermodynamic properties and phase equilibria for the multicomponent reciprocal system. The Modified Quasichemical Model in the Quadruplet Approximation was used for the molten salt phase. This model takes into account both first-nearest-neighbor (cation–anion) and second-nearest-neighbor (cation–cation and anion–anion) short-range ordering, and the coupling between them. Finally, the CaFCl–SrFCl solid solution was modeled using the Compound Energy Formalism. 相似文献